The DOI matches its Crossref record; 53 of the 57 references it cites were found in a registry or an index.
Effects of DNA methylation on DNA-binding proteins and gene expression
Abstract
DNA methyltransferase is needed for normal development, perhaps because DNA methylation plays a part in the control of gene activity. It is clear that the methylation of promoters often leads to repression of transcription. Studies of the mechanism suggest that repression may either result from the direct effects of methylation on transcription factors, or may be indirectly caused by repressor proteins that bind to methylated DNA. Current evidence suggests that both mechanisms can be involved.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is well known that DNA methylation can affect the binding of some TFs87.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [87]
Citations
Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Frommer, M., McDonald, L. E., Millar, D. S., Collis, C. M., Watt, F., Grigg, G. W., Molloy, P. L., & Paul, C. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1827 · Cited by 3,238
Lewis, J. D., Meehan, R. R., Henzel, W. J., Maurer-Fogy, I., Jeppesen, P., Klein, F., & Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90610-o · Cited by 1,371
Self-citationMonk, M., Boubelı́k, M., & Lehnert, S. A. (1987) · Development · doi:10.1242/dev.99.3.371 · Cited by 1,100
The essentials of DNA methylation
Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90526-i · Cited by 948
Self-citationCpG islands as gene markers in the human genome
Larsen, F., Gundersen, G., Lopez, R., & Prydz, H. (1992) · Genomics · doi:10.1016/0888-7543(92)90024-m · Cited by 922
DNA methylation and gene activity
Cedar, H. (1988) · Cell · doi:10.1016/0092-8674(88)90479-5 · Cited by 907
Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.Preprint
Kafri, T., Ariel, M. S., Brandeis, M., Shemer, R., Urven, L. E., McCarrey, J. R., Cedar, H., & Razin, A. (1992) · Genes & Development · doi:10.1101/gad.6.5.705 · Cited by 743
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Boyes, J., & Bird, A. P. (1991) · Cell · doi:10.1016/0092-8674(91)90267-3 · Cited by 733
Self-citationIdentification of a mammalian protein that binds specifically to DNA containing methylated CpGs
Meehan, R. R., Lewis, J., McKay, S. J., Kleiner, E., & Bird, A. P. (1989) · Cell · doi:10.1016/0092-8674(89)90430-3 · Cited by 677
Self-citation
Cited by
Sorted by citations
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Self-citationDas, P. M., & Singal, R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.07.151 · Cited by 1,469
MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin
Nan, X., Campoy, F. J., & Bird, A. P. (1997) · Cell · doi:10.1016/s0092-8674(00)81887-5 · Cited by 1,288
Self-citationIngelman‐Sundberg, M., Sim, S. C., Gomez, A. V., & Rodríguez‐Antona, C. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.004 · Cited by 1,180
DNA methylation in health and disease
Robertson, K. D., & Wolffe, A. P. (2000) · Nature Reviews Genetics · doi:10.1038/35049533 · Cited by 1,077
Metadata
- Authors
- Tate, P. H., & Bird, A. P.
- Affiliations
- University of Edinburgh (GB)
- ORCID
- Bird, Adrian P.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 1993
- Volume
- 3
- Issue
- 2
- Pages
- 226-231
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W1984004239
- Cited by
- 737
- References
- 57
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 29 · 2021: 21 · 2020: 34 · 2019: 22 · 2018: 21 · 2017: 20 · 2016: 31 · 2015: 25 · 2014: 33 · 2013: 26 · 2012: 35
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- DNA methylation, DNA methyltransferases, DNA-binding proteins, gene expression regulation, transcriptional repression, promoter methylation, transcription factors, repressor protein, epigenetics, development (biology)
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cytosine, DNA, DNA (Cytosine-5-)-Methyltransferases, DNA-Binding Proteins, Gene Expression Regulation, Humans, Methylation, Models, Genetic, Molecular Sequence Data, Promoter Regions, Genetic, Protein Binding, Repressor Proteins, Transcription Factors, Transcription, Genetic, Consensus Sequence, 5-Methylcytosine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
