Executive function deficits in early Alzheimer's disease and their relations with episodic memory
Abstract
Previous research suggests that patients with Alzheimer's disease (AD) are impaired on executive function early in the course of disease, but negative findings were reported. To evaluate the performance on executive tasks in early AD and to determine the involvement of memory on the outcome of executive tasks. Thirty-six AD patients were divided into two subgroups on the basis of the MMSE: very mild and mild. The comparison with 17 normal controls shows that very mild AD patients had deficits on visuospatial short-term memory, episodic memory, flexibility and self-monitoring abilities, concept formation and reasoning. The mild AD patients showed additional deficits on the Similarities test. Episodic memory and executive deficits occur in the very early stage of AD and precede impairment in constructional praxis, language and sustained attention. With the progression of the disease, additional deficit is observed in abstract thinking. In mild AD, memory failure is also related to executive impairment.
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Language problems and impairment in executive functions typically emerge in the early to middle stages of AD.
“Language problems and impairment in executive functions typically emerge in the early to middle stages of AD (68, 69).”
From Comprehensive characterization of the transcriptional landscape in Alzheimer’s disease (AD) brains (2025) · cites this paper as [69]
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“Language problems and impairment in executive functions typically emerge in the early to middle stages of AD ( 68 , 69 ).”
- Authors
- BAUDIC, S., BARBA, G., THIBAUDET, M., SMAGGHE, A., REMY, P., & TRAYKOV, L.
- Affiliations
- Inserm (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Université Paris-Est Créteil (FR)
- Corresponding author
- BAUDIC, S
- ORCID
- BAUDIC, S
- Venue
- Archives of Clinical Neuropsychology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-01
- Volume
- 21
- Issue
- 1
- Pages
- 15-21
- ISSN
- 0887-6177 (ISSN-L)
- OpenAlex
- W1983850663
- Cited by
- 391
- References
- 2
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 19 · 2023: 13 · 2022: 25 · 2021: 19 · 2020: 41 · 2019: 26 · 2018: 34 · 2017: 21 · 2016: 28 · 2015: 15 · 2014: 14 · 2013: 21 · 2012: 16
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Clinical Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- Alzheimer's disease, early Alzheimer's disease, executive dysfunction, episodic memory, visuospatial short-term memory, cognitive flexibility, self-monitoring, concept formation, reasoning, Mini-Mental State Examination, mild cognitive impairment, disease progression
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Attention, Cognition, Female, Humans, Male, Memory, Neuropsychological Tests, Severity of Illness Index, Verbal Behavior, Visual Perception, Case-Control Studies
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