Ecdysterone induces acetylcholinesterase in mammalian brain
Abstract
The effects of ecdysterone on brain acetylcholinesterase (AChE) in immature and adult rats of both sexes have been studied in in vitro conditions. Ecdysterone produced an increase of AChE in rat brain slices. The most remarkable effect was found in immature male rats. In vitro assay using a purified AChE from electric eel showed no effect. Pretreatment with cycloheximide or actinomycin D abolished the ecdysterone action on brain AChE. These results support the idea that induction of AChE may be involved in the heterophilic action of ecdysterone.
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20HE could produce an increase in acetylcholinesterase in the rat brain, which could enhance learning capacity.
“Similarly, 20HE could produce an increase in acetylcholinesterase (AChE) in the rat brain [22], which could enhance learning capacity.”
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“[71] Effects of β -ecdysone on osteoblast viability by assessing apoptosis following treatment with excess glucocorticoids.”
BackgroundRoumanille, R., Vernus, B., Brioche, T., Descossy, V., Van Ba, C. T., Campredon, S., Philippe, A. G., Delobel, P., Bertrand-Gaday, C., Chopard, A., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00390-5 · Cited by 26 · see citing works
- Authors
- Catalan, R. E., Aragones, M. D., Godoy, J. E., & Martinez, A. M.
- Affiliations
- Universidad Autónoma de Madrid (ES)
- Venue
- Comparative Biochemistry and Physiology Part C: Comparative Pharmacology
- Publisher
- Elsevier BV
- Published
- 1984-01
- Volume
- 78
- Issue
- 1
- Pages
- 193-195
- ISSN
- 0306-4492 (ISSN-L)
- OpenAlex
- W2004648831
- Cited by
- 27
- References
- 18
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 4 · 2020: 3 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comparative Biochemistry and Physiology Part C Comparative Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 20-hydroxyecdysone, acetylcholinesterase, enzyme induction, brain, immature rats, cycloheximide, actinomycin D, ecdysteroid metabolism
- MeSH terms
- Acetylcholinesterase, Aging, Animals, Brain, Cycloheximide, Dactinomycin, Ecdysterone, Electrophorus, Enzyme Induction, Estradiol, Female, Male, Progesterone, Rats, Inbred Strains, Sex Characteristics, Testosterone, Rats
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