Cited by 836Nerve injury and regenerationHereditary Neurological DisordersNuclear Receptors and Signaling

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

Berkemeier, Lucy R., Winslow, John W., Kaplan, David R., Nikolics, Karoly, Goeddel, David V., Rosenthal, Arnon·1991·Neuron

Abstract

In vertebrates, the formation and maintenance of neuronal connections are subject to regulation by multiple target-derived, diffusible (neurotrophic) factors. Here we describe the identification and characterization of a novel neurotrophic factor designated neurotrophin-5 (NT-5). NT-5 is structurally related to nerve growth factor and is expressed in embryonic as well as adult tissues. Recombinant NT-5 promotes the survival of peripheral sensory and sympathetic neurons and induces differentiation of the pheochromocytoma cell line PC12. NT-5 activates two trk-related tyrosine kinase receptors and shares these receptors with other neurotrophins. Activation of multiple receptors may permit a single neurotrophin to control target innervation by distinct neuronal populations. Receptor sharing could enable neurotrophic factors emanating from distinct targets to cooperate in regulating neurons with multiple connections.

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Crossref · 10.1016/0896-6273(91)90287-a

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  • NT-3 and NT-4 were identified by sequence similarity to NGF and BDNF.

    “The first neurotrophic factors, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were discovered through their ability to support the survival of neurons and neurites during development15–17; other members of the neurotrophin family, neurotrophin-3 (NT-3)18–20 and neurotrophin-4 (NT-4)21–23 were then identified through sequence similarity to NGF and BDNF.”

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Authors
Berkemeier, L. R., Winslow, J. W., Kaplan, D. R., Nikolics, K., Goeddel, D. V., & Rosenthal, A.
Affiliations
  • Genentech (US)
  • Frederick National Laboratory for Cancer Research (US)
Venue
Neuron
Publisher
Elsevier BV
Published
1991-11
Volume
7
Issue
5
Pages
857-866
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2080880626
Cited by
836
References
60
Citations by year
2026: 1 · 2025: 4 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 1 · 2018: 6 · 2017: 10 · 2016: 9 · 2015: 7 · 2014: 18 · 2013: 9 · 2012: 10
FWCI
36.07
Type
journal article
Language
en
Open access
closed
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01co074101-034)
  • National Cancer Institute (N01 CO-74101)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
neurotrophin-5, neurotrophic factors, Trk receptors, TrkB receptor, receptor tyrosine kinase, nerve growth factor, peripheral sensory neurons, sympathetic neurons, neuronal survival, neuronal innervation, target innervation
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, DNA, Gene Expression Regulation, Humans, Membrane Proteins, Molecular Sequence Data, Nerve Growth Factors, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Recombinant Proteins, Receptor, Ciliary Neurotrophic Factor, Receptor, trkA, Rats

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