Cited by 226Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

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Tauopathies.

Gábor Géza Kovács·2018·Handbook of Clinical Neurology

DOI 10.1016/b978-0-12-802395-2.00025-0

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Abstract

Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The spectrum of tau pathologies expands beyond the traditionally discussed disease forms like Pick disease, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. Emerging entities and pathologies include globular glial tauopathies, primary age-related tauopathy, which includes neurofibrillary tangle dementia, chronic traumatic encephalopathy (CTE), and aging-related tau astrogliopathy. Clinical symptoms include frontotemporal dementia, corticobasal syndrome, Richardson syndrome, parkinsonism, pure akinesia with gait freezing and, rarely, motor neuron symptoms or cerebellar ataxia. Some disorders show specific neuroimaging features, while examination of the cerebrospinal fluid awaits markers for in vivo stratification of cases. The possibility of cell-to-cell propagation is a novel aspect of the pathogenesis of tauopathies, which is partly reflected by the hierarchic involvement of anatomic regions. This concept might have relevance for the development of therapies. For cost-effective screening for tau pathologies in neuropathologic practice, examination of the hippocampus, amygdala, and basal ganglia is recommended. Uncommon morphologies or unusually extensive forms of tau pathologies should raise the suspicion of a genetic background. Ongoing multidisciplinary studies are needed to understand the whole spectrum and significanc…

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Authors: Kovács, G. G.
Affiliations: Medical University of Vienna (AT)
Corresponding author: Gábor Géza Kovács
ORCID: Gábor Géza Kovács
Venue: Handbook of Clinical Neurology
Publisher: Elsevier
Published: 2018
Volume: 145
Pages: 355-368
ISSN: 0072-9752 (ISSN-L)
DOI: 10.1016/b978-0-12-802395-2.00025-0
OpenAlex: W4247443907
Cited by: 225
References: 73
Citations by year: 2026: 14 · 2025: 19 · 2024: 41 · 2023: 38 · 2022: 35 · 2021: 36 · 2020: 20 · 2019: 15 · 2018: 6
FWCI: 36.00
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Handbook of clinical neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: tauopathy, tau protein, neurodegenerative diseases, Pick's disease, progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, globular glial tauopathy, primary age-related tauopathy, chronic traumatic encephalopathy, frontotemporal dementia, corticobasal syndrome, Richardson syndrome, cell-to-cell transmission, cerebrospinal fluid biomarkers, neuroimaging
MeSH terms: Animals, Brain, Humans, tau Proteins, Tauopathies

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