The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Circadian Rhythm and the Gut Microbiome
Abstract
Circadian rhythms are 24-h patterns regulating behavior, organs, and cells in living organisms. These rhythms align biological functions with regular and predictable environmental patterns to optimize function and health. Disruption of these rhythms can be detrimental resulting in metabolic syndrome, cancer, or cardiovascular disease, just to name a few. It is now becoming clear that the intestinal microbiome is also regulated by circadian rhythms via intrinsic circadian clocks as well as via the host organism. Microbiota rhythms are regulated by diet and time of feeding which can alter both microbial community structure and metabolic activity which can significantly impact host immune and metabolic function. In this review, we will cover how host circadian rhythms are generated and maintained, how host circadian rhythms can be disrupted, as well as the consequences of circadian rhythm disruption. We will further highlight the newly emerging literature indicating the importance of circadian rhythms of the intestinal microbiota.
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In the citing paper
“The molecular mechanisms of circadian clocks are similar across all species and are regulated by genetic enhancer/repressor elements, epigenetic modulation by methylation and acetylation, post-translation modification of regulatory proteins, and a variety of hormonal and signaling molecules [220,229,231].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [229]
In the citing paper
“Circadian clocks exist in all cells, including the microbiome, and function as autonomous transcriptional-translational genetic feedback loops [228,229].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [229]
In the citing paper
“regulated by diet and time of feeding rather than environmental 24-hour light-dark cycles (Voigt et al., 2016;Johnson et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Voigt et al., 2016
In the citing paper
“this may also be true of microbial enzymatic activity because gut microbiota community structure and metabolic activity also feature biologic rhythms”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Voigt et al., 2016
In the citing paper
“gut microbiota community structure and metabolic activity also feature biologic rhythms”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Voigt et al., 2016
Citations
Cites
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Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
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Central and Peripheral Circadian Clocks in Mammals
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Circadian integration of metabolism and energetics
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Cited by
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Pessemier, B. D., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021) · Microorganisms · doi:10.3390/microorganisms9020353 · Cited by 689
Sun, H., Wu, Z., Nie, X.-W., & Bian, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01568 · Cited by 558
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 563
Gut microbiome and type 2 diabetes: where we are and where to go?
Sharma, S., & Tripathi, P. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.003 · Cited by 446
Metadata
- Authors
- Voigt, R. M., Forsyth, C. B., Green, S. J., Engen, P. A., & Keshavarzian, A.
- Affiliations
- Rush University Medical Center (US)
- University of Illinois Chicago (US)
- Corresponding author
- Keshavarzian, A.
- Venue
- International Review of Neurobiology
- Publisher
- Elsevier
- Published
- 2016
- Volume
- 131
- Pages
- 193-205
- ISSN
- 0074-7742 (ISSN-L)
- OpenAlex
- W2512637358
- Cited by
- 274
- References
- 56
- Citations by year
- 2026: 30 · 2025: 34 · 2024: 30 · 2023: 35 · 2022: 37 · 2021: 40 · 2020: 31 · 2019: 15 · 2018: 16 · 2017: 6
- FWCI
- 28.32
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian rhythm, gut microbiota, circadian clock, circadian rhythm disruption, meal timing, diet, microbial community structure, host-microbe interactions, immune function, metabolism, metabolic syndrome
- MeSH terms
- Gastrointestinal Microbiome, Animals, Circadian Rhythm, Humans
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