Cited by 430Bone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applicationsbiodegradable polymer synthesis and properties

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Electrospun nanostructured scaffolds for bone tissue engineering

Prabhakaran, Molamma P., Venugopal, J., Ramakrishna, S.·2009·Acta Biomaterialia

DOI 10.1016/j.actbio.2009.05.007

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Abstract

The current challenge in bone tissue engineering is to fabricate a bioartificial bone graft mimicking the extracellular matrix (ECM) with effective bone mineralization, resulting in the regeneration of fractured or diseased bones. Biocomposite polymeric nanofibers containing nanohydroxyapatite (HA) fabricated by electrospinning could be promising scaffolds for bone tissue engineering. Nanofibrous scaffolds of poly-l-lactide (PLLA, 860+/-110 nm), PLLA/HA (845+/-140 nm) and PLLA/collagen/HA (310+/-125 nm) were fabricated, and the morphology, chemical and mechanical characterization of the nanofibers were evaluated using scanning electron microscopy, Fourier transform infrared spectroscopy and tensile testing, respectively. The in vitro biocompatibility of different nanofibrous scaffolds was also assessed by growing human fetal osteoblasts (hFOB), and investigating the proliferation, alkaline phosphatase activity (ALP) and mineralization of cells on different nanofibrous scaffolds. Osteoblasts were found to adhere and grow actively on PLLA/collagen/HA nanofibers with enhanced mineral deposition of 57% higher than the PLLA/HA nanofibers. The synergistic effect of the presence of an ECM protein, collagen and HA in PLLA/collagen/HA nanofibers provided cell recognition sites together with apatite for cell proliferation and osteoconduction necessary for mineralization and bone formation. The results of our study showed that the biocomposite PLLA/collagen/HA nanofibrous scaffold could be a potential substrate for the proliferation and mineralization of osteoblasts, enhancing bone regeneration.

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Authors: Prabhakaran, M. P., Venugopal, J., & Ramakrishna, S.
Affiliations: National University of Singapore (SG)
Corresponding author: Prabhakaran, Molamma P.
ORCID: Prabhakaran, Molamma P.
Venugopal, J.
Ramakrishna, S.
Venue: Acta Biomaterialia
Publisher: Elsevier BV
Published: 2009-10
Volume: 5
Issue: 8
Pages: 2884-2893
ISSN: 1742-7061 (ISSN-L)
DOI: 10.1016/j.actbio.2009.05.007
OpenAlex: W2070366856
Cited by: 430
References: 35
Citations by year: 2026: 10 · 2025: 11 · 2024: 23 · 2023: 16 · 2022: 24 · 2021: 17 · 2020: 42 · 2019: 31 · 2018: 23 · 2017: 36 · 2016: 34 · 2015: 25 · 2014: 34 · 2013: 30 · 2012: 30
FWCI: 14.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Acta Biomaterialia (publishedVersion)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
Funders: National Medical Research Council
Topics: Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords: electrospun nanofibers, bone tissue engineering, poly(L-lactic acid), hydroxyapatite nanoparticles, collagen, biocomposite scaffolds, osteoblast mineralization, alkaline phosphatase activity, osteoblast proliferation, bone regeneration, extracellular matrix mimicry, osteoconduction
MeSH terms: Absorption, Cell Line, Electrochemistry, Extracellular Matrix, Humans, Materials Testing, Osteoblasts, Osteogenesis, Particle Size, Polyesters, Polymers, Rotation, Surface Properties, Porosity, Bone Substitutes, Cell Culture Techniques, Lactic Acid, Tissue Engineering, Biomimetic Materials, Cell Enlargement, Nanostructures

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Electrospun nanostructured scaffolds for bone tissue engineering

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