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Cited by 462Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesHistone Deacetylase Inhibitors Research

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms

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Athar, Mohammad, Back, Jung Ho, Kopelovich, Levy, Bickers, David R., Kim, Arianna L.·2009·Archives of Biochemistry and Biophysics
DOI 10.1016/j.abb.2009.01.018PMC PMC2749321
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Abstract

Plant-derived polyphenolic compounds, such as the stilbene resveratrol (trans-3,4',5-trihydroxystilbene), have been identified as potent anti-cancer agents. Extensive in vitro studies revealed multiple intracellular targets of resveratrol, which affect cell growth, inflammation, apoptosis, angiogenesis, and invasion and metastasis. These include tumor suppressors p53 and Rb; cell cycle regulators, cyclins, CDKs, p21WAF1, p27KIP and INK and the checkpoint kinases ATM/ATR; transcription factors NF-kappaB, AP-1, c-Jun, and c-Fos; angiogenic and metastatic factors, VEGF and matrix metalloprotease 2/9; cyclooxygenases for inflammation; and apoptotic and survival regulators, Bax, Bak, PUMA, Noxa, TRAIL, APAF, survivin, Akt, Bcl2 and Bcl-X(L). In addition to its well-documented anti-oxidant properties, there is increasing evidence that resveratrol exhibits pro-oxidant activity under certain experimental conditions, causing oxidative DNA damage that may lead to cell cycle arrest or apoptosis. This review summarizes in vitro mechanistic data available for resveratrol and discusses new potential anti-cancer targets and the antiproliferative mechanisms of resveratrol.

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  • The Mediterranean diet has a well-established anti-inflammatory activity, mainly due to microbiota-derived short chain fatty acids induced by dietary fibre and high intake of omega-3 PUFA and antioxidants.

    “In addition to weight loss, the MD has been reported to have a well-established anti-inflammatory activity, which is mainly due to the microbiota-derived production of short chain fatty acids that are induced by dietary fibre [14] and the high intake of both polyunsaturated fatty acids (PUFA) omega 3 and antioxidants contained in fruits, vegetables, extra-virgin olive oil, and wine [15,16,17].”

    From Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS) (2019) · cites this paper as [15]

    The Introduction (page not supplied) identifies resveratrol as a plant-derived compound found in grapes and other fruits and reports that it inhibits inflammation. The cited paper does not establish that the Mediterranean diet’s anti-inflammatory activity is mainly due to its intake of omega-3 PUFA and antioxidants. The sentence assigns the short-chain fatty acid mechanism to a separate citation [14]. (LLM, conf=0.84)

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Authors
Athar, M., Back, J. H., Kopelovich, L., Bickers, D. R., & Kim, A. L.
Affiliations
  • Columbia University Irving Medical Center (US)
  • National Institutes of Health (US)
Corresponding author
Kim, Arianna L.
ORCID
Venue
Archives of Biochemistry and Biophysics
Publisher
Elsevier BV
Published
2009-06
Volume
486
Issue
2
Pages
95-102
ISSN
0003-9861 (ISSN-L)
DOI
10.1016/j.abb.2009.01.018
PMC
PMC2749321
OpenAlex
W2020433921
Cited by
462
References
3
Citations by year
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FWCI
4.35
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Biochemistry and Biophysics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (R01CA097249, R03CA125855, R01 CA-097249-01)
  • National Institute of Environmental Health Sciences (R01ES015323)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (K01-AR048582-04, K01AR048582)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Keywords
resveratrol, anticancer mechanism, molecular targets, apoptosis, cell cycle regulation, p53, Rb, NF-κB, angiogenesis, metastasis, vascular endothelial growth factor, matrix metalloproteinases, cyclooxygenase, inflammation, pro-oxidant activity, oxidative DNA damage, Bcl-2 family proteins, Akt, antiproliferative activity
MeSH terms
Resveratrol, Breast Neoplasms, Cathepsins, Cell Cycle, Cell Division, Female, Humans, Inflammation, Leukemia, Lymphoma, Male, Neoplasms, Prostatic Neoplasms, Safety, Stilbenes, Transcription Factors, Anticarcinogenic Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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