The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.
Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
Abstract
The sensitivity of mitochondrial DNA to damage by mutagens predisposes mitochondria to injury on exposure of cells to genotoxins or oxidative stress. Damage to the mitochondrial genome causing mutations or loss of mitochondrial gene products, or to some nuclear genes encoding mitochondrial membrane proteins, may accelerate release of reactive species of oxygen. Such aberrant mitochondria may contribute to cellular aging and promotion of cancer.
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“As the integrity of mitochondrial DNA is essential for mitochondrial function, errors in gene expression may in result in dysfunctional mitochondrial subunits [15].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [15]
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Cited by
Sorted by citations
The Free Radical Theory of Aging Matures
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Oxidative damage and mitochondrial decay in aging.
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Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Harman, D. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90030-s · Cited by 902
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
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Metadata
- Authors
- Bandy, B., & Davison, A. J.
- Affiliations
- Simon Fraser University (CA)
- Corresponding author
- Bandy, Brian
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1990
- Volume
- 8
- Issue
- 6
- Pages
- 523-539
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2048339025
- Cited by
- 550
- References
- 218
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 2 · 2022: 12 · 2021: 5 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 19 · 2015: 17 · 2014: 26 · 2013: 22 · 2012: 20
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial DNA mutations, oxidative stress, carcinogenesis, cellular aging, reactive oxygen species, genotoxins, mitochondrial membrane proteins, mitochondrial dysfunction
- MeSH terms
- Aging, Animals, DNA, Mitochondrial, Humans, Mitochondria, Mutation, Neoplasms, Oxygen
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