The DOI matches its Crossref record; 172 of the 172 references it cites were found in a registry or an index.
DNA Damage, DNA Repair, Aging, and Neurodegeneration
Open accessAbstract
Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids. The sequence of the human genome represents our genetic blueprint, and accumulating evidence suggests that loss of genomic maintenance may causally contribute to aging. Distinct evidence for a role of imperfect DNA repair in aging is that several premature aging syndromes have underlying genetic DNA repair defects. Accumulation of DNA damage may be particularly prevalent in the central nervous system owing to the low DNA repair capacity in postmitotic brain tissue. It is generally believed that the cumulative effects of the deleterious changes that occur in aging, mostly after the reproductive phase, contribute to species-specific rates of aging. In addition to nuclear DNA damage contributions to aging, there is also abundant evidence for a causative link between mitochondrial DNA damage and the major phenotypes associated with aging. Understanding the mechanistic basis for the association of DNA damage and DNA repair with aging and age-related diseases, such as neurodegeneration, would give insight into contravening age-related diseases and promoting a healthy life span.
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Cites
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Cited by
Ageing as a risk factor for neurodegenerative disease
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Self-citationCross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program
Geirsdottir, L., David, E., Keren-Shaul, H., Weiner, A., Bohlen, S. C., Neuber, J., Balic, A., Giladi, A., Sheban, F., Dutertre, C.-A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.010 · Cited by 461
Nuclear DNA damage signalling to mitochondria in ageing
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Metadata
- Authors
- Maynard, S., Fang, E. F., Scheibye-Knudsen, M., Croteau, D. L., & Bohr, V. A.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-09-18
- Volume
- 5
- Issue
- 10
- Pages
- a025130
- ISSN
- 2157-1422 (ISSN-L)
- OpenAlex
- W2173698021
- Cited by
- 438
- References
- 172
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Maynard, S., Fang, E. F., Scheibye-Knudsen, M., Croteau, D. L., & Bohr, V. A. (2015). DNA Damage, DNA Repair, Aging, and Neurodegeneration. Cold Spring Harbor Perspectives in Medicine. https://doi.org/10.1101/cshperspect.a025130
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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