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Cited by 109Olfactory and Sensory Function StudiesIon Channels and ReceptorsNasal Surgery and Airway Studies

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The vomeronasal (Jacobson's) organ in man: ultrastructure and frequency of occurence

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Moran, David T., Jafek, Bruce W., Rowley, J.Carter·1991·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/0960-0760(91)90251-y
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Abstract

These investigations address three major questions: (1) What is the frequency of occurrence of the vomeronasal (Jacobson's) organ (VNO) in man? (2) what is the ultrastructure of the human VNO? and (3) does the VNO contain sensory receptor cells? Macroscopic and microscopic intranasal clinical examinations of over 200 persons revealed paired bilateral vomeronasal pits on the anterior 1/3 of the nasal septum in all cases. Biopsies of the vomeronasal pits and surrounding tissues were examined by light and electron microscopy. These studies showed that the vomeronasal pit leads to a closed tube, 2-8 mm long, lined by a unique pseudostratified columnar epithelium unlike any other in the human body. The anterior end of the tube is lined by tall, columnar cells with a sparse population of short microvilli. The posterior end of the VNO is lined by an epithelium that contains three morphologically distinct cell types: (1) basal cells; (2) "dark cells--tall, slender cells with heterochromatic nuclei and electron-dense cytoplasm that often contain mucigen-like granules; and (3) "light" cells--large, clear cells, extending from the basement membrane to the organ's lumen. Each "light" cell has a round, euchromatic nucleus and a clear cytoplasm that often contains many Golgi stacks and membrane-limited vesicles filled with material of modest electron density. The cell apex is tipped by a few short microvilli. Whether these cells subserve any sensory function awaits further investigation.

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Figures

Fig. 1 "Macro" photograph of a biopsy specimen from a human nasal septum containing a vomeronasal pit (P) and surrounding nasal mucosa (M). 25 × .
Fig. 1 "Macro" photograph of a biopsy specimen from a human nasal septum containing a vomeronasal pit (P) and surrounding nasal mucosa (M). 25 × .CC-BY-NC-ND · From the PDF
Fig. 5 Light micrograph of a cross section through the posterior 1/3 of a different VNO from that of Figs 1–4. The lumen (LU) is lined by a pseudostratified columnar epithelium with three distinct cell types: ea ( () , () ,, (
Fig. 5 Light micrograph of a cross section through the posterior 1/3 of a different VNO from that of Figs 1–4. The lumen (LU) is lined by a pseudostratified columnar epithelium with three distinct cell types: ea ( () , () ,, (CC-BY-NC-ND · From the PDF
Fig. 6 TEM of the VNO epithelium shown in Fig. 5. The "dark" cells (D) have elliptical, heterochromatic nuclei. The cytoplasm in the apical domain of the cells contains mucigen-like granules (M). The "light" cells have round, euchromatic nuclei (N). Note the membrane-limited vesicles (V) with contents of moderate electron density in the supranuclear cytoplasm. Golgi stacks (G) are abundant. Several slender microvilli (arrow) extend from the cell surface into the lumen (LU) of the VNO. Small basal cells (B) sit atop the basement membrane (BM). 2100 × .
Fig. 6 TEM of the VNO epithelium shown in Fig. 5. The "dark" cells (D) have elliptical, heterochromatic nuclei. The cytoplasm in the apical domain of the cells contains mucigen-like granules (M). The "light" cells have round, euchromatic nuclei (N). Note the membrane-limited vesicles (V) with contents of moderate electron density in the supranuclear cytoplasm. Golgi stacks (G) are abundant. Several slender microvilli (arrow) extend from the cell surface into the lumen (LU) of the VNO. Small basal cells (B) sit atop the basement membrane (BM). 2100 × .CC-BY-NC-ND · From the PDF
Fig. 7 Higher-magnification TEM of "light" cells in the human VNO epithelium. Note the vesicles (V) near the Golgi stacks (G) above the round, euchromatic nuclei (N). 6500 × .
Fig. 7 Higher-magnification TEM of "light" cells in the human VNO epithelium. Note the vesicles (V) near the Golgi stacks (G) above the round, euchromatic nuclei (N). 6500 × .CC-BY-NC-ND · From the PDF

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Metadata

Authors
Moran, D. T., Jafek, B. W., & Rowley, J. C.
Affiliations
  • Hospital of the University of Pennsylvania (US)
  • University of Colorado Anschutz (US)
Corresponding author
Moran, David T.
ORCID
Moran, David T.
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
1991-10
Volume
39
Issue
4
Pages
545-552
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/0960-0760(91)90251-y
OpenAlex
W2039091321
Cited by
109
References
18
Citations by year
2025: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 1 · 2013: 1
FWCI
2.29
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2p01ns020486-04)
  • National Institute of Neurological Disorders and Stroke (2-PO1-NS20486)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
Keywords
vomeronasal organ, ultrastructure, vomeronasal epithelium, dark cells, light cells, frequency of occurrence, nasal septum, olfaction
MeSH terms
Adult, Chemoreceptor Cells, Female, Humans, Male, Microscopy, Electron, Microscopy, Electron, Scanning, Nasal Septum, Olfactory Pathways

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