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Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C
Abstract
In addition to serving as the precursor to a plethora of eicosanoids and other bioactive molecules, arachidonate may function as a bona fide second messenger. A number of studies have documented the ability of arachidonate to regulate the function of multiple targets in vitro systems. This has been particularly well established and studied with the activation of protein kinase C by arachidonate in a mechanism distinct from activation by diacylglycerol. In cells, arachidonate induces a number of activities, many of which may be independent of further metabolism to eicosanoids; suggesting possible direct action of arachidonate. This review summarizes the current state of knowledge on the possible second messenger function of arachidonate with specific emphasis on the regulation of protein kinase C.
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Metadata
- Authors
- Khan, W. A., Blobe, G. C., & Hannun, Y. A.
- Affiliations
- Duke Medical Center (US)
- Duke University (US)
- Corresponding author
- Khan, Wasiuddin A.
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 1995-03
- Volume
- 7
- Issue
- 3
- Pages
- 171-184
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2002668908
- Cited by
- 225
- References
- 105
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 2
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL43707, R01HL043707)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- arachidonic acid, free fatty acids, second messengers, protein kinase C, eicosanoids, fatty acid signaling
- MeSH terms
- Animals, Enzyme Activation, Fatty Acids, Nonesterified, Homeostasis, Humans, Models, Biological, Protein Kinase C, Second Messenger Systems, Eicosanoids, Arachidonic Acid
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