The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Titanium surface characteristics, including topography and wettability, alter macrophage activation
Open accessAbstract
Biomaterial surface properties including chemistry, topography, and wettability regulate cell response. Previous studies have shown that increasing surface roughness of metallic orthopaedic and dental implants improved bone formation around the implant. Little is known about how implant surface properties can affect immune cells that generate a wound healing microenvironment. The aim of our study was to examine the effect of surface modifications on macrophage activation and cytokine production. Macrophages were cultured on seven surfaces: tissue culture polystyrene (TCPS) control; hydrophobic and hydrophilic smooth Ti (PT and oxygen-plasma-treated (plasma) PT); hydrophobic and hydrophilic microrough Ti (SLA and plasma SLA), and hydrophobic and hydrophilic nano-and micro-rough Ti (aged modSLA and modSLA). Smooth Ti induced inflammatory macrophage (M1-like) activation, as indicated by increased levels of interleukins IL-1β, IL-6, and TNFα. In contrast, hydrophilic rough titanium induced macrophage activation similar to the anti-inflammatory M2-like state, increasing levels of interleukins IL-4 and IL-10. These results demonstrate that macrophages cultured on high surface wettability materials produce an anti-inflammatory microenvironment, and this property may be used to improve the healing response to biomaterials.
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Cites
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“The importance of the interaction of immune cells and biomaterial surface has been previously established [27].”
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Cited by
Nano-scale modification of titanium implant surfaces to enhance osseointegration
Souza, J. C. M., Sordi, M. B., Kanazawa, M., Ravindran, S., Henriques, B., Silva, F. S., Aparicio, C., & Cooper, L. F. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.045 · Cited by 544
Current Advances in Immunomodulatory Biomaterials for Bone Regeneration
Lee, J., Byun, H., Madhurakkat Perikamana, S. K., Lee, S., & Shin, H. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801106 · Cited by 452
Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers
Klopfleisch, R. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.003 · Cited by 298
Bai, L., Du, Z., Du, J., Yao, W., Zhang, J., Weng, Z., Liu, S., Zhao, Y., Liu, Y., Zhang, X., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.010 · Cited by 265
Macrophages and bone inflammation
Gu, Q., Yang, H., & Shi, Q. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.05.002 · Cited by 221
Metadata
- Authors
- Hotchkiss, K. M., Reddy, G. B., Hyzy, S. L., Schwartz, Z., Boyan, B. D., & Olivares-Navarrete, R.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 31
- Pages
- 425-434
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2193505608
- Cited by
- 680
- References
- 9
- FWCI
- 14.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Hotchkiss, K. M., Reddy, G. B., Hyzy, S. L., Schwartz, Z., Boyan, B. D., & Olivares-Navarrete, R. (2016). Titanium surface characteristics, including topography and wettability, alter macrophage activation. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2015.12.003
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