Distribution and developmental changes in vasopressin V2 receptor mRNA in rat brain
Abstract
The extrarenal presence of vasopressin V2 receptors (V2Rs) has been suggested but never been demonstrated. We investigated the distribution of V2R mRNA expression in the brain of newborn and adult rats using the reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization (ISH). RT-PCR assay revealed V2R mRNA in the cerebellum of both newborn and adult rats, and in the cerebrum of newborn but not adult rats. Further examination of the newborn rat brain by ISH showed dense localization of that V2R mRNA in the choroid plexus, and the neurons of the hippocampus and granular layer of the cerebellum. Epithelial cells and vascular endothelial cells were strongly stained in the choroid plexus. Moreover, expression of V2R mRNA in the hippocampus of the newborn rat decreased with age and could not be detected in rats more than 2 weeks old, while in the cerebellum V2R mRNA expression was stable and did not change with development. The results of our study have demonstrated the presence and distribution of V2R in the brain for the first time, and also show that expression of V2R mRNA in the hippocampus changes dynamically during the process of development. V2R may play an important role in the development of the central nervous system.
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- Authors
- Kato, Y., Igarashi, N., Hirasawa, A., Tsujimoto, G., & Kobayashi, M.
- Affiliations
- Tokyo Women's Medical University (JP)
- Corresponding author
- Kato, Youichiro
- ORCID
- Hirasawa, Akira
- Venue
- Differentiation
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 59
- Issue
- 3
- Pages
- 163-169
- ISSN
- 0301-4681 (ISSN-L)
- OpenAlex
- W2151611920
- Cited by
- 82
- References
- 21
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2019: 3 · 2018: 7 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 8 · 2013: 6 · 2012: 4
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Differentiation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- V2 receptor, brain development, cerebellum, hippocampus, choroid plexus, neonatal rat brain, age-related gene expression, central nervous system development
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Base Sequence, Brain, Molecular Sequence Data, RNA, Messenger, Polymerase Chain Reaction, Rats, Wistar, In Situ Hybridization, Receptors, Vasopressin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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