Wavelength dependence for UV-induced pyrimidine dimer formation in DNA of human peripheral blood lymphocytes
Abstract
An action spectrum for the induction of pyrimidine dimers in human peripheral lymphocytes was determined between 254 and 405 nm. The presence of pyrimidine dimers was determined as UV-induced lesions that were sensitive to the dimer-specific endonuclease from Micrococcus luteus in conjunction with agarose gel electrophoresis. The rate of induction of pyrimidine dimers was maximal at 254 nm. These values can be compared with action spectra for UV-induced in vitro responses of lymphocytes.
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UVA radiation has been shown since the 1970s to induce CPDs in bacteria, mammalian cells and human skin.
“In fact, UVA radiation has been shown since the 1970s, first in bacteria (29) and then in mammalian cells (32,55,(80)(81)(82)(83)(84) and human skin (61,65,(85)(86)(87), to be also able to induce CPDs.”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [82]
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Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup>
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- Authors
- Freeman, S. E., & Ryan, S. L.
- Affiliations
- Lovelace Medical Center (US)
- Corresponding author
- Freeman, Steven E.
- Venue
- Mutation Research/DNA Repair
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 235
- Issue
- 3
- Pages
- 181-186
- ISSN
- 0921-8777 (ISSN-L)
- OpenAlex
- W2070771103
- Cited by
- 19
- References
- 24
- Citations by year
- 2018: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mutation Research/DNA Repair (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- pyrimidine dimers, ultraviolet radiation, action spectrum, wavelength dependence, human peripheral blood lymphocytes, DNA damage, UV-induced DNA lesions
- MeSH terms
- Cell Survival, DNA, Dose-Response Relationship, Radiation, Electrophoresis, Agar Gel, Humans, Lymphocytes, Mutation, Pyrimidine Dimers, Ultraviolet Rays
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