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Cited by 131Bone health and osteoporosis researchElasticity and Material ModelingBone fractures and treatments

Age-related differences in post-yield damage in human cortical bone. Experiment and model

Courtney, Amy C., Hayes, Wilson C., Gibson, Lorna J.·1996·Journal of Biomechanics
DOI 10.1016/0021-9290(96)84542-8
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Abstract

Very few quantitative comparisons between mechanical test behavior of cortical bone and microscopic evidence of damage have been reported. In this study, the hypothesis that age-related degradation of mechanical properties in human cortical bone is associated with increases in damage in the form of microcracks was investigated. The initial modulus and yield stress were 6% (not significant) and 10% (p = 0.05) lower, respectively, in specimens from elderly femora than in specimens from young adult femora. However, both groups showed a 34% decrease in modulus after being loaded to 1% strain. Microcracks were observed in cement lines and between lamellae and were parallel to the loading direction. There were 50% more cracks in longitudinal sections of tested specimens than in controls from elderly femora; however, there were no more cracks in tested specimens than in controls from young adult femora. In addition, there were twice as many cracks in controls and three times as many cracks in tested specimens from elderly femora than in those from young adult femora (p < 0.01). A microstructurally based model was developed which supported the mechanical test results and indicated that damage began to develop at about 1500 mu epsilon. The results suggest that older bone may have reduced mechanical properties due to the presence of more microcracks, and that older bone is more susceptible to developing microcracks at a given strain level. However, the mechanical test data indicate that specimens from young adult femora also sustained some king of damage as a result of mechanical loading, which requires further investigation.

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Crossref · 10.1016/0021-9290(96)84542-8

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  • Microcrack accumulation increases exponentially with age in cortical bone.

    “Microcrack accumulation increases exponentially with age in cortical bone and is significantly higher in the bones of women versus men (12, 13).”

    From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [12]

  • Microcrack accumulation is significantly higher in the bones of women versus men.

    “Microcrack accumulation increases exponentially with age in cortical bone and is significantly higher in the bones of women versus men (12, 13).”

    From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [12]

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Authors
Courtney, A. C., Hayes, W. C., & Gibson, L. J.
Affiliations
Harvard University (US)
Corresponding author
Courtney, Amy C.
ORCID
Venue
Journal of Biomechanics
Publisher
Elsevier BV
Published
1996-11
Volume
29
Issue
11
Pages
1463-1471
ISSN
0021-9290 (ISSN-L)
DOI
10.1016/0021-9290(96)84542-8
OpenAlex
W2125296797
Cited by
131
References
47
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 6
FWCI
2.93
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Biomechanics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
Keywords
cortical bone, aging, microcracks, femur, mechanical properties, yield stress, elastic modulus, bone degradation, bone microarchitecture
MeSH terms
Adult, Aged, Aging, Analysis of Variance, Bone and Bones, Elasticity, Femur, Humans, Models, Biological, Stress, Mechanical, In Vitro Techniques

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