Transplanted Suprachiasmatic Nucleus Determines Circadian Period
Abstract
The pacemaker role of the suprachiasmatic nucleus in a mammalian circadian system was tested by neural transplantation by using a mutant strain of hamster that shows a short circadian period. Small neural grafts from the suprachiasmatic region restored circadian rhythms to arrhythmic animals whose own nucleus had been ablated. The restored rhythms always exhibited the period of the donor genotype regardless of the direction of the transplant or genotype of the host. The basic period of the overt circadian rhythm therefore is determined by cells of the suprachiasmatic region.
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In rodents, lesions of the suprachiasmatic nucleus abolish or attenuate daily rhythms in locomotor activity, body temperature, blood pressure, and heart rate, showing that these rhythms are endogenous rather than resulting from daily changes in behavior or environment.
“In rodents, lesions of the SCN abolish or attenuate daily rhythms in locomotor activity, body temperature, BP, and HR (22)(23)(24), showing that these rhythms are endogenous rather than resulting from daily changes in behavior or environment.”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [22]
Fetal SCN tissue transplanted into the hypothalamus of SCN-lesioned animals restores behavioral rhythms, and the circadian period of the recipient is determined by the donor animal rather than the host.
“Not only did these transplants restore behavioral rhythms, but the circadian period of the recipient also was determined by the period of the donor animal and not the previous period of the host (7).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [7]
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Ding, G., Gong, Y., Eckel-Mahan, K. L., & Sun, Z. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-13-1286-1_5 · Cited by 33 · see citing works
Changes in and dorsal to the rat suprachiasmatic nucleus during early pregnancy
Schrader, J. A., Nunez, A. A., & Smale, L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.057 · Cited by 26 · see citing works
Anatomy of the Mammalian Circadian System
Gooley, J. J., & Saper, C. B. (2017) · Principles and Practice of Sleep Medicine · doi:10.1016/b978-0-323-24288-2.00033-7 · Cited by 9 · see citing works
- Authors
- Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M.
- Affiliations
- University of Virginia (US)
- Department of Biology, University of Virginia, Charlottesville, VA 22903.
- Northeastern University (US)
- ORCID
- Ralph, Martin R.
- Venue
- Science
- Published
- 1990-02-23
- Volume
- 247
- Issue
- 4945
- Pages
- 975-978
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046577583
- Cited by
- 1,853
- References
- 24
- Citations by year
- 2026: 30 · 2025: 36 · 2024: 60 · 2023: 43 · 2022: 65 · 2021: 54 · 2020: 51 · 2019: 60 · 2018: 69 · 2017: 65 · 2016: 61 · 2015: 66 · 2014: 70 · 2013: 71 · 2012: 65
- FWCI
- 34.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32mh009483-03, 5r01hd013162-16)
- National Institute of Mental Health (MH09483)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 18686, HD-13162)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- suprachiasmatic nucleus, circadian period, circadian pacemaker, neural transplantation, neural grafts, circadian rhythm
- MeSH terms
- Animals, Circadian Rhythm, Cricetinae, Immunohistochemistry, Male, Mutation, Nerve Tissue, Neuropeptide Y, Suprachiasmatic Nucleus, Vasopressins
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