Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities
Open accessAbstract
Significance: The metabolic syndrome has evolved to be a major health issue globally. The association between genome integrity and metabolic abnormalities is not well understood. Our results indicate that increased DNA damage and persistent activation of the DNA damage response induce adipocyte senescence in DNA polymerase η knockout ( pol η −/− ) mice. Suppression of adipocyte senescence with a p53 inhibitor, pifithrin-α, alleviated metabolic abnormalities in pol η −/− mice. An increase or decrease in DNA damage affected the senescence status of adipocytes accordingly, which was also in concordance with the severity of metabolic abnormalities in the pol η −/− mice. Our current results indicate that reduced genome integrity plays a causative role in provoking adipocyte senescence that leads to development of obesity and insulin resistance.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Blocking p53, a major regulator of senescence, prevents cellular senescence and reduces metabolic abnormalities.
“The prevention of cellular senescence through inhibition of the major senescence regulator p53 attenuates metabolic abnormalities (102, 103).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [102]
In mice given a high-fat diet for 20 weeks, adipose tissue DNA damage and cellular senescence are increased.
“Increased AT DNA damage and resulting cellular senescence have been identified in mice fed a HFD for 20 weeks (102).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [102]
In a mouse model, inducing genomic instability by ablating polymerase η raised the number of senescent adipose tissue cells and worsened adipose tissue dysfunction.
“This study established a strong link between cell senescence and obesity by demonstrating that inducing genomic instability through ablation of polymerase η increased the number of senescent AT cells and exacerbated AT dysfunction.”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [102]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
New methods for calculating metabolic rate with special reference to protein metabolism
Weir, J. B. D. V. (1949) · The Journal of Physiology · doi:10.1113/jphysiol.1949.sp004363 · Cited by 5,608 · see citing works
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214 · see citing works
ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
Burma, S., Chen, B. P., Murphy, M., Kurimasa, A., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100466200 · Cited by 1,954 · see citing works
F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Austyn, J. M., & Gordon, S. (1981) · European Journal of Immunology · doi:10.1002/eji.1830111013 · Cited by 1,580 · see citing works
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works
Obesity and Severe Obesity Forecasts Through 2030
Finkelstein, E. A., Khavjou, O., Thompson, H. F., Trogdon, J. G., Pan, L., Sherry, B., & Dietz, W. H. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.10.026 · Cited by 1,418 · see citing works
A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy
Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V., & Gudkov, A. V. (1999) · Science · doi:10.1126/science.285.5434.1733 · Cited by 1,270 · see citing works
Fat tissue, aging, and cellular senescence
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works
Arsenic-induced oxidative stress and its reversibility
Flora, S. J. S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.008 · Cited by 825 · see citing works
Structure of an IκBα/NF-κB Complex
Jacobs, M. D., & Harrison, S. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81698-0 · Cited by 822 · see citing works
Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L., & Bohr, V. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.026 · Cited by 711 · see citing works
Metformin: An Old But Still the Best Treatment for Type 2 Diabetes
Rojas, L. B. A., & Gomes, M. B. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-6 · Cited by 567 · see citing works
Adaptive immunity in obesity and insulin resistance
Sell, H., Habich, C., & Eckel, J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.114 · Cited by 486 · see citing works
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms
Athar, M., Back, J. H., Kopelovich, L., Bickers, D. R., & Kim, A. L. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.01.018 · Cited by 462 · see citing works
Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., & Hanaoka, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3491 · Cited by 434 · see citing works
Flora, S. D., Izzotti, A., D’Agostini, F., & Balansky, R. M. (2001) · Carcinogenesis · doi:10.1093/carcin/22.7.999 · Cited by 351 · see citing works
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η
Haracska, L., Yu, S.-L., Johnson, R. E., Prakash, L., & Prakash, S. (2000) · Nature Genetics · doi:10.1038/78169 · Cited by 349 · see citing works
Organelle relationships in cultured 3T3-L1 preadipocytes.
Novikoff, A. B., Novikoff, P. M., Rosen, O. M., & Rubin, C. S. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.87.1.180 · Cited by 331 · see citing works
Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates
Bruss, M. D., Khambatta, C. F., Ruby, M. A., Aggarwal, I., & Hellerstein, M. K. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00524.2009 · Cited by 321 · see citing works
Macrophage recruitment in obese adipose tissue
Bai, Y., & Sun, Q. (2015) · Obesity Reviews · doi:10.1111/obr.12242 · Cited by 279 · see citing works
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase
Vartanian, V. L., Lowell, B., Minko, I. G., Wood, T. G., Ceci, J. D., George, S., Ballinger, S. W., Corless, C. L., McCullough, A. K., & Lloyd, R. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507444103 · Cited by 248 · see citing works
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome
Schneider, J. G., Finck, B. N., Ren, J., Standley, K. N., Takagi, M., Maclean, K. H., Bernal‐Mizrachi, C., Muslin, A. J., Kastan, M. B., & Semenkovich, C. F. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.002 · Cited by 234 · see citing works
Delbos, F., Aoufouchi, S., Faili, A., Weill, J., & Reynaud, C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20062131 · Cited by 185 · see citing works
Stable Cellular Senescence Is Associated with Persistent DDR Activation
Fumagalli, M., Rossiello, F., Mondello, C., & d’Adda di Fagagna, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110969 · Cited by 183 · see citing works
The ATM protein is required for sustained activation of NF-κB following DNA damage
Piret, B., Schoonbroodt, S., & Piette, J. (1999) · Oncogene · doi:10.1038/sj.onc.1202541 · Cited by 176 · cited 17× · see citing works
“The primary antibodies used for Western blotting were the following antimouse antibodies: anti-ATM, anti–phospho-γ-H2AX, and anti–Parp-1 antibodies from Cell Signaling Technology; anti–phospho-ATM (Ser1981) and anti–Ki-67 antibodies from Millipore; anti-p53, anti–phospho-p53 (Ser15), anti-p21, anti–phospho-p21, anti–P…”
BackgroundInfluentialDNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria
Karakasilioti, I., Kamileri, I., Chatzinikolaou, G., Kosteas, T., Vergadi, E., Robinson, A. R., Tsamardinos, I., Rozgaja, T. A., Siakouli, S., Tsatsanis, C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.011 · Cited by 137 · see citing works
Sampath, H., Vartanian, V. L., Rollins, M. R., Sakumi, K., Nakabeppu, Y., & Lloyd, R. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051697 · Cited by 132 · see citing works
A Novel Role of DNA Polymerase η in Modulating Cellular Sensitivity to Chemotherapeutic Agents
Chen, Y., Cleaver, J. E., Hanaoka, F., Chang, C., & Chou, K.-M. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0118 · Cited by 122 · see citing works
Self-citationMurdolo, G., Piroddi, M., Luchetti, F., Tortoioli, C., Canonico, B., Zerbinati, C., Galli, F., & Iuliano, L. (2012) · Biochimie · doi:10.1016/j.biochi.2012.12.014 · Cited by 120 · see citing works
Rey, L., Sidorova, J. M., Puget, N., Boudsocq, F., Biard, D. S. F., Monnat, R. J., Cazaux, C., & Hoffmann, J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00115-09 · Cited by 114 · see citing works
Ceppi, P., Novello, S., Cambieri, A., Longo, M., Monica, V., Iacono, M. L., Levra, M. G., Saviozzi, S., Volante, M., Papotti, M. G., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1227 · Cited by 98 · see citing works
Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase η–deficient Mice
Lin, Q., Clark, A. B., McCulloch, S. D., Yuan, T., Bronson, R. T., Kunkel, T. A., & Kucherlapati, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1862 · Cited by 95 · see citing works
Fernyhough, M. E., VIERCK, J. L., Hausman, G., Mir, P. S., Okine, E. K., & Dodson, M. V. (2004) · Cytotechnology · doi:10.1007/s10616-005-2602-0 · Cited by 89 · see citing works
Genetic Risk Profiles for Cancer Susceptibility and Therapy Response
Bartsch, H., Dally, H., Popanda, O., Risch, A., & Schmezer, P. (2007) · Springer eBooks · doi:10.1007/978-3-540-37696-5_2 · Cited by 76 · see citing works
Elmendorf, J. S., Chen, D., & Pessin, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13289 · Cited by 69 · see citing works
Lesion processing: high-fidelity versus lesion-bypass DNA polymerases
Broyde, S. B., Wang, L., Rechkoblit, O., Geacintov, N. E., & Patel, D. J. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.02.004 · Cited by 66 · see citing works
Zhou, W., Chen, Y., Liu, X., Chu, P. G., Loria, S., Wang, Y., Yen, Y., & Chou, K.-M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083978 · Cited by 62 · see citing works
Self-citationTeng, K.-Y., Qiu, M., Li, Z. H., Luo, H., Zeng, Z.-L., Luo, R.-Z., Zhang, H.-Z., Wang, Z., Li, Y., & Xu, R. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-126 · Cited by 61 · see citing works
Human DNA polymerase η activity and translocation is regulated by phosphorylation
Chen, Y., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J., Yen, Y., & Chou, K.-M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808589105 · Cited by 59 · see citing works
Self-citationSampath, H., Batra, A. K., Vartanian, V. L., Carmical, J. R., Prusak, D. J., King, I. B., Lowell, B., Earley, L. F., Wood, T. G., Marks, D. L., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00387.2010 · Cited by 58 · see citing works
Atypical transcriptional regulators and cofactors of PPARγ
Miard, S., & Fajas, L. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802906 · Cited by 48 · see citing works
Thakur, M., Wernick, M., Collins, C. C., Limoli, C. L., Crowley, E., & Cleaver, J. E. (2001) · Genes Chromosomes and Cancer · doi:10.1002/gcc.1186 · Cited by 46 · see citing works
Reevaluation of the role of DNA polymerase θ in somatic hypermutation of immunoglobulin genes
Martomo, S. A., Saribasak, H., Yokoi, M., Hanaoka, F., & Gearhart, P. J. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.04.002 · Cited by 45 · see citing works
Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis
Stallons, L. J., & McGregor, W. G. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/643857 · Cited by 44 · see citing works
Role of DNA Damage in Cardiovascular Disease
Ishida, T., Ishida, M., Tashiro, S., Yoshizumi, M., & Kihara, Y. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-1194 · Cited by 36 · see citing works
Generation and Culture of Mouse Embryonic Fibroblasts
Lei, Y. L. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-481-4_7 · Cited by 33 · see citing works
Katafuchi, A., Sassa, A., Niimi, N., Grúz, P., Fujimoto, H., Masutani, C., Hanaoka, F., Ohta, T., & Nohmi, T. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1095 · Cited by 31 · see citing works
Cleaver, J. E. (2002) · DNA repair · doi:10.1016/s1568-7864(01)00004-0 · Cited by 30 · see citing works
Yang, I.-Y., Hashimoto, K., de Wind, N., Blair, I. A., & Moriya, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806414200 · Cited by 30 · see citing works
Mutation Frequencies and Spectra in DNA Polymerase η–Deficient Mice
Busuttil, R. A., Lin, Q., Stambrook, P. J., Kucherlapati, R., & Vijg, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6274 · Cited by 20 · see citing works
[The role of the DNA damage response in apoptosis and cell senescence].
Korwek, Z., & Alster, O. (2014) · PubMed · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works
Epigenetic regulation of aging: implications for interventions of aging and diseases
Kang, W., Liu, H., Hu, Q., Wang, L., Liu, J., Zheng, Z., Zhang, W., Ren, J., Zhu, F., & Liu, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01211-8 · Cited by 694 · see citing works
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Li, Q., Hagberg, C. E., Silva Cascales, H., Lang, S., Hyvönen, M. T., Salehzadeh, F., Chen, P., Alexandersson, I., Terezaki, E., Harms, M. J., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01501-8 · Cited by 178 · see citing works
Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing
Burton, D. G. A., & Faragher, R. (2018) · Biogerontology · doi:10.1007/s10522-018-9763-7 · Cited by 175 · see citing works
Senescence in Post-Mitotic Cells: A Driver of Aging?
von Zglinicki, T., Wan, T., & Miwa, S. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8048 · Cited by 170 · see citing works
The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders
Liu, Z., Wu, K. K.-L., Jiang, X. X., Xu, A., & Cheng, K. K. Y. (2020) · Clinical Science · doi:10.1042/cs20190966 · Cited by 139 · see citing works
Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem
Evangelou, K., Vasileiou, P. V. S., Papaspyropoulos, A., Hazapis, O. G., Petty, R., Demaria, M., & Gorgoulis, V. G. (2022) · Physiological Reviews · doi:10.1152/physrev.00007.2022 · Cited by 124 · see citing works
Increased cell senescence in human metabolic disorders
Spinelli, R., Baboota, R. K., Gogg, S., Bèguinot, F., Blüher, M., Nerstedt, A., & Smith, U. (2023) · Journal of Clinical Investigation · doi:10.1172/jci169922 · Cited by 117 · see citing works
Adipose tissue as a linchpin of organismal ageing
Nguyen, T., & Corvera, S. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01046-3 · Cited by 106 · see citing works
Cellular senescence and its role in white adipose tissue
Smith, U., Li, Q., Rydén, M., & Spalding, K. L. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00757-x · Cited by 104 · see citing works
He, Y., Zhou, L., Fan, Z., Liu, S., & Fang, W. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0593-y · Cited by 97 · see citing works
Obesity-related kidney disease: Beyond hypertension and insulin-resistance
Arabi, T. Z., Shafqat, A., Sabbah, B. N., Ashraf, N., Shah, H., Abdulkader, H. S., Razak, A., Sabbah, A. N., & Arabi, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1095211 · Cited by 98 · see citing works
Targeting cellular senescence in metabolic disease
Palmer, A. K., Tchkonia, T., & Kirkland, J. L. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101601 · Cited by 75 · see citing works
Dludla, P. V., Nkambule, B. B., Mazibuko-Mbeje, S. E., Nyambuya, T. M., Marcheggiani, F., Cirilli, I., Ziqubu, K., Shabalala, S. C., Johnson, R., Louw, J., et al. (2020) · Antioxidants · doi:10.3390/antiox9121283 · Cited by 69 · see citing works
Yue, D., Zhang, Y., Cheng, L., Ma, J., Xi, Y., Yang, L., Su, C., Shao, B., Huang, A., Xiang, R., et al. (2016) · Scientific Reports · doi:10.1038/srep24430 · Cited by 58 · see citing works
Majora, M., Sondenheimer, K., Knechten, M., Uthe, I., Esser, C., Schiavi, A., Ventura, N., & Krutmann, J. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam7510 · Cited by 56 · see citing works
Livshits, G., & Kalinkovich, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101852 · Cited by 55 · see citing works
The impact of cellular senescence in human adipose tissue
Nerstedt, A., & Smith, U. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00769-4 · Cited by 55 · see citing works
Dludla, P. V., Mazibuko-Mbeje, S. E., Nyambuya, T. M., Mxinwa, V., Tiano, L., Marcheggiani, F., Cirilli, I., Louw, J., & Nkambule, B. B. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104332 · Cited by 54 · see citing works
Liu, Z., Jin, L., Yang, J., Wang, B., Wu, K. K.-L., Hallenborg, P., Xu, A., & Cheng, K. K. Y. (2018) · Diabetes · doi:10.2337/db18-0684 · Cited by 52 · see citing works
Adipose tissue plasticity and the pleiotropic roles of BMP signaling
Qian, S., Tang, Y., & Tang, Q. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100678 · Cited by 52 · see citing works
Lemche, E., Чабан, О., & Lemche, A. V. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00142 · Cited by 49 · see citing works
PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome
Chen, H., Fajol, A., Hoene, M., Zhang, B., Schleicher, E. D., Lin, Y., Calaminus, C., Pichler, B. J., Weigert, C., Häring, H. U., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601355113 · Cited by 47 · see citing works
Senolytics: Potential for Alleviating Diabetes and Its Complications
Palmer, A. K., Tchkonia, T., & Kirkland, J. L. (2021) · Endocrinology · doi:10.1210/endocr/bqab058 · Cited by 49 · see citing works
Iwasaki, K., Abarca, C., & Aguayo‐Mazzucato, C. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0416 · Cited by 48 · see citing works
Distinct adipose progenitor cells emerging with age drive active adipogenesis
Wang, G., Li, G., Song, A., Zhao, Y., Yu, J., Wang, Y., Dai, W., Salas, M. C., Qin, H., Medrano, L. J., et al. (2025) · Science · doi:10.1126/science.adj0430 · Cited by 46 · see citing works
Twayana, S., Bacolla, A., Barreto-Galvez, A., De-Paula, R. B., Drosopoulos, W. C., Kosiyatrakul, S. T., Bouhassira, E., Tainer, J., Madireddy, A., & Schildkraut, C. (2021) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2106477118 · Cited by 43 · see citing works
Fano, M. D., Bartolini, D., Tortoioli, C., Vermigli, C., Malara, M., Galli, F., & Murdolo, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105511 · Cited by 44 · see citing works
Cellular Senescence in Obesity and Associated Complications: a New Therapeutic Target
Narasimhan, A., Flores, R. R., Camell, C. D., Bernlohr, D., Robbins, P. D., & Niedernhofer, L. J. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01493-w · Cited by 39 · see citing works
A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats
Geng, L., Zhang, B., Liu, H., Wang, S., Cai, Y., Yang, K., Zou, Z., Jiang, X., Liu, Z., Li, W., et al. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac045 · Cited by 37 · see citing works
Enhanced expression of Survivin has distinct roles in adipocyte homeostasis
Ju, L., Zhang, X., Deng, Y., Han, J., Yang, J., Chen, S., Fang, Q., Yang, Y., & Jia, W. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.439 · Cited by 36 · see citing works
Understanding the Role of Adipokines in Cardiometabolic Dysfunction: A Review of Current Knowledge
Datta, S., Koka, S., & Boini, K. M. (2025) · Biomolecules · doi:10.3390/biom15050612 · Cited by 32 · see citing works
Sjakste, N., & Riekstiņa, U. (2021) · European Journal of Histochemistry · doi:10.4081/ejh.2021.3236 · Cited by 30 · see citing works
An, Y., Yu, R., Liu, H., Ge, C., & Dang, W. (2023) · GeroScience · doi:10.1007/s11357-023-00863-w · Cited by 28 · see citing works
Polymerase η Recruits DHX9 Helicase to Promote Replication across Guanine Quadruplex Structures
Tang, F., Wang, Y.-N., Gao, Z., Guo, S., & Wang, Y.-S. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c05312 · Cited by 25 · see citing works
Bima, A. I. H., Mahdi, A. S., Fayez, F. F. A., Khawaja, T. M., El‐khair, S. M. A., & Elsamanoudy, A. Z. (2021) · Cells · doi:10.3390/cells10040920 · Cited by 24 · see citing works
Zhou, Z., Zhang, H., Tao, Y., Jie, H., Zhao, J., Zang, J., Li, H., Wang, Y., Wang, T., Zhao, H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112424 · Cited by 22 · see citing works
The multifaceted roles of DNA repair and replication proteins in aging and obesity
D’Amico, A. M., & Vásquez, K. M. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103049 · Cited by 21 · see citing works
Secretion of miRNA-326-3p by senescent adipose exacerbates myocardial metabolism in diabetic mice
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. F. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03484-7 · Cited by 21 · see citing works
Guevara, A., McGowan, S. J., Kazantzis, M., Stallons, T. A. R., Sano, T., Mulder, N. L., Jurdzinski, A., van Dijk, T. H., Eggen, B. J. L., Jonker, J. W., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154711 · Cited by 18 · see citing works
Characteristic and fate determination of adipose precursors during adipose tissue remodeling
Ye, J., Gao, C. D., Liang, Y., Hou, Z., Shi, Y., & Wang, Y. (2023) · Cell Regeneration · doi:10.1186/s13619-023-00157-8 · Cited by 18 · see citing works
Understanding the Impact of Obesity on Ageing in the Radiance of DNA Metabolism
Chowdhury, S. G., Misra, S., & Karmakar, P. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1912-1 · Cited by 17 · see citing works
Adipose tissue senescence: Biological changes, hallmarks and therapeutic approaches
Zhang, Y., Jiang, Y., Yang, X., Huang, Y., Pan, A., & Liao, Y. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111988 · Cited by 16 · see citing works
Luca, M. D., Mandalà, M., & Rose, G. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111522 · Cited by 16 · see citing works
Bima, A. I. H., Eldakhakhny, B. M., Nuwaylati, D. A., Alnami, A., Ajabnoor, M. A., & Elsamanoudy, A. Z. (2021) · Nutrients · doi:10.3390/nu13114127 · Cited by 15 · see citing works
Panhuis, W. I. H., Tsaalbi‐Shtylik, A., Schönke, M., van Harmelen, V., Pronk, A. C. M., Streefland, T. C. M., Sips, H. C. M., Afkir, S., van Dijk, K. W., Rensen, P. C. N., et al. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00357.2021 · Cited by 13 · see citing works
De Fano, M., Bartolini, D., Tortoioli, C., Vermigli, C., Malara, M., Galli, F., & Murdolo, G. (2022) · doi:10.20944/preprints202204.0011.v1 · Cited by 41 · see citing works
How to measure and model cardiovascular aging
Spray, L., Richardson, G. D., Booth, L. K., Haendeler, J., Altschmied, J., Bromage, D. I., Wallis, S. B., Stellos, K., Tual‐Chalot, S., & Spyridopoulos, I. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf138 · Cited by 13 · see citing works
DNA damage, inflammation and aging: Insights from mice
Arvanitaki, E. S., Stratigi, K., & Garinis, G. A. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.973781 · Cited by 12 · see citing works
Lino, C. A., Silva, T. D. O., Lunardon, G., Balbino-Silva, C., Lima, V. M., Huang, Z.-P., Donato, J., Takano, A. P. C., Barreto‐Chaves, M. L. M., Wang, D., et al. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111775 · Cited by 11 · see citing works
Zhao, W. M., Xu, Q., Yang, J., Xie, X., Li, C., Zhang, W., Chen, E., Guo, Y., Gao, M., Shi, J., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104544 · Cited by 12 · see citing works
Senescent adipocytes and type 2 diabetes – current knowledge and perspective concepts
Kruczkowska, W., Gałęziewska, J., Kciuk, M., Gielecińska, A., Płuciennik, E., Pasieka, Z. W., Zhao, L.-Y., Yu, Y.-J., Kołat, D., & Kałuzińska‐Kołat, Ż. (2024) · BioMolecular Concepts · doi:10.1515/bmc-2022-0046 · Cited by 12 · see citing works
Feng, J., Xu, H.-Q., Pan, F., Hu, J., Wu, Y., Lin, N., Zhang, X., Ji, C., Hu, Y., Zhong, H., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00046 · Cited by 10 · see citing works
Senescent cells in the development of cardiometabolic disease
Postmus, A. C., Sturmlechner, I., Jonker, J. W., van Deursen, J. M., van de Sluis, B., & Kruit, J. K. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000602 · Cited by 10 · see citing works
Nontraditional Roles of DNA Polymerase Eta Support Genome Duplication and Stability
Eckert, K. A. (2023) · Genes · doi:10.3390/genes14010175 · Cited by 9 · see citing works
Molecular and Cellular Aspects of Macrophage Aging
Lloberas, J., Tur, J., Vico, T., & Celada, A. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_46 · Cited by 9 · see citing works
Muhamadejevs, R., Živković, L., Dzintare, M., & Sjakste, N. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109638 · Cited by 7 · see citing works
Wahlmueller, M., Narzt, M., Strohmeier, K., Arminger, V., Krasensky, A., Lämmermann, I., Schaedl, B., Mairhofer, M., Suessner, S., Wolbank, S., et al. (2022) · Life · doi:10.3390/life12101459 · Cited by 5 · see citing works
Luo, H., Chen, L., Cui, Z., Du, J., Yang, H., Qiu, W., Zhai, L., Liang, H., & Tang, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113259 · Cited by 6 · see citing works
Radomska-Leśniewska, D. M., Niderla‐Bielińska, J., Kujawa, M., & Jankowska-Steifer, E. A. (2025) · Metabolites · doi:10.3390/metabo15100645 · Cited by 5 · see citing works
Ex vivo Anti-Senescence Activity of N-Acetylcysteine in Visceral Adipose Tissue of Obese Volunteers
Behtaj, D., Ghorbani, A., Eslamian, G., Alamdari, N. M., Abbasi, M., Zand, H., Shakery, A., Shimi, G., Sohouli, M. H., & Taherian, S. F. (2024) · Obesity Facts · doi:10.1159/000539255 · Cited by 5 · see citing works
The role of cellular senescence in wound healing of diabetic skin
Ueda, N., Saito, Y., Ota, K., Nagao, A., Kasseki, D., & Chikenji, T. (2026) · The Journal of Biochemistry · doi:10.1093/jb/mvag006 · Cited by 4 · see citing works
Transcription factor HBP1: A regulator of senescence and apoptosis of preadipocytes
Chen, H., Liu, C., Liu, Y., Li, H., & Cheng, B. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.07.048 · Cited by 4 · see citing works
Li, Y., Wang, B., Wang, Z., Wen, J., Zhou, T., Tang, J., & Li, Z. (2025) · Animals · doi:10.3390/ani15070951 · Cited by 3 · see citing works
Depletion of ASK1 blunts stress-induced senescence in adipocytes
Wueest, S., Lucchini, F. C., Haim, Y., Rudich, A., & Konrad, D. (2020) · Adipocyte · doi:10.1080/21623945.2020.1815977 · Cited by 3 · see citing works
Senescence detection using reflected light
Dedic, B., Westerberg, L. J. S., Solís, A. M., Dumont, K. D., Ruas, J. L., Thorell, A., Näslund, E. B., & Spalding, K. L. (2024) · Aging Cell · doi:10.1111/acel.14295 · Cited by 3 · see citing works
A unique adipocyte progenitor population promotes age-related adiposityPreprint
Wang, Q. A., Wang, G., Li, G., Song, A., Dai, W., Shamlin, N. P., Qin, H., Medrano, L. J., Dow, J., Li, A., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-888694/v1 · Cited by 3 · see citing works
Tsao, W.-C., Buj, R., Aird, K. M., Sidorova, J. M., & Eckert, K. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251188 · Cited by 2 · see citing works
DNA repair-related genes and adipogenesis: Lessons from congenital lipodystrophies
Campos, J. T. A. D. M., de Oliveira, M. S., Soares, L. P., de Medeiros, K. A., Campos, L. R. D. S., & Lima, J. G. (2022) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2022-0086 · Cited by 2 · see citing works
Genetic and Epigenetic Influences on Cutaneous Cellular Senescence
Sarkar, T. J., Hermsmeier, M., Ross, J. L., & Herron, G. S. (2021) · Physiology · doi:10.5772/intechopen.101152 · Cited by 1 · see citing works
Leptin A deficiency affecting the mitochondrial dynamics of aged oocytes in medaka (Oryzias latipes)
Yang, J., Wang, Y., Wang, G., Guo, Z., Li, X., Lu, J., Tu, H., Li, S., Wan, J., Guan, G., et al. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112345 · Cited by 1 · see citing works
Palmer, A. K., & Kirkland, J. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00012-8 · Cited by 1 · see citing works
Molecular and Cellular Aspects of Macrophage Aging
Lloberas, J., Tur, J., Vico, T., & Celada, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_46-1 · Cited by 1 · see citing works
Interactions between DNA damage and metabolism
Guevara, A. (2020) · doi:10.33612/diss.123699652
Tsao, W.-C., Buj, R., Aird, K. M., Sidorova, J. M., & Eckert, K. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.01.180455
Çolak, D. K., Coşkun, Z. M., & Bolkent, S. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3894
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115869
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115878
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115863
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115860
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115872
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115866
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115875
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115881
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115857
- Authors
- Chen, Y.-W., Harris, R. A., Hatahet, Z., & Chou, K.-M.
- Affiliations
- Indiana University Indianapolis (US)
- Richard L. Roudebush VA Medical Center (US)
- Northwestern State University (US)
- ORCID
- Harris, Robert A.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-08-03
- Volume
- 112
- Issue
- 33
- Pages
- E4556-64
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4547227
- OpenAlex
- W2146336603
- Cited by
- 86
- References
- 57
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 24 · 2021: 16 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 3
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- PMC
- Funders
- HHS | NIH | National Cancer Institute (112446)
- U.S. Department of Veterans Affairs (BLRD Merit Award)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adipocyte senescence, adipose tissue, obesity, insulin resistance, DNA damage response, p53, pifithrin-alpha, metabolic syndrome, hepatic steatosis, hyperleptinemia, hyperinsulinemia, impaired glucose tolerance, high-fat diet, sodium arsenite, N-acetylcysteine, metformin, interleukin-6, TNF-α, senescence-associated β-galactosidase
- MeSH terms
- Y-Family DNA Polymerases, Adipose Tissue, Animals, Blood Glucose, DNA Damage, DNA-Directed DNA Polymerase, Genotype, Immunohistochemistry, Insulin Resistance, Macrophages, Male, Neoplasm Transplantation, Toluene, Gene Expression Regulation, Neoplastic, Cellular Senescence, Reactive Oxygen Species, Adipocytes, Mice, Knockout, Comet Assay, Metabolic Syndrome, 3T3-L1 Cells, Mice, Benzothiazoles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review