Cited by 416Stress Responses and CortisolTreatment of Major DepressionAdrenal Hormones and Disorders

Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression

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Barden, Nicholas·2004·Journal of Psychiatry and Neuroscience

Abstract

Major alterations of the hypothalamic-pituitary-adrenocortical (HPA) system that can be reversed by successful antidepressant therapy are often seen in depressed patients. Persuasive evidence points to the involvement of a dysfunctional glucocorticoid receptor (GR) system in these changes. Support for this also comes from studies of transgenic mice that express an antisense RNA, complementary to the GR mRNA, and have numerous neuroendocrine characteristics of human depression as well as altered behaviour. Many of these neuroendocrine and behavioural characteristics of the transgenic mice can be reversed by antidepressants. A possible explanation for this is that the antidepressant-induced increase in GRs renders the HPA axis more sensitive to glucocorticoid feedback. This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs.

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Crossref · 10.1139/jpn.0421

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Authors
Barden, N.
Affiliations
Centre hospitalier de l'Université Laval (CA)
Corresponding author
Barden, Nicholas
Venue
Journal of Psychiatry and Neuroscience
Published
2004-05
Volume
29
Issue
3
Pages
185-193
ISSN
  • 1180-4882 (ISSN-L)
  • 1488-2434
OpenAlex
W20284704
Cited by
416
References
99
Citations by year
2026: 7 · 2025: 11 · 2024: 16 · 2023: 10 · 2022: 20 · 2021: 18 · 2020: 27 · 2019: 21 · 2018: 25 · 2017: 12 · 2016: 22 · 2015: 17 · 2014: 23 · 2013: 20 · 2012: 19
FWCI
7.53
Type
journal article
Language
en
Open access
Locations
  • Journal of Psychiatry and Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hypothalamic-pituitary-adrenal axis, depression, glucocorticoid receptor, antidepressant action, HPA axis dysregulation, glucocorticoid feedback, neuroendocrine dysfunction, antidepressant drug development
MeSH terms
Antidepressive Agents, Major Depressive Disorder, Humans, Hypothalamo-Hypophyseal System, Hypothalamus, Pituitary-Adrenal System, RNA, Antisense, Mutation, Missense

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