Regulation of basal ACTH secretion by corticosterone is mediated by both type I (MR) and type II (GR) receptors in rat brain
Abstract
The mechanisms involved in the physiology of the secretion of ACTH are reviewed. The secretion is regulated by the biological consequences of the occupancy of high affinity mineralocorticoid (MR) and lower affinity glucocorticoid receptors (GR) for corticosterone at specific sites of the rat brain. The regulation by this mechanism of basal secretion during the circadian rhythm, the effect of adrenalectomy and of corticosterone replacement is discussed. Experiments with RU486, a specific glucocorticoid antagonist, suggest that occupancy of both MR and GR is required for normal control of ACTH at the time of peak activity. The occupancy of the GR for a few hours per day apparently suffices to maintain steady levels of the products of GR-responsive genes throughout the body.
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MRs are mostly occupied when CORT levels are low, such as during the morning trough in rodents.
“and consequently, the MRs are mostly occupied when CORT levels are low, such as during the morning trough of CORT in rodents (Bradbury et al., 1991).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Bradbury et al., 1991
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- Authors
- Bradbury, M. J., Akana, S. F., Cascio, C. S., Levin, N., Jacobson, L., & Dallman, M. F.
- Affiliations
- University of California, San Francisco (US)
- Icahn School of Medicine at Mount Sinai (US)
- Stanford University (US)
- Corresponding author
- Bradbury, M.J.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1991
- Volume
- 40
- Issue
- 1-3
- Pages
- 133-142
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2045861226
- Cited by
- 96
- References
- 0
- Citations by year
- 2024: 2 · 2023: 3 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Institute of Diabetes and Digestive and Kidney Diseases (DK28172)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- ACTH secretion, corticosterone, mineralocorticoid receptor, glucocorticoid receptor, adrenalectomy, corticosterone replacement, circadian rhythm
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Animals, Brain, Circadian Rhythm, Corticosterone, Mineralocorticoids, Receptors, Glucocorticoid, Receptors, Steroid, Receptors, Mineralocorticoid, Rats
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