Cited by 281Circadian rhythm and melatoninGut microbiota and healthDietary Effects on Health

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Circadian Rhythm and the Gut Microbiome

Voigt, R.M., Forsyth, C.B., Green, S.J., Engen, P.A., Keshavarzian, A.·2016·International Review of Neurobiology

DOI 10.1016/bs.irn.2016.07.002

Open this paper in CoChat — free account

Abstract

Circadian rhythms are 24-h patterns regulating behavior, organs, and cells in living organisms. These rhythms align biological functions with regular and predictable environmental patterns to optimize function and health. Disruption of these rhythms can be detrimental resulting in metabolic syndrome, cancer, or cardiovascular disease, just to name a few. It is now becoming clear that the intestinal microbiome is also regulated by circadian rhythms via intrinsic circadian clocks as well as via the host organism. Microbiota rhythms are regulated by diet and time of feeding which can alter both microbial community structure and metabolic activity which can significantly impact host immune and metabolic function. In this review, we will cover how host circadian rhythms are generated and maintained, how host circadian rhythms can be disrupted, as well as the consequences of circadian rhythm disruption. We will further highlight the newly emerging literature indicating the importance of circadian rhythms of the intestinal microbiota.

Integrity signals

Registry

Crossref · 10.1016/bs.irn.2016.07.002

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
Social Jetlag: Misalignment of Biological and Social Time
Wittmann, M., Dinich, J., Merrow, M., & Roenneberg, T. (2006) · Chronobiology International · doi:10.1080/07420520500545979 · Cited by 2,625
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449

Show all 56 references

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions
Pessemier, B. D., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021) · Microorganisms · doi:10.3390/microorganisms9020353 · Cited by 689
Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide
Sun, H., Wu, Z., Nie, X.-W., & Bian, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01568 · Cited by 558
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 563
Gut microbiome and type 2 diabetes: where we are and where to go?
Sharma, S., & Tripathi, P. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.003 · Cited by 446
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319
Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition
Deaver, J. A., Eum, S. Y., & Toborek, M. J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00737 · Cited by 218
The Drosophila model for microbiome research
Douglas, A. E. (2018) · Lab Animal · doi:10.1038/s41684-018-0065-0 · Cited by 198
When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis
Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 199
Circadian and sleep dysfunction in Alzheimer’s disease
Uddin, M. S., Tewari, D., Mamun, A. A., Kabir, M. T., Niaz, K., Wahed, M. I. I., Barreto, G. E., & Ashraf, G. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101046 · Cited by 183
Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study
Collado, M. C., Engen, P. A., Bandín, C., Cabrera‐Rubio, R., Voigt, R. M., Green, S. J., Naqib, A., Keshavarzian, A., Scheer, F. A. J. L., & Garaulet, M. (2018) · The FASEB Journal · doi:10.1096/fj.201700697rr · Cited by 168
Self-citation
The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis
Dedrick, S., Sundaresh, B., Huang, Q., Brady, C., Yoo, T., Cronin, C. T., Rudnicki, C., Flood, M., Momeni, B., Ludvigsson, J., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00078 · Cited by 170
Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors
Pearce, S., Coia, H. G., Karl, J. P., Pantoja-Feliciano, I. G., Zachos, N. C., & Racicot, K. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01584 · Cited by 167
Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
Zhou, L., Zhang, Z., Nice, E. C., Huang, C., Zhang, W., & Tang, Y. C. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01238-y · Cited by 163
Diet as a Therapeutic Option for Adult Inflammatory Bowel Disease
Kakodkar, S., & Mutlu, E. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.08.016 · Cited by 158
Diet in Parkinson’s Disease: Critical Role for the Microbiome
Jackson, A., Forsyth, C. B., Shaikh, M., Voigt, R. M., Engen, P. A., Ramirez, V., & Keshavarzian, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01245 · Cited by 145
Self-citation
Recent advances in modulation of cardiovascular diseases by the gut microbiota
Masenga, S. K., Hamooya, B., Hangoma, J., Hayumbu, V., Ertuglu, L. A., Ishimwe, J., Rahman, S., Saleem, M., Laffer, C. L., Elijovich, F., et al. (2022) · Journal of Human Hypertension · doi:10.1038/s41371-022-00698-6 · Cited by 121
Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs
Feng, W., Liu, J., Ao, H., Yue, S., & Peng, C. Y. (2020) · Theranostics · doi:10.7150/thno.47289 · Cited by 131
Chronobiology and Chronomedicine
Gonçalves, C. F., & Meng, Q. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781839167553 · Cited by 120
Diet, Sleep, and Mental Health: Insights from the UK Biobank Study
Hepsomali, P., & Groeger, J. A. (2021) · Nutrients · doi:10.3390/nu13082573 · Cited by 134
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
parker, J., O'Brien, C., Hawrelak, J., & Gersh, F. (2021) · doi:10.20944/preprints202112.0088.v1 · Cited by 113
Complex interactions of circadian rhythms, eating behaviors, and the gastrointestinal microbiota and their potential impact on health
Kaczmarek, J. L., Thompson, S. V., & Holscher, H. D. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux036 · Cited by 117
Circadian Rhythm and Alzheimer’s Disease
Homolak, J., Mudrovčić, M., Vukić, B., & Toljan, K. (2018) · Medical Sciences · doi:10.3390/medsci6030052 · Cited by 120
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
Parker, J., O’Brien, C., Hawrelak, J., & Gersh, F. L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031336 · Cited by 114
Circadian Features of Neutrophil Biology
Aroca-Crevillén, A., Adrover, J. M., & Hidalgo, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00576 · Cited by 109
Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis
Quesada‐Vázquez, S., Aragonès, G., Bas-Prior, J. M. D., & Escoté, X. (2020) · Cells · doi:10.3390/cells9010176 · Cited by 111
The gut microbiome in Parkinson's disease: A culprit or a bystander?
Keshavarzian, A., Engen, P. A., Bonvegna, S., & Cilia, R. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.01.004 · Cited by 108
Self-citation
The connection of circadian rhythm to inflammatory bowel disease
Gombert, M., Carrasco‐Luna, J., Arboledas, G. P., & Codoñer‐Franch, P. (2018) · Translational research · doi:10.1016/j.trsl.2018.12.001 · Cited by 89
Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Schurhoff, N. A., & Toborek, M. J. (2023) · Molecular Brain · doi:10.1186/s13041-023-00997-0 · Cited by 95
Phenolic compounds and biological rhythms: Who takes the lead?
Ávila‐Román, J., Soliz‐Rueda, J. R., Bravo, F. I., Aragonès, G., Suárez, M., Arola‐Arnal, A., Mulero, M., Salvadó, M. J., Arola, L., Torres‐Fuentes, C., et al. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.04.050 · Cited by 96
Chronotype, social jet lag, sleep debt and food timing in inflammatory bowel disease
Chakradeo, P. S., Keshavarzian, A., Singh, S., Dera, A. E., Esteban, J. P., Lee, A. A., Burgess, H. J., Fogg, L., & Swanson, G. R. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.08.002 · Cited by 84
Self-citation
Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: a comprehensive review
Zhang, X., Wang, S., Xu, H., Yi, H., Guan, J., & Yin, S. (2021) · European Respiratory Review · doi:10.1183/16000617.0220-2020 · Cited by 84
The circadian clock and diseases of the skin
Duan, J., Greenberg, E. N., Karri, S. S., & D, B. A. M. (2021) · FEBS Letters · doi:10.1002/1873-3468.14192 · Cited by 85
Sleep, circadian rhythm and gut microbiota: alterations in Alzheimer’s disease and their potential links in the pathogenesis
Li, Y., Shao, L., Mou, Y., Zhang, Y., & Ping, Y. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1957407 · Cited by 84
Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD
Jiang, X., Zheng, J., Zhang, S., Wang, B., Wu, C., & Guo, X. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00361 · Cited by 80
Probiotic bacteria and bile acid profile are modulated by prebiotic diet and associate with facilitated diurnal clock/sleep realignment after chronic disruption of rhythms
Thompson, R. S., Gaffney, M., Hopkins, S., Kelley, T., González, A., Bowers, S. J., Vitaterna, M. H., Turek, F. W., Foxx, C. L., Lowry, C. A., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.006 · Cited by 82
Resynchronized rhythmic oscillations of gut microbiota drive time-restricted feeding induced nonalcoholic steatohepatitis alleviation
Xia, J., Guo, W., Hu, M., Jin, X., Zhang, S., Liu, B., Qiu, H., Wang, K., Zhuge, A., Li, S., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221450 · Cited by 75
The Role of Gut Microbiome in Sleep Quality and Health: Dietary Strategies for Microbiota Support
Sejbuk, M., Siebieszuk, A., & Witkowska, A. M. (2024) · Nutrients · doi:10.3390/nu16142259 · Cited by 83
Sleep Apnea Morbidity
Farré, N., Farré, R., & Gozal, D. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.03.001 · Cited by 71
Feeding Rapidly Alters Microbiome Composition and Gene Transcription in the Clownfish Gut
Parris, D. J., Morgan, M. M., & Stewart, F. J. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02479-18 · Cited by 71
The relationship between host circadian rhythms and intestinal microbiota: A new cue to improve health by tea polyphenols
Song, D., Yang, C. S., Zhang, X., & Wang, Y. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1719473 · Cited by 70
Keto microbiota: A powerful contributor to host disease recovery
Cabrera-Mulero, A., Tinahones, A., Bandera-Merchán, B., Moreno‐Indias, I., Macías‐González, M., & Tinahones, F. J. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09518-8 · Cited by 70
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity
Aguilar‐López, B. A., Moreno‐Altamirano, M. M. B., Dockrell, H. M., Duchen, M. R., & Sánchez‐García, F. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00051 · Cited by 73
Metabolic implications of circadian disruption
Fatima, N., & Rana, S. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02381-6 · Cited by 74
Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies
Codoñer‐Franch, P., Gombert, M., Martínez-Raga, J., & Cénit, M. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087579 · Cited by 74
Circadian rhythms in the pathogenesis of gastrointestinal diseases
Codoñer‐Franch, P., & Gombert, M. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i38.4297 · Cited by 63
Sleep and Microbiome in Psychiatric Diseases
Wagner‐Skacel, J., Dalkner, N., Mörkl, S., Kreuzer, K., Farzi, A., Lackner, S., Painold, A., Reininghaus, E. Z., Butler, M., & Bengesser, S. (2020) · Nutrients · doi:10.3390/nu12082198 · Cited by 63
Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
Frausto, D. M., Forsyth, C. B., Keshavarzian, A., & Voigt, R. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.736814 · Cited by 61
Self-citation
Mood‐related central and peripheral clocks
Ketchesin, K. D., Becker‐Krail, D. D., & McClung, C. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14253 · Cited by 67
Goals in Nutrition Science 2020-2025
Bassaganya-Riera, J., Berry, E. M., Blaak, E. E., Burlingame, B., le Coutre, J., van Eden, W., El‐Sohemy, A., German, J. B., Knorr, D., Lacroix, C., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.606378 · Cited by 70
Factors Affecting Gut Microbiome in Daily Diet
Su, Q., & Liu, Q. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.644138 · Cited by 60
Human Gut Microbiota Plasticity throughout the Life Course
Thriene, K., & Michels, K. B. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20021463 · Cited by 65
The Gut Microbiota during a Behavioral Weight Loss Intervention
Stanislawski, M. A., Frank, D. N., Borengasser, S. J., Ostendorf, D. M., Ir, D., Jambal, P., Bing, K., Wayland, L. T., Siebert, J., Bessesen, D. H., et al. (2021) · Nutrients · doi:10.3390/nu13093248 · Cited by 62
Rhythms of behavior: are the times changin’?
Häfker, N. S., & Tessmar‐Raible, K. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.10.005 · Cited by 61
Intermittent fasting contributes to aligned circadian rhythms through interactions with the gut microbiome
Daas, M. C., & de Roos, N. M. (2021) · Beneficial Microbes · doi:10.3920/bm2020.0149 · Cited by 58
Interactions between Gut Microbiota, Host Circadian Rhythms, and Metabolic Diseases
Zhang, M., Zhou, C., Li, X., Li, H., Han, Q., Chen, Z., Tang, W., & Yin, J. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100416 · Cited by 58
Linking the oral microbiome and salivary cytokine abundance to circadian oscillations
Sarkar, A., Kuehl, M. N., Alman, A. C., & Burkhardt, B. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-81420-3 · Cited by 50
The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disorders
Naufel, M. F., Truzzi, G., Ferreira, C. M., & Coelho, F. M. S. (2023) · Arquivos de Neuro-Psiquiatria · doi:10.1055/s-0043-1767818 · Cited by 70
Diurnal Timing Dependent Alterations in Gut Microbial Composition Are Synchronously Linked to Salt-Sensitive Hypertension and Renal Damage
Chakraborty, S., Mandal, J., Cheng, X., Galla, S., Hindupur, A., Saha, P., Yeoh, B. S., Mell, B., Yeo, J., Vijay–Kumar, M., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14830 · Cited by 45
Circadian dysregulation induces alterations of visceral sensitivity and the gut microbiota in Light/Dark phase shift mice
Hu, L., Li, G., Shu, Y.-Y., Hou, X., Yang, L., & Jin, Y. T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.935919 · Cited by 48
The Microbiome in Health and Disease from the Perspective of Modern Medicine and Ayurveda
Wallace, R. K. (2020) · Medicina · doi:10.3390/medicina56090462 · Cited by 47
Melatonin in Early Nutrition: Long-Term Effects on Cardiovascular System
Gombert, M., & Codoñer‐Franch, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136809 · Cited by 43
Dietary fiber ameliorates sleep disturbance connected to the gut–brain axis
Tang, M., Song, X., Zhong, W., Xie, Y., Liu, Y., & Zhang, X. (2022) · Food & Function · doi:10.1039/d2fo01178f · Cited by 43
The Microbiome as a Circadian Coordinator of Metabolism
Alvarez, Y., Glotfelty, L., Blank, N., Dohnalová, L., & Thaiss, C. A. (2020) · Endocrinology · doi:10.1210/endocr/bqaa059 · Cited by 39
The beneficial effects of intermittent fasting: an update on mechanism, and the role of circadian rhythm and gut microbiota
Hu, D., Xie, Z., Ye, Y., Bahijri, S., & Chen, M. (2020) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn-20-317 · Cited by 45
Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer
Fellows, R. C., Chun, S. K., Larson, N., Fortin, B. M., Mahieu, A. L., Song, W. A., Seldin, M. M., Pannunzio, N. R., & Masri, S. (2024) · Science Advances · doi:10.1126/sciadv.ado1458 · Cited by 42
The Molecular Genetic Interaction Between Circadian Rhythms and Susceptibility to Seizures and Epilepsy
Re, C. J., Batterman, A. I., Gerstner, J. R., Buono, R. J., & Ferraro, T. N. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00520 · Cited by 38
Circadian dysrhythmia-linked diabetes mellitus: Examining melatonin’s roles in prophylaxis and management
Onaolapo, A. Y., & Onaolapo, O. J. (2018) · World Journal of Diabetes · doi:10.4239/wjd.v9.i7.99 · Cited by 43
Glucocorticoids coordinate changes in gut microbiome composition in wild North American red squirrels
Petrullo, L. A., Ren, T., Wu, M., Boonstra, R., Palme, R., Boutin, S. A., McAdam, A. G., & Dantzer, B. (2022) · Scientific Reports · doi:10.1038/s41598-022-06359-5 · Cited by 40
Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota
Pan, S., Guo, Y., Hong, F., Xu, P., & Zhai, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166281 · Cited by 37
Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Adeola, H. A., Papagerakis, S. M., & Papagerakis, P. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00399 · Cited by 40
The role of the intestinal microbiota in the pathogenesis of host depression and mechanism of TPs relieving depression
Liu, Y., Wu, Z., Cheng, L., Zhang, X., & Yang, H. (2021) · Food & Function · doi:10.1039/d1fo01091c · Cited by 37
Circadian disruption alters gut barrier integrity via a ß-catenin-MMP-related pathway
Eum, S. Y., Schurhoff, N. A., Téglás, T., Wolff, G., & Toborek, M. J. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04536-8 · Cited by 39
The Eye Sees Eye to Eye With the Immune System: The 2019 Proctor Lecture
Niederkorn, J. Y. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-28632 · Cited by 35
Modelling spatial patterns in host‐associated microbial communities
Ruuskanen, M. O., Sommeria‐Klein, G., Havulinna, A. S., Niiranen, T., & Lahti, L. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15462 · Cited by 33
Methionine Restriction Improves Gut Barrier Function by Reshaping Diurnal Rhythms of Inflammation-Related Microbes in Aged Mice
Ren, B., Wang, L., Mulati, A., Liu, Y., Liu, Z., & Liu, X. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.746592 · Cited by 34
Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders
Zimmermann, P., Kurth, S., Pugin, B., & Bokulich, N. A. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00605-6 · Cited by 38
The Gut Microbiome-Neuroglia Axis: Implications for Brain Health, Inflammation, and Disease
Camberos-Barraza, J., Guadrón‐Llanos, A. M., & la Herrán-Arita, A. K. D. (2024) · Neuroglia · doi:10.3390/neuroglia5030018 · Cited by 34
ω‐3 PUFAs Alleviate High‐Fat Diet–Induced Circadian Intestinal Microbes Dysbiosis
Gui, L., Chen, S., Wang, H., Ruan, M., Liu, Y., Li, N., Zhang, H., & Liu, Z. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900492 · Cited by 32
Therapeutic potential of melatonin as a chronobiotic and cytoprotective agent in diabetes mellitus
Wajid, F., Poolacherla, R., Mim, F. K., Bangash, A., & Rutkofsky, I. H. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00585-2 · Cited by 33
Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review
Lederer, A., Chikhladze, S., Kohnert, E., Huber, R., & Müller, A. (2021) · Diagnostics · doi:10.3390/diagnostics11112099 · Cited by 32
Ruminal Microbes Exhibit a Robust Circadian Rhythm and Are Sensitive to Melatonin
Ouyang, J., Wang, M., Bu, D., Ma, L., Liu, F., Chun, X., Du, C., Aboragah, A. A., & Loor, J. J. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.760578 · Cited by 28
Gut microbiota: Candidates for a novel strategy for ameliorating sleep disorders
Li, L., Liang, T., Jiang, T., Li, Y., Yang, L., Wu, L., Yang, J., Ding, Y., Wang, J., Chen, M., et al. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2228409 · Cited by 31
Sleep deprivation-induced anxiety-like behaviors are associated with alterations in the gut microbiota and metabolites
Zhang, N., Gao, X., Li, Y., Xu, L., Zhou, G., Xu, M., Peng, L., Sun, G., Pan, F., Li, Y., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01437-23 · Cited by 33
Chronic Inflammatory Diseases: Are We Ready for Microbiota-based Dietary Intervention?
Viennois, É., Gewirtz, A. T., & Chassaing, B. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.02.008 · Cited by 31
A Scoping Review of the Relationship between Intermittent Fasting and the Human Gut Microbiota: Current Knowledge and Future Directions
Popa, A. D., Niță, O., Gherasim, A., Enache, A. I., Caba, L., Mihalache, L., & Arhire, L. I. (2023) · Nutrients · doi:10.3390/nu15092095 · Cited by 31
Proof‐of‐principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota
Chellappa, S. L., Engen, P. A., Naqib, A. D., Qian, J., Vujovic, N., Rahman, N., Green, S. J., Garaulet, M., Keshavarzian, A., & Scheer, F. A. J. L. (2021) · The FASEB Journal · doi:10.1096/fj.202101153r · Cited by 28
Self-citation
Low circadian clock genes expression in cancers: A meta-analysis of its association with clinicopathological features and prognosis
Zhang, J., Lv, H., Ji, M., Wang, Z., & Wu, W. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233508 · Cited by 27
How longitudinal data can contribute to our understanding of host genetic effects on the gut microbiome
Grieneisen, L., Blekhman, R., & Archie, E. A. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2178797 · Cited by 29
The Role of Race, Sex, and Age in Circadian Disruption and Metabolic Disorders
Zhang, C., Tait, C., Minacapelli, C. D., Bhurwal, A., Gupta, K., Amin, R. N., & Rustgi, V. K. (2022) · Gastro Hep Advances · doi:10.1016/j.gastha.2022.02.015 · Cited by 27
Gut Microbiota in Diagnosis, Therapy and Prognosis of Cholangiocarcinoma and Gallbladder Carcinoma—A Scoping Review
Lederer, A., Rasel, H., Kohnert, E., Kreutz, C., Huber, R., Badr, M. T., Dellweg, P. K. E., Bartsch, F., & Lang, H. (2023) · Microorganisms · doi:10.3390/microorganisms11092363 · Cited by 26
The attenuation of gut microbiota-derived short-chain fatty acids elevates lipid transportation through suppression of the intestinal HDAC3-H3K27ac-PPAR-γ axis in gestational diabetes mellitus
Chen, H., Wang, S., Li, H., Zhou, X., Zhou, L.-W., Chen, C., Mansell, T., Novakovic, B., Saffery, R., Baker, P. N., et al. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109708 · Cited by 25
Variation in human gut microbiota impacts tamoxifen pharmacokinetics
Alam, Y. H., Hakopian, S., de Ora, L. O., Tamburini, I. J., Avelar‐Barragan, J., Jung, S., Long, Z. G., Chao, A., Whiteson, K., Jang, C., et al. (2024) · mBio · doi:10.1128/mbio.01679-24 · Cited by 24
Melatonin and inflammatory bowel disease: From basic mechanisms to clinical application
Vaghari‐Tabari, M., Moein, S., Alipourian, A., Qujeq, D., Malakoti, F., Alemi, F., Yousefi, B., & Khazaie, S. (2022) · Biochimie · doi:10.1016/j.biochi.2022.12.007 · Cited by 24
New hints for improving sleep: Tea polyphenols mediate gut microbiota to regulate circadian disturbances
Xiang, Q., Liu, Y., Wu, Z., Wang, R., & Zhang, X. (2023) · Food Frontiers · doi:10.1002/fft2.199 · Cited by 27
Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice
Guo, Y., Wei, J., Liu, C.-J., Li, X., & Yan, W. (2023) · eLife · doi:10.7554/elife.88310 · Cited by 25
Overview of the Gut–Brain Axis: From Gut to Brain and Back Again
Post, Z., Manfready, R. A., & Keshavarzian, A. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1771464 · Cited by 25
Self-citation
Circadian rhythm, microglia-mediated neuroinflammation, and Alzheimer’s disease
Geng, F., Zhao, N., & Ren, Q. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106044 · Cited by 22
Lactiplantibacillus plantarum 124 Modulates Sleep Deprivation-Associated Markers of Intestinal Barrier Dysfunction in Mice in Conjunction with the Regulation of Gut Microbiota
Li, L., Wu, L., Jiang, T., Liang, T., Yang, L., Li, Y., Gao, H., Zhang, J., Xie, X., & Wu, Q. (2023) · Nutrients · doi:10.3390/nu15184002 · Cited by 22
Role of the microbiota in circadian rhythms of the host
Schmalle, V., & Lorentz, A. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1726374 · Cited by 25

Authors: Voigt, R. M., Forsyth, C. B., Green, S. J., Engen, P. A., & Keshavarzian, A.
Affiliations: Rush University Medical Center (US)
University of Illinois Chicago (US)
Corresponding author: Keshavarzian, A.
ORCID: Voigt, R.M.
Forsyth, C.B.
Green, S.J.
Engen, P.A.
Keshavarzian, A.
Venue: International Review of Neurobiology
Publisher: Elsevier
Published: 2016
Volume: 131
Pages: 193-205
ISSN: 0074-7742 (ISSN-L)
DOI: 10.1016/bs.irn.2016.07.002
OpenAlex: W2512637358
Cited by: 274
References: 56
Citations by year: 2026: 30 · 2025: 34 · 2024: 30 · 2023: 35 · 2022: 37 · 2021: 40 · 2020: 31 · 2019: 15 · 2018: 16 · 2017: 6
FWCI: 28.32
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International review of neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords: circadian rhythm, gut microbiota, circadian clock, circadian rhythm disruption, meal timing, diet, microbial community structure, host-microbe interactions, immune function, metabolism, metabolic syndrome
MeSH terms: Gastrointestinal Microbiome, Animals, Circadian Rhythm, Humans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Circadian Rhythm and the Gut Microbiome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks