The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Injectable hydrogel scaffold from decellularized human lipoaspirate
Open accessAbstract
Soft tissue fillers are rapidly gaining popularity for aesthetic improvements or repair of adipose tissue deficits. Several injectable biopolymers have been investigated for this purpose but often face rapid resorption or limited adipogenesis, and do not mimic the native adipose extracellular matrix (ECM). We have generated an injectable adipose matrix scaffold by efficiently removing both the cellular and lipid contents of human lipoaspirate. The decellularized material retained a complex composition of peptides and glycosaminoglycans found in native adipose ECM. This matrix can be further processed by solubilizing the extracted ECM to generate a thermally-responsive hydrogel that self-assembles upon subcutaneous injection. This hydrogel also supports the growth and survival of patient matched adipose - derived stem cells in vitro. The development of an injectable hydrogel from human lipoaspirate represents a minimally-invasive option for adipose tissue engineering in terms of both the collection of source material and delivery of the scaffold.
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Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
Decellularization of tissues and organs
Gilbert, T. W., Sellaro, T. L., & Badylak, S. F. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.014 · Cited by 2,222
Cited by
Self-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 892
A hydrogel derived from decellularized dermal extracellular matrix
Wolf, M. T., Daly, K. A., Brennan-Pierce, E. P., Johnson, S. A., Carruthers, C. A., D'Amore, A., Nagarkar, S. P., Velankar, S. S., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.051 · Cited by 482
Biomimetic 3D tissue printing for soft tissue regeneration
Pati, F., Ha, D.-H., Jang, J., Han, H. H., Rhie, J.-W., & Cho, D.-W. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.05.043 · Cited by 368
Porzionato, A., Stocco, E., Barbon, S., Grandi, F., Macchi, V., & De Caro, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124117 · Cited by 319
Extracellular matrix hydrogel therapies: In vivo applications and development
Spang, M. T., & Christman, K. L. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.12.019 · Cited by 304
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Metadata
- Authors
- Young, D. A., Ibrahim, D. O., Hu, D., & Christman, K. L.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 7
- Issue
- 3
- Pages
- 1040-1049
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W1997671734
- Cited by
- 213
- References
- 3
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Young, D. A., Ibrahim, D. O., Hu, D., & Christman, K. L. (2011). Injectable hydrogel scaffold from decellularized human lipoaspirate. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2010.09.035
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