Cited by 225Protein Kinase Regulation and GTPase SignalingSphingolipid Metabolism and SignalingFatty Acid Research and Health

The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.

Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C

Khan, Wasiuddin A., Blobe, Gerard C., Hannun, Yusuf A.·1995·Cellular Signalling

DOI 10.1016/0898-6568(94)00089-t

Open this paper in CoChat — free account

Abstract

In addition to serving as the precursor to a plethora of eicosanoids and other bioactive molecules, arachidonate may function as a bona fide second messenger. A number of studies have documented the ability of arachidonate to regulate the function of multiple targets in vitro systems. This has been particularly well established and studied with the activation of protein kinase C by arachidonate in a mechanism distinct from activation by diacylglycerol. In cells, arachidonate induces a number of activities, many of which may be independent of further metabolism to eicosanoids; suggesting possible direct action of arachidonate. This review summarizes the current state of knowledge on the possible second messenger function of arachidonate with specific emphasis on the regulation of protein kinase C.

Integrity signals

Registry

Crossref · 10.1016/0898-6568(94)00089-t

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
Nishizuka, Y. (1992) · Science · doi:10.1126/science.1411571 · Cited by 4,472
cPLA2 is phosphorylated and activated by MAP kinase
Lin, L., Wartmann, M., Lin, A. Y., Knopf, J. L., Seth, A., & Davis, R. J. (1993) · Cell · doi:10.1016/0092-8674(93)90666-e · Cited by 1,851
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
Clark, J. D., Lin, L.-L., Kriz, R. W., Ramesha, C. S., Sultzman, L. A., Lin, A. Y., Milona, N., & Knopf, J. L. (1991) · Cell · doi:10.1016/0092-8674(91)90556-e · Cited by 1,688
Diversity of group types, regulation, and function of phospholipase A2.
Dennis, E. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36794-7 · Cited by 1,435
Biochemistry of Lipids, Lipoproteins and Membranes
(2021) · Elsevier eBooks · doi:10.1016/c2020-0-00089-7 · Cited by 1,402
Signaling through phosphatidylcholine breakdown.
Exton, J. H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40184-1 · Cited by 1,358
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.
Kishimoto, A., Takai, Y., Terutoshi, M. O. R. I., Kikkawa, U., & Nishizuka, Y. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85886-6 · Cited by 1,303
Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
Hannun, Y. A., & Bell, R. M. (1989) · Science · doi:10.1126/science.2643164 · Cited by 1,251
Self-citation
The sphingomyelin cycle and the second messenger function of ceramide.
Hannun, Y. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41834-5 · Cited by 1,229
Self-citation
How is the level of free arachidonic acid controlled in mammalian cells?
Irvine, R. F. (1982) · Biochemical Journal · doi:10.1042/bj2040003 · Cited by 1,187
Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36.
Abumrad, N. A., El‐Maghrabi, M. R., Amri, E., Lopez, E., & Grimaldi, P. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46753-6 · Cited by 1,028
Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain
House, C. M., & Kemp, B. E. (1987) · Science · doi:10.1126/science.3686012 · Cited by 989
Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.
Preiss, J., Loomis, C. R., Bishop, W. R., Stein, R. B., Niedel, J. E., & Bell, R. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84420-4 · Cited by 962
Protein kinase C - a question of specificity
Dekker, L. V., & Parker, P. J. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90038-8 · Cited by 934
The Metabolism of Phosphoinositide-Derived Messenger Molecules
Majerus, P. W., Connolly, T. M., Deckmyn, H., Ross, T. S., Bross, T. E., Ishii, H., Bansal, V. S., & Wilson, D. B. (1986) · Science · doi:10.1126/science.3024320 · Cited by 710
A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca 2+ -Dependent Protein Kinase
McPhail, L. C., Clayton, C. C., & D, R. S. M. (1984) · Science · doi:10.1126/science.6231726 · Cited by 614
Arachidonic Acid Cascade and Signal Transduction
Shimizu, T., & Wolfe, L. S. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08813.x · Cited by 591
Lipid activation of protein kinase C.
Bell, R. M., & Burns, D. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67698-2 · Cited by 555
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.
Hannun, Y. A., Loomis, C. R., & Bell, R. M. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39208-6 · Cited by 469
Self-citation
Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2
Sharp, J., White, D. L., Chiou, X. G., Goodson, T. G., III, Gamboa, G. C., McClure, D. B., Burgett, S. G., Hoskins, J., Skatrud, P. L., & Sportsman, J. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98550-9 · Cited by 448
Potentiation of NMDA receptor currents by arachidonic acid
Miller, B., Sarantis, M., Traynelis, S. F., & Attwell, D. (1992) · Nature · doi:10.1038/355722a0 · Cited by 425
The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells.
Kramer, R. M., Roberts, E. F., Manetta, J. V., & Putnam, J. E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67782-3 · Cited by 411
Biochemistry of Lipids, Lipoproteins and Membranes
Spector, A. A. (1992) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(92)90069-2 · Cited by 410
Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response
Crowl, R. M., Stoller, T. J., Conroy, R. R., & Stoner, C. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52293-6 · Cited by 409
Direct regulation of ion channels by fatty acids
Ordway, R. W., Singer, J. J., & Walsh, J. V. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90069-7 · Cited by 408
Structural and functional features of different types of cytoplasmic fatty acid-binding proteins
Veerkamp, J. H., Peeters, R. A., & Maatman, R. G. H. J. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90244-c · Cited by 387
Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.
Nalefski, E. A., Sultzman, L. A., Martin, D. M., Kriz, R., Towler, P., Knopf, J. L., & Clark, J. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32440-7 · Cited by 346
Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.
Jayadev, S., Linardic, C. M., & Hannun, Y. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37526-9 · Cited by 341
Self-citation
Differential regulation of rasGAP and neurofibromatosis gene product activities
Bollag, G. E., & McCormick, F. P. (1991) · Nature · doi:10.1038/351576a0 · Cited by 341
Metabolism of Glycerolipids
Lands, W. E. M., & Merkl, I. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81234-0 · Cited by 331
Potassium Channels in Cardiac Cells Activated by Arachidonic Acid and Phospholipids
Kim, D. H., & Clapham, D. E. (1989) · Science · doi:10.1126/science.2727703 · Cited by 331
Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate.
Prescott, S. M., & Majerus, P. W. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33114-4 · Cited by 315
Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.
Wolf, B. A., TURK, J. W., Sherman, W. R., & McDaniel, M. L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35676-4 · Cited by 311
Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids.
Murakami, K., Chan, S. Y., & Routtenberg, A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66728-6 · Cited by 305
Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium.
Gong, M. C., Fuglsang, A. T., Alessi, D. R., Kobayashi, S., Cohen, P., Somlyo, A. V., & Somlyo, A. P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36636-0 · Cited by 236
Protein kinase C contains two phorbol ester binding domains.
Burns, D. J., & Bell, R. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55274-1 · Cited by 235
Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acids
Sekiguchi, K., Tsukuda, M., Ogita, K., Kikkawa, U., & Nishizuka, Y. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91035-7 · Cited by 235
Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7
Leslie, C. C., Voelker, D. R., Channon, J. Y., Wall, M. M., & Zelarney, P. T. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90316-5 · Cited by 233
Fatty acid uptake by isolated rat heart myocytes represents a carrier-mediated transport process.
Stremmel, W. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113393 · Cited by 222
Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape change, serotonin release, and aggregation.
Siess, W., Siegel, F. L., & Lapetina, E. G. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44408-5 · Cited by 204
Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms.
Distel, R. J., Robinson, G. S., & Spiegelman, B. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42645-2 · Cited by 201
Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells.
Gronich, J. H., Bonventre, J. V., & Nemenoff, R. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37439-8 · Cited by 201
Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites
Shearman, M. S., Naor, Z., Sekiguchi, K., Kishimoto, A., & Nishizuka, Y. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80125-5 · Cited by 184
Group II phospholipase A2 mRNA synthesis is stimulated by two distinct mechanisms in rat vascular smooth muscle cells
Nakano, T., Ohara, O., Teraoka, H., & Arita, H. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80663-4 · Cited by 182
Requirement and role of arachidonic acid in the differentiation of pre-adipose cells
Gaillard, D., Négrel, R., Lagarde, M., & Ailhaud, G. P. (1989) · Biochemical Journal · doi:10.1042/bj2570389 · Cited by 179
Phospholipase D in cell signalling and its relationship to phospholipase C
Shukla, S. D., & Halenda, S. P. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90031-6 · Cited by 174
Apolipoprotein genetic variation and human disease
Breslow, J. L. (1988) · Physiological Reviews · doi:10.1152/physrev.1988.68.1.85 · Cited by 168
Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells.
Barbour, S. E., & Dennis, E. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80622-x · Cited by 154
Characterization of the phosphorylation sites in the chicken and bovine myristoylated alanine-rich C kinase substrate protein, a prominent cellular substrate for protein kinase C
Graff, J. M., Stumpo, D. J., & Blackshear, P. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80153-3 · Cited by 138
Stimulation of guanylate cyclase of fibroblasts by free fatty acids.
Wallach, D. P., & Pastan, I. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33126-5 · Cited by 133
At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.
Sorrentino, D. R., Robinson, R. B., Kiang, C. L., & Berk, P. D. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114301 · Cited by 133
Arachidonate release and phosphatidic acid turnover in stimulated human platelets.
Neufeld, E. J., & Majerus, P. W. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32948-x · Cited by 126
Bacterial lipopolysaccharide priming of P388D1 macrophage-like cells for enhanced arachidonic acid metabolism. Platelet-activating factor receptor activation and regulation of phospholipase A2.
Glaser, K. B., Asmis, R., & Dennis, E. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38938-0 · Cited by 121
Calcium-Independent Activation of Hypothalamic Type I Protein Kinase C by Unsaturated Fatty Acids
Naor, Z., Shearman, M. S., Kishimoto, A., & Nishizuka, Y. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-11-1043 · Cited by 118
Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition.
Touny, S. E., Khan, W., & Hannun, Y. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46241-7 · Cited by 114
Self-citation
Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate.
Khan, W. A., Blobe, G. C., & Hannun, Y. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50567-1 · Cited by 114
Self-citation
Purification and characterization of human platelet phospholipase A2 which preferentially hydrolyzes an arachidonoyl residue
Takayama, K., Kudo, I., Kim, D. K., Nagata, K., Nozawa, Y., & Inoue, K. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80506-x · Cited by 113
Cytoplasmic fatty acid binding protein: Significance for intracellular transport of fatty acids and putative role on signal transduction pathways
Glatz, J. F. C., Vork, M. M., Cistola, D. P., & Vusse, G. J. (1993) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(93)90007-j · Cited by 113
Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase
Irvine, R. F., Letcher, A., & DAWSON, R. M. C. (1979) · Biochemical Journal · doi:10.1042/bj1780497 · Cited by 110
Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.
Bishop, W. R., & Bell, R. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67117-0 · Cited by 107
Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.
Khan, W. A., Blobe, G. C., Halpern, A. E., Taylor, W., Wetsel, W. C., Burns, D., Loomis, C. R., & Hannun, Y. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53502-x · Cited by 106
Self-citation
Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex
Du, X., Harris, S. J., Tetaz, T., Ginsberg, M. H., & Berndt, M. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32301-3 · Cited by 106
Inhibition Studies on the Membrane-associated Phospholipase A2 in vitro and Prostaglandin E2 Production in vivo of the Macrophage-like P388D1 Cell
Lister, M. D., Glaser, K. B., Ulevitch, R. J., & Dennis, E. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81822-1 · Cited by 105
Enhancement of long-term potentiation by cis-unsaturated fatty acid: relation to protein kinase C and phospholipase A2
Linden, D. J., Sheu, F.-S., Murakami, K., & Routtenberg, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-11-03783.1987 · Cited by 104
Arachidonic acid inhibits sodium currents and synaptic transmission in cultured striatal neurons.
Fraser, D. D., Hoehn, K., Weiss, S., & MacVicar, B. (1993) · Neuron · doi:10.1016/0896-6273(93)90075-3 · Cited by 103
Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils
Abramson, S. B., Leszczynska-Piziak, J., & Weissmann, G. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.1.231 · Cited by 102
The control of free arachidonic acid levels
Burgoyne, R. D., & Morgan, A. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90227-3 · Cited by 100
Is arachidonic acid a second messenger in signal transduction?
Naor, Z. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90135-f · Cited by 100
Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid.
Lister, M. D., Deems, R. A., Watanabe, Y., Ulevitch, R. J., & Dennis, E. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68527-8 · Cited by 89
Arachidonic acid and diacylglycerol act synergistically to activate protein kinase C in vitro and in vivo
Lester, D. S., Collin, C., Etcheberrigaray, R., & Alkon, D. L. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91745-x · Cited by 87
Role of Activation of Protein Kinaso C in the Stimulation of Colonic Epithelial Proliferation by Unsaturated Fatty Acids
Craven, P. A., & DeRubertis, F. R. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80014-3 · Cited by 86
Arachidonic acid and endothelin potentiate Ca2+ transients in rat cardiac myocytes via inhibition of distinct K+ channels.
Damron, D. S., Wagoner, D. R. V., Moravec, C. S., & Bond, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74254-9 · Cited by 84
Cytoplasmic lipid bodies of neutrophils: formation induced by cis-unsaturated fatty acids and mediated by protein kinase C.
Weller, P. F., Ryeom, S. W., Picard, S. T., Ackerman, S. J., & Dvořàk, A. M. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.1.137 · Cited by 84
Exogenous Arachidonic Acid Promotes Insulin Release From Intact or Permeabilized Rat Islets by Dual Mechanisms: Putative Activation of Ca2+ Mobilization and Protein Kinase C
Metz, S. A. (1988) · Diabetes · doi:10.2337/diab.37.11.1453 · Cited by 82
Marked acceleration of exogenous fatty acid incorporation into cellular triglycerides by fetuin.
Cayatte, A. J., Kumbla, L., & Subbiah, M. T. R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39445-1 · Cited by 77
Bradykinin Stimulates Arachidonic Acid Release Through the Sequential Actions of an sn‐1 Diacylglycerol Lipase and a Monoacylglycerol Lipase
Allen, A. C., Gammon, C. M., Ousley, A. H., McCarthy, K. D., & Morell, P. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09372.x · Cited by 70
Arachidonic acid is essential for IgG Fc receptor-mediated phagocytosis by human monocytes
Lennartz, M. R., & Brown, E. J. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.2.621 · Cited by 69
Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets
Khan, W. A., Blobe, G. C., Richards, A. L., & Hannun, Y. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36943-0 · Cited by 64
Self-citation
alpha-Fetoprotein-mediated transfer of arachidonic acid into cultured cloned cells derived from a rat rhabdomyosarcoma.
Uriel, J., Naval, J., & Laborda, J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61391-2 · Cited by 63
Direct effect of arachidonic acid on protein kinase C and LH-stimulated steroidogenesis in rat Leydig cells; evidence for tonic inhibitory control of steroidogenesis by protein kinase C
López-Ruiz, M. P., Choi, M. S. K., Rose, M. P., West, A. P., & COOKE, B. A. (1992) · Endocrinology · doi:10.1210/endo.130.3.1311229 · Cited by 63
Insulin receptor tyrosine kinase-catalyzed phosphorylation of 422(aP2) protein. Substrate activation by long-chain fatty acid.
Hresko, R. C., Hoffman, R. D., Flores-Riveros, J. R., & Lane, M. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45329-4 · Cited by 62
Arachidonic acid activates Ca2+ extrusion in macrophages.
Randriamampita, C., & Trautmann, A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44712-0 · Cited by 56
Isolation and partial characterization of plasma membrane fatty acid binding proteins from myocardium and adipose tissue and their relationship to analogous proteins in liver and gut
Potter, B. J., Stump, D. D., Schwieterman, W. D., Sorrentino, D. R., Jacobs, L., Kiang, C.-L., Rand, J. H., & Berk, P. D. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(87)80283-8 · Cited by 55
Synergistic activation by Ras and 14-3-3 protein of a mitogen-activated protein kinase kinase kinase named Ras-dependent extracellular signal-regulated kinase kinase stimulator.
Shimizu, K., Kuroda, S., Yamamori, B., Matsuda, S., Kaibuchi, K., Yamauchi, T., Isobe, T., Irie, K., Matsumoto, K., & Takai, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31594-6 · Cited by 53
Increase of bradykinin-stimulated arachidonic acid release in a ΔF508 cystic fibrosis epithelial cell line
Levistre, R., Lemnaouar, M., Rybkine, T., Bereziat, G., & Masliah, J. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(93)90026-w · Cited by 49
Coordinate actions of arachidonic acid and protein kinase C in gonadotropin-releasing hormone-stimulated secretion of luteinizing hormone
Chang, J. P., Graeter, J. S., & Catt, K. J. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90537-1 · Cited by 48
Signal transduction by tumor necrosis factor alpha is mediated through a guanine nucleotide-binding protein in osteoblast-like cell line, MC3T3-E1.
Yanaga, F., Abe, M., Koga, T., & Hirata, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42738-x · Cited by 45
Platelet-derived growth factor stimulates a biphasic mobilization of arachidonic acid in Swiss 3T3 cells. The role of phospholipase A2.
Domin, J., & Rozengurt, E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52961-6 · Cited by 44
Differential modulation of a sodium conductance in skeletal muscle by intracellular and extracellular fatty acids
Wieland, S. J., Fletcher, J. E., & Gong, Q. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.2.c308 · Cited by 44
Oleate stimulation of diacylglycerol formation from phosphatidylcholine through effects on phospholipase D and phosphatidate phosphohydrolase
Siddiqui, R. A., & Exton, J. H. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17460.x · Cited by 43
Signal transduction: crosstalk
Nishizuka, Y. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90001-p · Cited by 42
Free fatty acids as modulators of the steroid hormone message
Nunez, E. A. (1993) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(93)90011-k · Cited by 40
Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol
Seifert, R., Schächtele, C., & Schultz, G. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90433-5 · Cited by 38
INCORPORATION AND METABOLISM OF [ 14 C]‐ARACHIDONIC ACID IN GUINEA‐PIG LUNGS
Jose, P. J., & Seale, J. P. (1979) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1979.tb08697.x · Cited by 36
cis-Unsaturated fatty acids stimulate catecholamine secretion, tyrosine hydroxylase and protein kinase C in adrenal medullary cells
Koda, Y., Wada, A., Yanagihara, N., Uezono, Y., & Izumi, F. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90076-6 · Cited by 34
Signal Transduction in Collagen-Stimulated Rat Platelets Is Composed of Three Stages
Nakano, T., Terawaki, A., & Arita, H. (1987) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a121981 · Cited by 31
Arachidonic andcis‐unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C
Khan, W. A., Touny, S. E., & Hannun, Y. A. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80843-r · Cited by 30
Self-citation
Inhibition of phospholipase A2 by cis-unsaturated fatty acids: evidence for the binding of fatty acid to enzyme
Raghupathi, R., & Franson, R. C. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90292-4 · Cited by 27
The effects of fatty acids on phosphoinositide synthesis and myo-inositol accumulation in exocrine pancreas.
Chaudhry, A., Laychock, S. G., & Rubin, R. N. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45396-3 · Cited by 26
Mitosis in hepatocytes is generally associated with elevated levels of the target polypeptide of a liver carcinogen
Custer, P. P., & Sorof, S. (1985) · Differentiation · doi:10.1111/j.1432-0436.1985.tb00529.x · Cited by 25
Membrane fatty acids, lipid peroxidation and adenylate cyclase activity in cultured neural cells
Murphy, M. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91197-0 · Cited by 24
Purification and characterization of a soluble phospholipase A2 from guinea pig lung
Bennett, C. F., McCarte, A., & Crooke, S. T. (1990) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(90)90526-4 · Cited by 20
Inositol 1,4,5-trisphosphate- and arachidonic acid-induced calcium mobilization in T and B lymphocytes
Corado, J., Deist, F. L., Griscelli, C., & Fischer, A. (1990) · Cellular Immunology · doi:10.1016/0008-8749(90)90318-l · Cited by 17
Arachidonic acid, a growth signal in murine P815 mastocytoma cells.
Butcher, R. D., Wojcik, S. J., Lints, T., Wilson, T., Schofield, P. C., & Ralph, R. K. (1993) · PubMed · Cited by 16
Evidence that Arachidonic Acid Influences Hen Granulosa Cell Steroidogenesis and Plasminogen Activator Activity by a Protein Kinase C-Independent Mechanism1
Johnson, A. L., & Tilly, J. L. (1990) · Biology of Reproduction · doi:10.1095/biolreprod43.6.922 · Cited by 13

Research works printed but not linked: 26

Graber, 1994, J. Lipid Med., 9, 91
Ono, 1989, 86, 4868
Hannun, 1986, J. biol. Chem., 261, 7148
Shinomura, 1991, 88, 5149
Chen, 1992, J. biol. Chem., 282, 33
Berry, 1990, 87, 2294
Aihara, 1991, 88, 11062
Yoshida, 1992, 89, 6443
Abumrad, 1991, 88, 6008
Werner, 1991, Mol. Pharmac., 39, 547
Butcher, 1993, Cancer Res., 53, 3405
Laposata, 1982, 79, 7654
Clark, 1990, 87, 7708
Lin, 1992, 89, 6147
Burch, 1986, 83, 7201
Bell, 1979, 76, 3238
Stemmel, 1985, 82, 4
Stemmel, 1985, J. clin. Invest., 75, 1026
Custer, 1984, 81, 6738
Bassuk, 1987, 84, 7547
Wolf, 1986, J. biol. Chem., 261, 3501, 10.1016/S0021-9258(17)35676-4 · DOI
Hwang, 1990, 87, 5706
Piomelli, 1989, 86, 8550
Waldman, 1987, Pharmac. Rev., 39, 163
Speizer, 1991, Am. J. Physiol., 261, E109
Lopez-Ruiz, 1992, Endocrinology, 130, 1122

Sorted by citations

Glutamate uptake
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential
Desbois, A. P., & Smith, V. J. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2355-3 · Cited by 1,551
Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples
Han, X., & Gross, R. W. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20023 · Cited by 1,126
Regulation of protein kinase C
Newton, A. C. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80058-0 · Cited by 914
Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids.
Czock, D., Keller, F., Rasche, F. M., & H??ussler, U. (2005) · Clinical Pharmacokinetics · doi:10.2165/00003088-200544010-00003 · Cited by 886

See all 225

Authors: Khan, W. A., Blobe, G. C., & Hannun, Y. A.
Affiliations: Duke Medical Center (US)
Duke University (US)
Corresponding author: Khan, Wasiuddin A.
ORCID: Blobe, Gerard C.
Hannun, Yusuf A.
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 1995-03
Volume: 7
Issue: 3
Pages: 171-184
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/0898-6568(94)00089-t
OpenAlex: W2002668908
Cited by: 225
References: 105
Citations by year: 2025: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 2
FWCI: 7.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL43707, R01HL043707)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: arachidonic acid, free fatty acids, second messengers, protein kinase C, eicosanoids, fatty acid signaling
MeSH terms: Animals, Enzyme Activation, Fatty Acids, Nonesterified, Homeostasis, Humans, Models, Biological, Protein Kinase C, Second Messenger Systems, Eicosanoids, Arachidonic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks