Cited by 339Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

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Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat

May, Patrick C., Lampert-Etchells, Martha, Johnson, Steven A., Poirier, Judes, Masters, Jeffrey N., Finch, Caleb E.·1990·Neuron

DOI 10.1016/0896-6273(90)90342-d

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Abstract

A hippocampal poly(A) RNA, pADHC-9, was cloned by differential screening of a human hippocampal cDNA library. By RNA blot analysis, pADHC-9 was elevated 2-fold in Alzheimer's disease hippocampus. In situ analyses identified pADHC-9 expression in pyramidal and non-pyramidal cells of the hippocampus and entorhinal cortex. Nucleotide sequence analysis identified pADHC-9 as a potential human homolog of rat sulfated glycoprotein 2 (SGP-2). SGP-2 expression increased in rat hippocampus following experimental lesions that mimic intrinsic neuronal loss and/or deafferentation. The function of pADHC-9 in brain has not been defined, but in serum, a similar protein inhibits complement-dependent cytolysis. Increased expression of pADHC-9 in Alzheimer's disease hippocampus may be a compensatory response mounted to retard a complement-driven neurodegenerative cascade.

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Authors: May, P. C., Lampert-Etchells, M., Johnson, S. A., Poirier, J., Masters, J. N., & Finch, C. E.
Affiliations: University of Southern California (US)
ORCID: May, Patrick C.
Poirier, Judes
Finch, Caleb E.
Venue: Neuron
Publisher: Elsevier BV
Published: 1990-12
Volume: 5
Issue: 6
Pages: 831-839
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/0896-6273(90)90342-d
OpenAlex: W2004102314
Cited by: 339
References: 30
Citations by year: 2026: 3 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 11 · 2013: 10 · 2012: 12
FWCI: 15.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 05142, P50AG005142)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, hippocampus, gene expression, sulfated glycoprotein-2, polyadenylated RNA, entorhinal cortex, experimental brain lesions, deafferentation, neuronal loss, complement-dependent cytotoxicity, neurodegeneration, compensatory response
MeSH terms: Alzheimer Disease, Autoradiography, Cloning, Molecular, Denervation, DNA, Glycoproteins, Hippocampus, Humans, Male, Nucleic Acid Hybridization, RNA, Transcription, Genetic, DNA Probes, Gene Expression, Molecular Chaperones, Clusterin

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Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat

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