Thermoplastic biodegradable elastomers based on ε-caprolactone and l-lactide block co-polymers: A new synthetic approach
Open accessAbstract
Although biodegradable polymers have found extensive application in medical devices, there are very few commercially available elastomeric biodegradable polymers. In this work, starting with the well-known monomers L-lactide and ε-caprolactone, we developed elastomers using a multiblock co-polymer approach. This ensures that the degradation products of such elastomers are also acceptable from a cytotoxicity standpoint. A series of polymers with various structures was synthesized utilizing a design of experiment approach. The basic structure is that of a diblock, with each block being modified by the addition of co-monomer. The synthesized polymers exhibited a range of mechanical properties from a typical thermoplastic polymer to that approaching a good thermoplastic elastomer. 13C nuclear magnetic resonance analysis, size exclusion chromatography and differential scanning calorimetry measurements have been utilized to relate the observed range of mechanical properties to the structure. In addition, the elastomeric nature has been established with the use of creep and recovery measurements. Such elastomers may find a variety of biomedical applications, ranging from stent coatings to atrial septal defect occluders.
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PLA-b-PCL copolymer has improved toughness but decreased tensile strength and Young's modulus compared with pure PLA.
“Biodegradable but brittle polylactide (PLA) can be toughened by copolymerizing with poly caprolactone (PCL). However, the tensile strength and Young's modulus dramatically decrease compared with pure PLA.”
From Simultaneously Toughening and Strengthening of PLA-b-PCL Copolymer via Pressure-induced-flow Processing at Room Temperature (2018) · cites this paper as [15]
Section 3.1 describes making PLA–PCL copolymers elastomeric, and Section 3.2, Table 1 reports high elongation at break and low Young’s modulus for the copolymers. The paper does not report a pure-PLA mechanical control or establish that the copolymers have lower tensile strength and Young’s modulus than pure PLA. (LLM, conf=0.86)
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- Authors
- Lipik, V. T., Kong, J. F., Chattopadhyay, S., Widjaja, L. K., Liow, S. S., Venkatraman, S. S., & Abadie, M. J. M.
- Affiliations
- Nanyang Technological University (SG)
- Corresponding author
- Venkatraman, Subbu S.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 6
- Issue
- 11
- Pages
- 4261-4270
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2128757440
- Cited by
- 27
- References
- 18
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
- Keywords
- ε-caprolactone, L-lactide, multiblock copolymers, diblock copolymers, structure-property relationships, mechanical properties, creep and recovery, cytotoxicity, stent coating, atrial septal defect occluder, biodegradable polymers
- MeSH terms
- Biocompatible Materials, Calorimetry, Differential Scanning, Crystallization, Materials Testing, Molecular Weight, Magnetic Resonance Spectroscopy, Plastics, Polyesters, Temperature, Elastomers, Elastic Modulus
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