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Microfluidics for cell-based high throughput screening platforms—A review

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Du, Guansheng, Fang, Qun, den Toonder, Jaap M.J.·2016·Analytica Chimica Acta

DOI 10.1016/j.aca.2015.11.023

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Abstract

In the last decades, the basic techniques of microfluidics for the study of cells such as cell culture, cell separation, and cell lysis, have been well developed. Based on cell handling techniques, microfluidics has been widely applied in the field of PCR (Polymerase Chain Reaction), immunoassays, organ-on-chip, stem cell research, and analysis and identification of circulating tumor cells. As a major step in drug discovery, high-throughput screening allows rapid analysis of thousands of chemical, biochemical, genetic or pharmacological tests in parallel. In this review, we summarize the application of microfluidics in cell-based high throughput screening. The screening methods mentioned in this paper include approaches using the perfusion flow mode, the droplet mode, and the microarray mode. We also discuss the future development of microfluidic based high throughput screening platform for drug discovery.

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Authors: Du, G., Fang, Q., & den Toonder, J. M. J.
Affiliations: Zhejiang University (CN)
Corresponding author: Fang, Qun
ORCID: Fang, Qun
Venue: Analytica Chimica Acta
Publisher: Elsevier BV
Published: 2016-01
Volume: 903
Pages: 36-50
ISSN: 0003-2670 (ISSN-L)
DOI: 10.1016/j.aca.2015.11.023
OpenAlex: W2175894202
Semantic Scholar: 19c0d49efc26c0f85b416a428d8d90b8d69be2e7
Cited by: 276
References: 81
Citations by year: 2026: 11 · 2025: 14 · 2024: 29 · 2023: 21 · 2022: 31 · 2021: 36 · 2020: 37 · 2019: 31 · 2018: 31 · 2017: 27 · 2016: 8
FWCI: 1.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Analytica Chimica Acta (publishedVersion)
PubMed (publishedVersion)
TU/e Research Portal (submittedVersion, other-oa)
TU/e Research Portal (submittedVersion)
Funders: National Natural Science Foundation of China (20825517, 21227007, 21435004)
Major National Science and Technology Programs (2013ZX09507005)
Philips Research
Topics: Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Innovative Microfluidic and Catalytic Techniques Innovation
Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
Keywords: microfluidics, cell-based high-throughput screening, drug discovery, droplet microfluidics, microarray, organ-on-a-chip, cell isolation, circulating tumor cells, stem cell research, immunoassay, PCR
MeSH terms: Microfluidics, High-Throughput Screening Assays

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Microfluidics for cell-based high throughput screening platforms—A review

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