The DOI matches its Crossref record; 85 of the 86 references it cites were found in a registry or an index.
Tolerance and safety of vitamin E: A toxicological position report
Abstract
From numerous publications on the "prophylactic" and "therapeutic" use of vitamin E, it may be concluded that the toxicity of vitamin E is very low. It has been demonstrated in animal experiments that vitamin E has neither mutagenic, teratogenic nor carcinogenic properties. Based on studies in humans, a daily dosage of 100-300 mg vitamin E can be considered harmless from a toxicological point of view. Using double-blind studies involving a large number of subjects, it has been demonstrated that large oral doses of up to 3,200 USP-Units/day led to no consistent adverse effects. From a large body of published data, dosage ranges have been deduced which can be characterized as safe for human subjects even where their use extends over a long period of time. It should, however, be noted that oral intake of high levels of vitamin E can exacerbate the blood coagulation defect of vitamin K deficiency caused by malabsorption or anticoagulant therapy. High levels of vitamin E intake are, therefore, contraindicated in these subjects.
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“Doses up to 400 mg can be considered absolutely safe, and vitamin E doses between 400 and 2000 mg also seem to cause no side effects [151,152].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [151]
In the citing paper
“Few side effects from vitamin E have been reported.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [151]
Citations
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Metadata
- Authors
- Kappus, H.
- Affiliations
- Freie Universität Berlin (DE)
- Corresponding author
- Kappus, H
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1992-07
- Volume
- 13
- Issue
- 1
- Pages
- 55-74
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1983748680
- Cited by
- 239
- References
- 86
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 3 · 2012: 8
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- vitamin E, alpha-tocopherol, toxicity, safety, mutagenicity, teratogenicity, carcinogenicity, high-dose vitamin E, coagulation, vitamin K deficiency, malabsorption, anticoagulation, tolerable daily intake
- MeSH terms
- Animals, Drug Tolerance, Free Radicals, Humans, Safety, Vitamin E
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