Cited by 192Cholesterol and Lipid MetabolismLipid Membrane Structure and BehaviorSteroid Chemistry and Biochemistry

Scavenger receptor class BI and selective cholesteryl ester uptake: partners in the regulation of steroidogenesis

Azhar, Salman, Reaven, Eve·2002·Molecular and Cellular Endocrinology

Abstract

The steroidogenic tissues have a special requirement for cholesterol, which is used as a substrate for steroid hormone biosynthesis. In many species this cholesterol is obtained from plasma lipoproteins by a unique pathway in which circulating lipoproteins bind to the surface of the steroidogenic cells and contribute their cholesteryl esters to the cells by a 'selective' process in which the whole lipoprotein particle does not enter the cell. This review describes the lipoprotein selective cholesteryl ester uptake process and its specific partnership with the HDL receptor, scavenger receptor class BI (SR-BI). It describes the characteristics of the selective pathway, and the molecular properties, localization, regulation, anchoring sites and potential mechanisms of action of SR-BI in facilitating cholesteryl ester uptake by steroidogenic cells.

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Registry

Crossref · 10.1016/s0303-7207(02)00222-8

Cites

292 of 292 references verified0 citation errors · 0 not checkable

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Authors
Azhar, S., & Reaven, E.
Affiliations
VA Palo Alto Health Care System (US)
Corresponding author
Azhar, Salman
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2002-09
Volume
195
Issue
1-2
Pages
1-26
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2004805723
Cited by
192
References
293
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 20 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 3
FWCI
1.72
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL 33881)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-56339, P30DK056339)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Keywords
HDL receptor, cholesterol absorption, steroidogenesis, steroidogenic cells, serum lipoproteins
MeSH terms
Animals, Cholesterol Esters, Gene Expression Regulation, Humans, Membrane Proteins, Receptors, Immunologic, Steroids, Receptors, Lipoprotein, CD36 Antigens, Receptors, Scavenger, Scavenger Receptors, Class B

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