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Cited by 158Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersNuclear Receptors and Signaling

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Exercise and Parkinson's disease

Xu, Xiaojiao, Fu, Zhenfa, Le, Weidong·2019·International Review of Neurobiology
DOI 10.1016/bs.irn.2019.06.003
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Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the world. Unfortunately, most of the currently used clinical therapies against PD are symptomatic and there is still no remedy can stop disease progression. Collective evidence shows that various kinds of exercise may reduce the risk of PD and do have positive impacts on both motor and nonmotor symptoms of PD. Additionally, exercise can also ameliorate the side effects such as wearing-off and dyskinesia induced by anti-PD therapeutics. In parallel with its benefits in ameliorating clinical symptoms, exercise modulates a range of supporting systems for brain maintenance and plasticity including neurogenesis, synaptogenesis, enhanced metabolism and angiogenesis. Exercise provides all these broad benefits on PD through inhibiting oxidative stress, repairing mitochondrial damage, and promoting the production of growth factors. Moreover, exercise reduces risk of other geriatric diseases such as diabetes, hypertension and cardiovascular disease, which may also contribute to PD pathogenesis. In summary, exercise is increasingly considered to be a complementary strategy to PD medications. In this chapter, we summarize the recent research progress on the beneficial effects of exercise on PD, discuss the underlying mechanisms, and highlight the promising prospects of exercise for antiparkinsonian therapy.

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Crossref · 10.1016/bs.irn.2019.06.003

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  1. WHO Guidelines Approved by the Guidelines Review Committee, 2010

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Metadata

Authors
Xu, X., Fu, Z., & Le, W.
Affiliations
Dalian Medical University (CN)
Corresponding author
Le, Weidong
ORCID
Venue
International Review of Neurobiology
Publisher
Elsevier
Published
2019
Volume
147
Pages
45-74
ISSN
0074-7742 (ISSN-L)
DOI
10.1016/bs.irn.2019.06.003
OpenAlex
W2982404680
Cited by
158
References
71
Citations by year
2026: 13 · 2025: 28 · 2024: 33 · 2023: 20 · 2022: 31 · 2021: 24 · 2020: 9
FWCI
46.13
Type
book chapter
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International review of neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords
Parkinson's disease, physical activity, neurodegeneration, motor symptoms, non-motor symptoms, wearing-off phenomenon, dyskinesia, antiparkinsonian drugs, neurogenesis, synaptogenesis, angiogenesis, oxidative stress, mitochondrial damage, growth factors, neuroplasticity, geriatric comorbidities, antiparkinsonian therapy
MeSH terms
Animals, Disease Models, Animal, Exercise Therapy, Humans, Parkinson Disease, Physical Conditioning, Animal, Exercise

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