Distribution and developmental change of vasopressin V1A and V2 receptor mRNA in rats
Abstract
With the reverse transcription-polymerase chain reaction (RT-PCR) method, we examined the tissue distribution of vasopressin V1A and V2 receptor transcripts in newborn and adult rats. In adult rats, vasopressin V1A receptor mRNA was detected in the brain, lung, liver and kidney, whereas vasopressin V2 receptor mRNA was found only in the kidney. In newborn rats, vasopressin V1A receptor mRNA was detected in the brain, liver, heart and kidney, whereas vasopressin V2 receptor mRNA in the kidney and brain. In the newborn rat brain the level of vasopressin V2 receptor mRNA decreased with age, and could not be detected in rats older than 2 weeks. Our results first demonstrated the extrarenal expression of vasopressin V2 receptor in the newborn rat brain. Also, the study showed that expressions of vasopressin V1A and V2 receptor mRNA transcripts are dynamically altered in the process of development.
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- Authors
- Hirasawa, A., Hashimoto, K., & Tsujimoto, G.
- Affiliations
- University of Yamanashi (JP)
- Corresponding author
- Tsujimoto, Gozoh
- Venue
- European Journal of Pharmacology Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 267
- Issue
- 1
- Pages
- 71-75
- ISSN
- 0922-4106 (ISSN-L)
- OpenAlex
- W2051433145
- Cited by
- 78
- References
- 18
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 6 · 2017: 2 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 1
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology Molecular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- vasopressin V1a receptor, V2 receptor, receptor mRNA expression, tissue distribution, developmental changes, neonatal rats, brain, kidney, age-related gene expression
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Base Sequence, Female, Male, Molecular Sequence Data, RNA, Messenger, Polymerase Chain Reaction, Rats, Sprague-Dawley, Receptors, Vasopressin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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