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The effect of donor age on the processing of UV-damaged DNA by cultured human cells: Reduced DNA repair capacity and increased DNA mutability
Open accessAbstract
Aging in humans carries an increased risk of skin cancer, a disorder linked to somatic mutations in sun damaged skin. DNA repair plays a major role in protection against sun damage. We found an age-related decline in post-UV DNA repair capacity (measured by the ability to repair a UV-treated plasmid (pCMVcat)) of-0.6% per year (p = 0.0001) in cultured primary skin fibroblasts from normal donors from the first to the tenth decade of life. There was a corresponding age-related increase in post-UV mutability (measured as mutations introduced into a transfected, UV-treated plasmid (pSP189)) of +0.6% per year (p = 0.001) in lymphoblastoid cell lines from normal donors of the same age range. This study indicates that aging in humans is associated with decreasing ability to process new UV-induced DNA damage and this age-related reduction in DNA repair capacity and increase in DNA mutability is reflected in cultured skin and blood cells.
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Parris, C. N., & Kraemer, K. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7260 · Cited by 58
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Cited by
DePinho, R. A. (2000) · Nature · doi:10.1038/35041694 · Cited by 951
The pathogenesis of melanoma induced by ultraviolet radiation
Gilchrest, B. A., Eller, M. S., Geller, A. C., & Yaar, M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401707 · Cited by 876
Basal cell carcinomas: attack of the hedgehog
Epstein, E. H. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2503 · Cited by 834
DNA Damage, DNA Repair, Aging, and Neurodegeneration
Maynard, S., Fang, E. F., Scheibye-Knudsen, M., Croteau, D. L., & Bohr, V. A. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025130 · Cited by 438
Sunlight and skin cancer: another link revealed
Kraemer, K. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.11 · Cited by 403
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Metadata
- Authors
- Moriwaki, S.-I., Ray, S., Tarone, R. E., Kraemer, K. H., & Grossman, L.
- Venue
- Mutation Research/DNA Repair
- Publisher
- Elsevier BV
- Published
- 1996-10
- Volume
- 364
- Issue
- 2
- Pages
- 117-123
- ISSN
- 0921-8777 (ISSN-L)
- OpenAlex
- W2044938194
- Cited by
- 194
- References
- 1
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Moriwaki, S.-I., Ray, S., Tarone, R. E., Kraemer, K. H., & Grossman, L. (1996). The effect of donor age on the processing of UV-damaged DNA by cultured human cells: Reduced DNA repair capacity and increased DNA mutability. Mutation Research/DNA Repair. https://doi.org/10.1016/0921-8777(96)00029-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
