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Cited by 338Bone health and osteoporosis researchFatigue and fracture mechanicsBone fractures and treatments

Mechanical and morphological effects of strain rate on fatigue of compact bone

Schaffler, M.B., Radin, E.L., Burr, D.B.·1989·Bone
DOI 10.1016/8756-3282(89)90055-0
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Abstract

Compact bone specimens were cyclically loaded in uniaxial tension for one million cycles; loading was performed at either of two physiological strain rates (0.01 s-1 or 0.03 s-1) and a physiological strain range (0-1200 microstrain). Microdamage in loaded and nonloaded control specimens was then assessed histomorphometrically. Fatigue, evidence by stiffness loss, was observed at both strain rates and was significantly greater in specimens loaded at the high experimental strain rate than in specimens loaded at the low strain rate. Morphologically, this fatigue corresponded to increased numbers of microcracks in the bone. These data show that fatigue and resultant microdamage are realistic expectations of cyclic loading within the physiological strain range. The rate at which strains are developed influences the fatigue behavior of compact bone, suggesting that cyclic loading at high physiological strain rates, characteristic of vigorous activities, is more damaging to compact bone than loading at lower physiological strain rates.

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Crossref · 10.1016/8756-3282(89)90055-0

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  • Microcrack accumulation increases exponentially with age in cortical bone.

    “Microcrack accumulation increases exponentially with age in cortical bone and is significantly higher in the bones of women versus men (12, 13).”

    From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [13]

  • Microcrack accumulation is significantly higher in the bones of women versus men.

    “Microcrack accumulation increases exponentially with age in cortical bone and is significantly higher in the bones of women versus men (12, 13).”

    From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [13]

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Authors
Schaffler, M. B., Radin, E. L., & Burr, D. B.
Affiliations
West Virginia University (US)
Corresponding author
Schaffler, M.B.
ORCID
Venue
Bone
Publisher
Elsevier BV
Published
1989
Volume
10
Issue
3
Pages
207-214
ISSN
  • 1873-2763 (ISSN-L)
  • 8756-3282
DOI
10.1016/8756-3282(89)90055-0
OpenAlex
W1999084944
Cited by
338
References
32
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 11 · 2021: 6 · 2020: 13 · 2019: 15 · 2018: 11 · 2017: 6 · 2016: 13 · 2015: 13 · 2014: 10 · 2013: 13 · 2012: 11
FWCI
3.83
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Bone (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2r01am027127-05a1)
  • National Center for Research Resources (SO7-RRO-443-18)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Physical Sciences › Engineering › Mechanics of Materials › Fatigue and fracture mechanics
  • Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
Keywords
cortical bone, fatigue (material), strain rate, microcracks, microdamage, stiffness loss, cyclic loading, uniaxial tension, histomorphometry, bone mechanical properties
MeSH terms
Animals, Bone and Bones, Cattle, Male, Microscopy, Interference, Stress, Physiological, Stress, Mechanical, Tensile Strength

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