Cited by 463Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsChromosomal and Genetic Variations

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In vivo loss of telomeric repeats with age in humans

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Lindsey, Janet, McGill, Niolette I., Lindsey, Leon A., Green, Daryll K., Cooke, Howard J.·1991·Mutation Research/DNAging

DOI 10.1016/0921-8734(91)90032-7

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Abstract

Telomeric DNA in the skin cells of 21 human subjects aged between 0 and 92 years was quantified by determining the length of the telomeric smear and the relative amount of TTAGGG repeat sequences. Both telomere length and quantity of telomeric repeat sequences were found to decrease significantly with age. Telomere loss has previously been postulated to be a caused of cell senescence.

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Authors: Lindsey, J., McGill, N. I., Lindsey, L. A., Green, D. K., & Cooke, H. J.
Affiliations: Western General Hospital (GB)
Bangour Village Hospital (GB)
Corresponding author: Cooke, Howard J.
ORCID: Lindsey, Janet
Cooke, Howard J.
Venue: Mutation Research/DNAging
Publisher: Elsevier BV
Published: 1991-01
Volume: 256
Issue: 1
Pages: 45-48
ISSN: 0921-8734 (ISSN-L)
DOI: 10.1016/0921-8734(91)90032-7
OpenAlex: W1992520556
Cited by: 463
References: 12
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 16 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 13
FWCI: 3.99
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mutation Research/DNAging (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: telomere length, telomeric repeats, aging, skin cells, TTAGGG repeats, cellular senescence, telomere loss
MeSH terms: Epidermal Cells, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Child, Child, Preschool, Chromosomes, Humans, Infant, Infant, Newborn, Middle Aged, Repetitive Sequences, Nucleic Acid, Blotting, Southern, Telomere

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In vivo loss of telomeric repeats with age in humans

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