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Exercise and Parkinson's disease
Abstract
Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the world. Unfortunately, most of the currently used clinical therapies against PD are symptomatic and there is still no remedy can stop disease progression. Collective evidence shows that various kinds of exercise may reduce the risk of PD and do have positive impacts on both motor and nonmotor symptoms of PD. Additionally, exercise can also ameliorate the side effects such as wearing-off and dyskinesia induced by anti-PD therapeutics. In parallel with its benefits in ameliorating clinical symptoms, exercise modulates a range of supporting systems for brain maintenance and plasticity including neurogenesis, synaptogenesis, enhanced metabolism and angiogenesis. Exercise provides all these broad benefits on PD through inhibiting oxidative stress, repairing mitochondrial damage, and promoting the production of growth factors. Moreover, exercise reduces risk of other geriatric diseases such as diabetes, hypertension and cardiovascular disease, which may also contribute to PD pathogenesis. In summary, exercise is increasingly considered to be a complementary strategy to PD medications. In this chapter, we summarize the recent research progress on the beneficial effects of exercise on PD, discuss the underlying mechanisms, and highlight the promising prospects of exercise for antiparkinsonian therapy.
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“These beneficial changes underscore the importance of exercise in preventing and slowing the progression of ageing as well as neurodegenerative diseases.504–508”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [504]
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Metadata
- Authors
- Xu, X., Fu, Z., & Le, W.
- Affiliations
- Dalian Medical University (CN)
- Corresponding author
- Le, Weidong
- Venue
- International Review of Neurobiology
- Publisher
- Elsevier
- Published
- 2019
- Volume
- 147
- Pages
- 45-74
- ISSN
- 0074-7742 (ISSN-L)
- OpenAlex
- W2982404680
- Cited by
- 158
- References
- 71
- Citations by year
- 2026: 13 · 2025: 28 · 2024: 33 · 2023: 20 · 2022: 31 · 2021: 24 · 2020: 9
- FWCI
- 46.13
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, physical activity, neurodegeneration, motor symptoms, non-motor symptoms, wearing-off phenomenon, dyskinesia, antiparkinsonian drugs, neurogenesis, synaptogenesis, angiogenesis, oxidative stress, mitochondrial damage, growth factors, neuroplasticity, geriatric comorbidities, antiparkinsonian therapy
- MeSH terms
- Animals, Disease Models, Animal, Exercise Therapy, Humans, Parkinson Disease, Physical Conditioning, Animal, Exercise
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