The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Gradient collagen/nanohydroxyapatite composite scaffold: Development and characterization
Open accessAbstract
This paper reports an in situ diffusion method for the fabrication of compositionally graded collagen/nanohydroxyapatite (HA) composite scaffold. The method is diffusion based and causes the precipitation of nano-HA crystallites in situ. A collagen matrix acts as a template through which calcium ions (Ca(2+)) and phosphate ions (PO4(3-)) diffuse and precipitate a non-stoichiometric HA. It was observed that needle-like prismatic nano-HA crystallites (about 2 x 2 x 20 nm) precipitated in the interior of the collagen template onto the collagen fibrils. Chemical and microstructural analysis revealed a gradient of the Ca to P ratio across the width of the scaffold template, resulting in the formation of a Ca-rich side and a Ca-depleted side of scaffold. The Ca-rich side featured low porosity and agglomerates of the nano-HA crystallites, while the Ca-depleted side featured higher porosity and nano-HA crystallites integrated with collagen fibrils to form a porous network structure.
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“A Ca-rich scaffold with interconnected porous structure was developed which facilitates cell attachment and proliferation.[111]”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [111]
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Cites
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1 of the 45 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
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Items 101–109 of 109
Gradient Biomaterials as Tissue Scaffolds
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Metadata
- Authors
- Liu, C., Han, Z., & Czernuszka, J. T.
- Affiliations
- University of Oxford (GB)
- Jilin University (CN)
- Corresponding author
- Liu, Chaozong
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 5
- Issue
- 2
- Pages
- 661-669
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2059421614
- Cited by
- 109
- References
- 45
- Citations by year
- 2024: 3 · 2023: 6 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 16
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust (074486)
- University of Oxford
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- gradient scaffolds, calcium phosphate precipitation, collagen fibrils, porous scaffolds, scaffold porosity
- MeSH terms
- Animals, Cattle, Collagen, Hydrogen-Ion Concentration, Spectrum Analysis, Tomography, X-Ray Computed, X-Rays, Durapatite, Microscopy, Electron, Transmission, Nanoparticles
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