Cloning of human GAP 43: Growth association and ischemic resurgence

Ng, Shi-Chung; de la Monte, Suzanne M.; Conboy, Gary L.; Karns, Larry R.; Fishman, Mark C.

doi:10.1016/0896-6273(88)90197-3

Cited by 150Nerve injury and regenerationAxon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cloning of human GAP 43: Growth association and ischemic resurgence

Ng, Shi-Chung, de la Monte, Suzanne M., Conboy, Gary L., Karns, Larry R., Fishman, Mark C.·1988·Neuron

DOI 10.1016/0896-6273(88)90197-3

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Abstract

GAP-43 is a growth cone protein expressed in neurons especially during periods of axonal elongation. Poor repair in the adult mammalian CNS has been ascribed to restraints upon its expression. We have cloned human GAP-43 cDNA to investigate its potential involvement in neurological illness. Analysis of postmortem human brain tissue disclosed uniformly high expression of GAP-43 throughout the neonatal brain, whereas in the adult brain high levels of GAP-43 persist only in discrete regions. However, in the wake of ischemic injury in the adult brain, regions normally low in GAP-43 reexpress it at high levels, suggesting a role for GAP-43 in remodeling and repair of mature CNS neurons.

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After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates.
“After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates1–4,10,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [38]
PTEN inhibition potentiates axonal sprouting in optic nerve injury and spinal cord injury, through induction of PI3kinase signaling and activation of mTOR.
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From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [38]
Inhibition of SOCS3 further promotes axonal sprouting on top of PTEN inhibition.
“Inhibition of SOCS3 further promotes axonal sprouting on top of PTEN inhibition8,37,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [38]

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Authors: Ng, S.-C., de la Monte, S. M., Conboy, G. L., Karns, L. R., & Fishman, M. C.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Fishman, Mark C.
Venue: Neuron
Publisher: Elsevier BV
Published: 1988-04
Volume: 1
Issue: 2
Pages: 133-139
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/0896-6273(88)90197-3
OpenAlex: W2054092941
Cited by: 150
References: 41
Citations by year: 2025: 4 · 2024: 1 · 2022: 1 · 2021: 9 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 1
FWCI: 6.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: GAP-43, growth-associated protein, cDNA cloning, growth cones, axon elongation, CNS repair, ischemic injury, neuronal remodeling, postmortem brain, neonatal brain, neurological disorders
MeSH terms: Adolescent, Aging, Amino Acid Sequence, Base Sequence, Brain, Cerebral Infarction, DNA, Humans, Infant, Newborn, Membrane Glycoproteins, Middle Aged, Molecular Sequence Data, Nerve Tissue Proteins, GAP-43 Protein

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Cloning of human GAP 43: Growth association and ischemic resurgence

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