Distribution of messenger RNA for the vasopressin V1a receptor in the CNS of male and female rats
Abstract
The distribution of cells expressing mRNA encoding a vasopressin V1a receptor (V1aR) was examined in Long-Evans male and female rats by in situ hybridization using a [35S]cRNA probe. Specific hybridization to the vasopressin V1aR mRNA was evident in cells of the frontal cortex, piriform cortex, internal granular layer and the medial, dorsal, ventral and lateral portion of the anterior olfactory nucleus, zona limitans of the islands of Calleja, suprachiasmatic nucleus, CA1, CA2, CA3 and dentate gyrus of the hippocampus, paraventricular hypothalamic nucleus, ventromedial hypothalamic nucleus, arcuate nucleus, lateral habenular nucleus, and the molecular and granular cell layers of the cerebellum. The cerebellum, olfactory nucleus and the dentate gyrus appeared to be the most intensely labeled areas, while all other areas exhibited a lower level of expression. The anatomical distribution and the amount (as measured by optical density) of V1aR mRNA labeling was identical between male and female rats. This indicates that unlike the vasopressin gene itself, the expression of the vasopressin V1aR mRNA does not exhibit sexual dimorphism. These data demonstrate a wide spread distribution in the expression of the vasopressin V1aR mRNA in the CNS of male and female rats. This information on the anatomical distribution of the V1aR mRNA when combined with data concerning the anatomical distribution of the V1a binding sites, provides new information on the possible pre- and post-synaptic location of these neuropeptide receptors.
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The dose of 500 nM OT was selected after a pilot study using a range of doses from 50 nM to 1 μM, the largest dose reported.
“The dose of 500 nM was selected after a pilot study using a range of doses from 50nM to 1µM, the largest dose reported59.”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [59]
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- Authors
- Szot, P., Bale, T. L., & Dorsa, D. M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Szot, Patricia
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 24
- Issue
- 1-4
- Pages
- 1-10
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W2022227059
- Cited by
- 125
- References
- 2
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 5
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- U.S. Public Health Service (20311)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- vasopressin V1a receptor, mRNA distribution, central nervous system, sexual dimorphism, receptor expression, anterior olfactory nucleus, cerebellum, hippocampus, hypothalamic nuclei, paraventricular nucleus, arcuate nucleus, lateral habenula, suprachiasmatic nucleus, neuropeptide receptors, postsynaptic receptors, Long-Evans rats
- MeSH terms
- Animals, Autoradiography, Brain, Female, Male, Organ Specificity, RNA, Messenger, Sex Characteristics, Sex Factors, Sulfur Radioisotopes, Oligonucleotide Probes, In Situ Hybridization, Receptors, Vasopressin, Rats
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