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Cited by 66Hormonal and reproductive studiesOvarian function and disordersSexual Differentiation and Disorders

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Steroidal and non-steroidal factors in plasma sex hormone binding globulin regulation

Toscano, V., Balducci, R., Bianchi, P., Guglielmi, R., Mangiantini, A., Sciarra, F.·1992·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/0960-0760(92)90081-s
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Abstract

Sex hormone binding globulin (SHBG) is a specific steroid-binding plasma glycoprotein regulated by several factors. Sex steroids are currently considered to be the main physiological regulators of this protein. SHBG levels, in fact, increase during estrogen treatment and decrease after androgen administration. It is well known, however, that in many physiological and pathological conditions SHBG concentrations cannot be explained only on the basis of steroidal control mechanisms. The regulation of SHBG levels is in fact more complex and other factors can also affect its plasma values. Between the steroidal factors our attention was focused on the role of androgens, of glandular and peripheral origin, in their capacity to lower SHBG plasma levels. We studied hyperandrogenic conditions in prepubertal (65 subjects with precocious adrenarche and 16 girls with prepubertal hypertrichosis, aged between 4 and 8 years) and in adult age (51 hirsute patients aged between 14-35 years and 51 acneic patients aged between 15-40 years). The effects of dexamethasone and ACTH administration on SHBG plasma levels were also evaluated. The results obtained showed that in adult hyperandrogenic patients SHBG levels, significantly lower than in controls, were not always inversely correlated with androgen levels, which, on the contrary, were higher than in controls. In patients with precocious adrenarche we found an inverse correlation only between SHBG, which was significantly lower than normal, and…

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Research works printed but not linked: 27

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Metadata

Authors
Toscano, V., Balducci, R., Bianchi, P., Guglielmi, R., Mangiantini, A., & Sciarra, F.
Affiliations
  • Sapienza University of Rome (IT)
  • University of Rome Tor Vergata (IT)
Corresponding author
Toscano, V.
ORCID
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
1992-10
Volume
43
Issue
5
Pages
431-437
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/0960-0760(92)90081-s
OpenAlex
W1982968971
Cited by
66
References
0
Citations by year
2025: 4 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
sex hormone-binding globulin, hyperandrogenism, androgens, insulin, polycystic ovary syndrome, obesity, hirsutism, acne, dexamethasone, ACTH, body mass index, bone age, energy balance
MeSH terms
Adolescent, Adult, Androgens, Energy Intake, Child, Child, Preschool, Female, Growth Substances, Humans, Sex Hormone-Binding Globulin

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