Alterations in Rat Lipid Metabolism Following Ecdysterone Treatment
Abstract
The influence of ecdysterone on the lipid metabolism in liver and adipose tissue from rat was investigated using 14C-acetate and 32P-orthophosphate as precursors. Ecdysterone produced an increase in 14C-acetate incorporation into triglycerides. A concomitant decrease in free fatty acids and diglycerides was observed. The effect of ecdysterone on triglyceride lipase activity was investigated and a significant decrease was found. Ecdysterone produced a significant increase in the specific activity of phosphatidylethanolamine and phosphatidylserine in liver. On the contrary, the specific activity of phosphatidylcholine was reduced. In adipose tissue, the most evident effect observed was the increase of specific activity of phosphatidylcholine. These results contribute to knowledge of the heterophylic action of ecdysterone.
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Ecdysterone does not appear to possess any severe side effects.
“Furthermore, ecdysterone does not appear to possess any severe side effects [19,47,49,50,51,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [75]
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- Authors
- Catalán, R. E., Martinez, A. M., Aragones, M. D., Miguel, B. G., Robles, A., & Godoy, J. E.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Catalán, R.E.
- ORCID
- Robles, A.
- Venue
- Comparative Biochemistry and Physiology Part B Comparative Biochemistry
- Publisher
- Elsevier BV
- Published
- 1985
- Volume
- 81
- Issue
- 3
- Pages
- 771-775
- ISSN
- 0305-0491 (ISSN-L)
- OpenAlex
- W2045291424
- Cited by
- 34
- References
- 16
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comparative Biochemistry and Physiology Part B Comparative Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- 20-hydroxyecdysone, lipid metabolism, liver, adipose tissue, triglyceride synthesis, triacylglycerol lipase, free fatty acids, diacylglycerol, phospholipids, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, insect hormones
- MeSH terms
- Acetates, Adipose Tissue, Animals, Carbon Radioisotopes, Diglycerides, Ecdysterone, Fatty Acids, Nonesterified, Liver, Male, Phosphates, Phospholipids, Phosphorus Radioisotopes, Protein Kinases, Rats, Inbred Strains, Triglycerides, Acetic Acid, Lipid Metabolism, Rats
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