The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat
Abstract
A hippocampal poly(A) RNA, pADHC-9, was cloned by differential screening of a human hippocampal cDNA library. By RNA blot analysis, pADHC-9 was elevated 2-fold in Alzheimer's disease hippocampus. In situ analyses identified pADHC-9 expression in pyramidal and non-pyramidal cells of the hippocampus and entorhinal cortex. Nucleotide sequence analysis identified pADHC-9 as a potential human homolog of rat sulfated glycoprotein 2 (SGP-2). SGP-2 expression increased in rat hippocampus following experimental lesions that mimic intrinsic neuronal loss and/or deafferentation. The function of pADHC-9 in brain has not been defined, but in serum, a similar protein inhibits complement-dependent cytolysis. Increased expression of pADHC-9 in Alzheimer's disease hippocampus may be a compensatory response mounted to retard a complement-driven neurodegenerative cascade.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“CLU was first associated with Alzheimer’s disease (AD) in 1990 when it was found to be increased in the hippocampi of AD patients (May, et al., 1990)”
From A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin (2016) · cites this paper as May, et al., 1990
Citations
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725
A simple and very efficient method for generating cDNA libraries
Gubler, U., & Hoffman, B. J. (1983) · Gene · doi:10.1016/0378-1119(83)90230-5 · Cited by 4,461
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells
Nadler, J. V., Perry, B. W., & Cotman, C. W. (1978) · Nature · doi:10.1038/271676a0 · Cited by 745
Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743
Perforant pathway changes and the memory impairment of Alzheimer's disease
Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., & Damasio, A. R. (1986) · Annals of Neurology · doi:10.1002/ana.410200406 · Cited by 672
Developmentally regulated expression of specific tau sequences
Kosik, K. S., Orecchio, L. D., Bakalis, S., & Neve, R. L. (1989) · Neuron · doi:10.1016/0896-6273(89)90077-9 · Cited by 598
Plasticity of Hippocampal Circuitry in Alzheimer's Disease
Geddes, J. W., Monaghan, D. T., Cotman, C. W., Lott, I. T., Kim, R. C., & Chui, H. C. (1985) · Science · doi:10.1126/science.4071042 · Cited by 461
Cited by
Sorted by citations
Items 301–339 of 339
Beiter, R. M., Raghavan, T. P., Suchocki, O., Ennerfelt, H. E., Rivet-Noor, C. R., Merchak, A. R., Phillips, J. L., Bathe, T., Lukens, J. R., Prokop, S., et al. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e41635 · Cited by 4
Subcellular proteomics insights into Alzheimer's disease development
Liang, Z., Zhuang, H., Cao, X., Ma, G., & Shen, L. (2023) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.202200112 · Cited by 3
The Radiogenomics of Late-onset Alzheimer Disease
Bonham, L. W., Sirkis, D. W., Hess, C. P., Sugrue, L. P., & Yokoyama, J. S. (2019) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0000000000000222 · Cited by 3
Jasmin, S. B. (2011) · eScholarship@McGill (McGill) · doi:10.82308/52384 · Cited by 3
Self-citationNaruse, I., Keino, H., TANIGUCHI, M., & Masaki, S. (1994) · Congenital Anomalies · doi:10.1111/j.1741-4520.1994.tb00801.x · Cited by 3
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular modelPreprint
Yuste‐Checa, P., Trinkaus, V. A., Riera-Tur, I., Imamoglu, R., Schaller, T., Wang, H., Dudanova, I., Hipp, M. S., Bracher, A., & Hartl, F. U. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.16.452659 · Cited by 4
Oligomeric amyloid beta prevents myelination in a clusterin-dependent mannerPreprint
Beiter, R. M., Raghavan, T. P., Suchocki, O., Ennerfelt, H. E., Rivet-Noor, C. R., Merchak, A. R., Phillips, J. L., Bathe, T., Lukens, J. R., Prokop, S., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4415143/v1 · Cited by 3
Rother, K. O., Till, G. O., & Hänsch, G. M. (1998) · Springer eBooks · doi:10.1007/978-3-642-58753-5_1 · Cited by 3
Structural signature of plasma proteins classifies the status of Alzheimer’s disease
Son, A., Kim, H., Diedrich, J. K., Bamberger, C., Wilkins, H., Burns, J. M., Morris, J. K., Rissman, R. A., Swerdlow, R. H., & Yates, J. R. (2026) · Nature Aging · doi:10.1038/s43587-026-01078-2 · Cited by 4
Cellular and molecular mechanisms of Alzheimer’s disease inflammation
Peery, H. E., Strohmeyer, R., & Rogers, J. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8350-4_1 · Cited by 2
Heterogeneity of Brain Gene Expression in Alzheimer's Diseasea
Duguid, J. R., TRZEPACZ, C., Kemper, T. L., Tourtellote, W., & Volicer, L. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb18297.x · Cited by 2
Neurotrophic factors and apoptosis in the nervous system
Batistatou, A. K., & Greene, L. A. (1993) · Elsevier eBooks · doi:10.1016/b978-0-444-81470-8.50009-0 · Cited by 2
Genetic Risk Factors: Their Function and Comorbidities in Alzheimer′s Disease
Hiltunen, M. O., Bertram, L., & Saunders, A. J. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/925362 · Cited by 1
Astrocyte/Oligodendrocyte Interaction in Association with Reactive Gliosis
Brosnan, C. F., Wu, E., Selmaj, K. W., & Raine, C. S. (1993) · Springer eBooks · doi:10.1007/978-1-4757-9486-1_34 · Cited by 1
Lord, J., & Morgan, K. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7309-1_3 · Cited by 1
Apolipoprotein E: Structural and Functional Interactions with Amyloid β
Stine, W. B., & LaDu, M. J. (2005) · Wiley eBooks · doi:10.1002/9783527619344.ch10 · Cited by 1
(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813102-2.05001-9 · Cited by 1
Study of Clusterin : an extracellular chaperone protein
Poon, S. (2002) · Research Online (University of Wollongong)
Simmons, C. R. (2011) · UKnowledge (University of Kentucky)
Role of the 39-kDa receptor-associated protein (RAP) in Alzheimer's disease
Hoang, T. (2012) · UTAS Research Repository · doi:10.25959/23206328
Tamashiro-Duran, J. H. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2011.tde-03012012-094605
Role and regulation of early complement activation products in Alzheimer’s disease
Veerhuis, R., Muiswinkel, F. L. V., Hack, C. E., & Eikelenboom, P. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8350-4_3
Flavonoids as regulators of amyloid precursor protein processing
Cox, C. J. (2014) · The University of Bath Online Publications Store (The University of Bath)
Russell, C., Liang, H., Hye, A., Chung, R., Bazenet, C. E., Lovestone, S., Pike, I., & Ward, M. A. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.455
P2‐030: INVESTIGATING THE ROLE OF CLU, PICALM, AND CR1 IN ALZHEIMER'S DISEASE
Lord, J., Turton, J. C., Braae, A., Barber, I., Medway, C., Brown, K. S., & Morgan, K. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.05.703
The Long Thread of GFAP in Aging, Steroids, and Synaptic Plasticity
Finch, C. E., Morgan, T. E., Rozovsky, I., & Wei, M. (2004) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-662-07019-2_13
Self-citationDevelopment‐ and activity‐dependent expression of clusterin in the mouse olfactory bulb
Wu, R., Xu, H., Rao, X., & Xu, F. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.06.009
Wang, E., Marcotte, R., Papaconstantinou, H. T., & Papaconstantinou, J. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)04032-9
Identification and Role of Non-Beta Components of Senile Plaque Amyloid in Alzheimer’s Disease
Takamaru, Y., Fukatsu, R., Tsuzuki, K., Chiba, H., Kobayashi, K., Nagasawa, S., Aizawa, Y., Fujii, N., Takahata, N., & Ueno, T. (1995) · Advances in behavioral biology · doi:10.1007/978-1-4757-9145-7_23
Pająk, B., Orzechowski, A., & Gajkowska, B. (2010) · Current Neurobiology
Hawley, B. (2012) · uO Research (University of Ottawa) · doi:10.20381/ruor-6225
SURFACE ENABLED LAB-ON-A-CHIP (LOC) DEVICE FOR PROTEIN DETECTION AND SEPARATION
Wang, Z. (2017) · Digital Commons - Michigan Tech (Michigan Technological University) · doi:10.37099/mtu.dc.etdr/472
(2007) · Elsevier eBooks · doi:10.1016/b978-012373657-4/50008-8
Expression and Purification of Mouse Sulfated Glycoprotein-2
Ji, Y., Lee, K. H., & You, K. (1995) · Molecules and Cells · doi:10.1016/s1016-8478(23)17344-4
Exploring the Mechanism of CLU Regulating Tau Pathology in the Pathogenesis of Alzheimer’s Disease
周, 杰. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1451464
Chen, F., Swartzlander, D. B., Ghosh, A., Fryer, J. D., Wang, B., & Zheng, H. (2021) · Figshare · doi:10.6084/m9.figshare.13671113
Mahmoudi, A.-E.-R. (2015) · theses.fr (ABES) · doi:10.70675/5f05520ez1713z4991za6c8z055ab117e2bb
Yang, Z., Sang, J., Lai, Y., Ding, X., Cao, S., Lei, C., Qi, T. A. N., He, L., Fan, L., & Zong, M. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117596
Cole (2000) · doi:10.1002/1097-0029(20000815)50:4
Metadata
- Authors
- May, P. C., Lampert-Etchells, M., Johnson, S. A., Poirier, J., Masters, J. N., & Finch, C. E.
- Affiliations
- University of Southern California (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 5
- Issue
- 6
- Pages
- 831-839
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2004102314
- Cited by
- 339
- References
- 30
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 11 · 2013: 10 · 2012: 12
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 05142, P50AG005142)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, hippocampus, gene expression, sulfated glycoprotein-2, polyadenylated RNA, entorhinal cortex, experimental brain lesions, deafferentation, neuronal loss, complement-dependent cytotoxicity, neurodegeneration, compensatory response
- MeSH terms
- Alzheimer Disease, Autoradiography, Cloning, Molecular, Denervation, DNA, Glycoproteins, Hippocampus, Humans, Male, Nucleic Acid Hybridization, RNA, Transcription, Genetic, DNA Probes, Gene Expression, Molecular Chaperones, Clusterin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
