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Cited by 118Olfactory and Sensory Function StudiesIon Channels and ReceptorsHypothalamic control of reproductive hormones

Ultrastructure of the human vomeronasal organ

Stensaas, Larry J., Lavker, Robert M., Monti-Bloch, L., Grosser, Bernard I., Berliner, David L.·1991·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/0960-0760(91)90252-z
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Abstract

Virtually all vertebrates have a vomeronasal system whose involvement in pheromone detection plays a crucial role in reproduction. In humans, the vomeronasal organ has been assumed to be vestigial or absent and without functional significance. In the present study involving over 400 subjects, vomeronasal pits were observed in all individuals except those with pathological conditions affecting the septum. Electron microscopy of the adult human vomeronasal organ indicates the presence of two potential receptor elements in the pseudostratified epithelial lining: microvillar cells, and unmyelinated, intraepithelial axons. In addition, unmyelinated axons are common in the lamina propria surrounding the organ. They appear to constitute the components essential for a functional chemosensory system, and may thus provide the basis for a pheromone detection system as in other animals.

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Crossref · 10.1016/0960-0760(91)90252-z

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31 of 31 references verified0 citation errors · 0 not checkable

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  • The epithelium lining the human VNO is unlike that of VNOs in other species and unlike that of olfactory or respiratory epithelium in humans.

    “The epithelium lining the human VNO is unlike that of VNOs in other species and unlike that of olfactory or respiratory epithelium in humans (Moran et al., 1991;Stensaas et al., 1991).”

    From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991

  • The human vomeronasal epithelium differs in appearance from both the sensory and non-sensory epithelia in the VNOs of other species and from nasal 'respiratory' epithelium.

    “The human vomeronasal epithelium differs in appearance from both the sensory and non-sensory epithelia in the VNOs of other species and from nasal 'respiratory' epithelium (Moran et al., 1991;Stensaas et al., 1991).”

    From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991

  • There are axons within the human VNO and Schwann cell-wrapped bundles of axons underlying it, so it is somewhat surprising that Trotier et al. did not find S100 expression close to the VNO.

    “There are axons within the human VNO and Schwann cell-wrapped bundles of axons underlying it (Stensaas et al., 1991;Jahnke and Merker, 2000), so it is somewhat surprising that Trotier et al. did not find S100 expression close to the VNO (Trotier et al., 2000).”

    From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991

  • Axons are observed in the epithelium, but not in continuity or in synaptic contact with epithelial cells.

    “Axons are observed in the epithelium (Stensaas et al., 1991), but not in continuity or in synaptic contact with epithelial cells.”

    From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991

  • Axon bundles are reported in the submucosa, but do not appear to arise from axon bundles penetrating the lamina propria in the same way as in vomeronasal epithelia of other species.

    “Axon bundles are reported in the submucosa (Stensaas et al., 1991), but do not appear to arise from axon bundles penetrating the lamina propria in the same way as in vomeronasal epithelia of other species.”

    From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991

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Authors
Stensaas, L. J., Lavker, R. M., Monti-Bloch, L., Grosser, B. I., & Berliner, D. L.
Affiliations
  • University of Utah (US)
  • University of Pennsylvania (US)
Corresponding author
Stensaas, Larry J.
ORCID
Lavker, Robert M.
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
1991-10
Volume
39
Issue
4
Pages
553-560
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/0960-0760(91)90252-z
OpenAlex
W2081035242
Cited by
118
References
31
Citations by year
2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 1 · 2013: 3
FWCI
2.38
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
vomeronasal organ, pheromone detection, lamina propria, pseudostratified epithelium, chemosensory system, human reproduction, ultrastructure
MeSH terms
Adult, Autopsy, Axons, Chemoreceptor Cells, Epithelium, Fetus, Humans, Microscopy, Microscopy, Electron, Nasal Septum, Olfactory Pathways

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