Mechanism of action of androgen in hair follicles
Abstract
In order to investigate the mode of action of testosterone (T) on human hair follicles we studied the metabolism of T and localization of androgen receptors in outer root sheath cells (ORSC) and dermal papilla cells (DPC) from different body sites. T was principally metabolized to androstenedione (delta 4) even in beard ORSC as well as epidermal keratinocytes (EK), and the ratio of apparent 5 alpha-reductase (5 alpha-R) to 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) did not differ between these two kinds of cells. The 5 alpha-R activity in beard DPC was 3 times as high as that in occipital scalp and axillary DPC. The 5 alpha-R of beard DPC exhibited a narrow optimum pH of 5.5, which is characteristic of type 2 enzyme present in androgen target cells. In contrast, 5 alpha-R of DPC from axillary and occipital scalp hair showed a broad optimum pH range between 6.5-9.0 corresponding to type 1 5 alpha-R. Androgen receptors were detected in the DPC of beard and axillary hair follicles, but not in those of occipital scalp hair follicles using immunohistochemical staining with polyclonal anti-androgen receptor antibody. Epithelial cells of the hair bulb were not stained by the antibody. Androgen receptors were also detected in the nuclei of cultured beard and axillary DPC, but the DPC from occipital scalp hair follicles showed little staining with the antibody. We also examined the effects of T on the DNA synthesis and proliferation of cultured ORSC and DPC. T did not have a proliferative effect on either type of cell when cultured alone.(ABSTRACT TRUNCATED AT 250 WORDS)
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dermal papilla cells from occipital scalp do not express androgen receptor.
“while DPCs from the occipital scalp did not express AR [191]”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [191]
Cites
Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male Pseudohermaphroditism
Imperato-McGinley, J., Guerrero, L., Gautier, T., & Peterson, R. E. (1974) · Science · doi:10.1126/science.186.4170.1213 · Cited by 1,258 · see citing works
Induction of hair growth by implantation of cultured dermal papilla cells
Jahoda, C. A. B., Horne, K. A., & OLIVER, R. F. (1984) · Nature · doi:10.1038/311560a0 · Cited by 646 · see citing works
Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
Andersson, S., Berman, D. M., Jenkins, E. P., & Russell, D. W. (1991) · Nature · doi:10.1038/354159a0 · Cited by 643 · see citing works
Male hormone stimulation is prerequisite and an incitant in common baldness
Hamilton, J. B. (1942) · American Journal of Anatomy · doi:10.1002/aja.1000710306 · Cited by 469 · see citing works
Choudhry, R., Hodgins, M. B., van der Kwast, T., Brinkmann, A. O., & Boersma, W. J. A. (1992) · Journal of Endocrinology · doi:10.1677/joe.0.1330467 · Cited by 318 · see citing works
Andersson, S., Bishop, R. W., & Russell, D. W. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71614-1 · Cited by 248 · see citing works
The culture of dermal papilla cells from human hair follicles
Messenger, A. G. (1984) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1984.tb04705.x · Cited by 237 · see citing works
The experimental induction of whisker growth in the hooded rat by implantation of dermal papillae
OLIVER, R. F. (1967) · Development · doi:10.1242/dev.18.1.43 · Cited by 206 · see citing works
Regulation of Human Hair Growth by Steroid Hormones. I. Testosterone Metabolism in Isolated Hairs
Schweikert, H. U., & Wilson, J. D. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-5-811 · Cited by 202 · see citing works
Sexual differentiation: Basic and clinical aspects
(1984) · General and Comparative Endocrinology · doi:10.1016/0016-6480(84)90090-x · Cited by 194 · see citing works
Interaction between Prostatic Fibroblast and Epithelial Cells in Culture: Role of Androgen*
CHANG, S.-M., & Chung, L. W. K. (1989) · Endocrinology · doi:10.1210/endo-125-5-2719 · Cited by 174 · see citing works
Randall, V. A., Thornton, M. J., & Messenger, A. G. (1992) · Journal of Endocrinology · doi:10.1677/joe.0.1330141 · Cited by 133 · see citing works
The Transplantation of Individual Rat and Guinea-pig Whisker Papillae
Cohen, J. (1961) · Development · doi:10.1242/dev.9.1.117 · Cited by 127 · see citing works
Itami, S., Kurata, S., Sonoda, T., & Takayasu, S. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12514729 · Cited by 114 · see citing works
Self-citationThe in vitro properties of dermal papilla cell lines established from human hair follicles
Messenger, A. G., JENNIFER, H., & BLEEHEN, S. S. (1986) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1986.tb02846.x · Cited by 105 · see citing works
Syndromes of Androgen Resistance1
Wilson, J. D. (1992) · Biology of Reproduction · doi:10.1095/biolreprod46.2.168 · Cited by 90 · see citing works
Takayasu, S., & Adachi, K. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-6-1098 · Cited by 88 · see citing works
Self-citationItami, S., Kurata, S., & Takayasu, S. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12874003 · Cited by 85 · see citing works
Self-citationMechanism of Action of Androgen in Dermal Papilla Cells
Itami, S., Kurata, S., Sonoda, T., & Susumu, T. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb24403.x · Cited by 60 · see citing works
Self-citationMizokami, A., Saiga, H., Matsui, T., et al. (1992) · Endocrinologia Japonica · doi:10.1507/endocrj1954.39.235 · Cited by 54 · see citing works
Katsuoka, K., Schell, H., Hornstein, O. P., et al. (1986) · Archives of Dermatological Research · doi:10.1007/bf00404353 · Cited by 49 · see citing works
Induction of hair follicles in mouse skin by rat vibrissa dermal papillae
Pisansarakit, P., & Moore, G. P. M. (1986) · Development · doi:10.1242/dev.94.1.113 · Cited by 41 · see citing works
The syndromes of androgen resistance revisited
Pérez‐Palacios, G., Chávez, B. A., Méndez, J. P., et al. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90196-8 · Cited by 21 · see citing works
Orlowski, J., & CLARK, A. F. (1991) · Endocrinology · doi:10.1210/endo-128-2-872 · Cited by 19 · see citing works
Sonoda, T., Itami, S., Kurata, S., & Takayasu, S. (1993) · Journal of Dermatological Science · doi:10.1016/0923-1811(93)90041-m · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Cutaneous androgen metabolism: basic research and clinical perspectives
Chen, W., Thiboutot, D., & Zouboulis, C. C. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.00613.x · Cited by 273 · see citing works
Hormones and the pilosebaceous unit
Chen, W.-C., & Zouboulis, C. C. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.2.8354 · Cited by 110 · see citing works
Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells
Winiarska, A., Mandt, N., Kamp, H., Hossini, A., Seltmann, H., Zouboulis, C. C., & Blume-Peytavi, U. (2006) · Skin Pharmacology and Physiology · doi:10.1159/000095251 · Cited by 82 · see citing works
- Authors
- Itami, S., Sonoda, T., Kurata, S., & Takayasu, S.
- Corresponding author
- Itami, Satoshi
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 7
- Pages
- S98-S103
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2037040736
- Cited by
- 30
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2022: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Keywords
- androgen action, testosterone, hair follicle, dermal papilla cells, outer root sheath cells, androgen receptor, 5α-reductase, 17β-hydroxysteroid dehydrogenase, androstenedione, cyproterone acetate, cell proliferation, beard hair, axillary hair, body site differences
- MeSH terms
- Androstenedione, Cell Division, Cells, Cultured, DNA, Hair, Humans, Hydrogen-Ion Concentration, Immunohistochemistry, Male, Oxidoreductases, Receptors, Androgen, Testosterone, 17-Hydroxysteroid Dehydrogenases, Keratinocytes, Cyproterone Acetate, Cholestenone 5 alpha-Reductase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
