Scavenger receptor class BI and selective cholesteryl ester uptake: partners in the regulation of steroidogenesis
Abstract
The steroidogenic tissues have a special requirement for cholesterol, which is used as a substrate for steroid hormone biosynthesis. In many species this cholesterol is obtained from plasma lipoproteins by a unique pathway in which circulating lipoproteins bind to the surface of the steroidogenic cells and contribute their cholesteryl esters to the cells by a 'selective' process in which the whole lipoprotein particle does not enter the cell. This review describes the lipoprotein selective cholesteryl ester uptake process and its specific partnership with the HDL receptor, scavenger receptor class BI (SR-BI). It describes the characteristics of the selective pathway, and the molecular properties, localization, regulation, anchoring sites and potential mechanisms of action of SR-BI in facilitating cholesteryl ester uptake by steroidogenic cells.
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Plasma lipoproteins are widely accepted as the principal source of cholesterol used for steroid biosynthesis.
“All three primary steroidogenic organs, namely the adrenal cortex, gonads and placenta, can biosynthesize cholesterol de novo under the regulation of tropic hormones and plasma lipoproteins are widely accepted as the principal source of cholesterol used for steroid biosynthesis [[5], [6], [7], [8]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [6]
All three primary steroidogenic organs (adrenal cortex, gonads, placenta) can biosynthesize cholesterol de novo under regulation of tropic hormones.
“All three primary steroidogenic organs, namely the adrenal cortex, gonads and placenta, can biosynthesize cholesterol de novo under the regulation of tropic hormones and plasma lipoproteins are widely accepted as the principal source of cholesterol used for steroid biosynthesis [[5], [6], [7], [8]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [6]
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Self-citation
- Authors
- Azhar, S., & Reaven, E.
- Affiliations
- VA Palo Alto Health Care System (US)
- Corresponding author
- Azhar, Salman
- ORCID
- Azhar, Salman
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 195
- Issue
- 1-2
- Pages
- 1-26
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2004805723
- Cited by
- 192
- References
- 293
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 20 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 3
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 33881)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-56339, P30DK056339)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- HDL receptor, cholesterol absorption, steroidogenesis, steroidogenic cells, serum lipoproteins
- MeSH terms
- Animals, Cholesterol Esters, Gene Expression Regulation, Humans, Membrane Proteins, Receptors, Immunologic, Steroids, Receptors, Lipoprotein, CD36 Antigens, Receptors, Scavenger, Scavenger Receptors, Class B
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