Platelet-mimicking nanoparticles co-loaded with W18O49 and metformin alleviate tumor hypoxia for enhanced photodynamic therapy and photothermal therapy
Open accessAbstract
W 18 O 49 -mediated photodynamic therapy (PDT) and photothermal therapy (PTT) are limited by the easily oxidized property and tumor hypoxia. Here, we report the development of platelet membranes as nanocarriers to co-load W 18 O 49 nanoparticles (NPs) and metformin (PM-W 18 O 49 -Met NPs). Platelet membranes can protect W 18 O 49 from oxidation and immune evasion, and increase the accumulation of W 18 O 49 in tumor sites via the passive EPR effect and active adhesion between platelets and cancer cells. The introduction of metformin (Met), a typical anti-diabetic drug, can alleviate the tumor hypoxia through reducing oxygen consumption. As a result, ROS and heat generation are both greatly increased, as revealed by ROS/hypoxia imaging in vitro , IR thermal imaging in vivo and PET imaging in vivo . PM-W 18 O 49 -Met NPs show the improved therapeutic effects with greatly inhibited tumor growth and induced tumor cell apoptosis. Therefore, our work provides a novel strategy for simultaneous enhanced PDT and PTT, which is promising in bioapplication. Statemente of Significance W 18 O 49 -mediated photodynamic therapy and photothermal therapy are limited by the poor delivery of nanoparticles to tumors, the easily oxidized property, and tumor hypoxia environment, which will induce tumor treatment failure. Herein, we report the development of platelet membranes as nanocarriers to co-load W 18 O 49 nanoparticles and metformin (PM-W 18 O 49 -Met NPs). Platelet membranes can protect W 18 O 49 from oxidation and immune evasion, and increase the accumulation of W 18 O 49 in tumor sites via the passive EPR effect and active adhesion. Metformin can alleviate the tumor hypoxia through reducing oxygen consumption. Hence, ROS and heat generation are both greatly increased. PM-W 18 O 49 -Met NPs show the improved therapeutic effects with greatly inhibited tumor growth and induced apoptosis. Therefore, our work provides a novel strategy in bioapplication.
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Metformin alleviates tumor hypoxia by reducing oxygen consumption by inhibiting complex I in the mitochondrial electron transport chain.
“In addition, studies have shown that metformin (Met), a typical antidiabetic drug, also alleviates tumor hypoxia by reducing oxygen consumption by inhibiting complex I in the mitochondrial electron transport chain.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [276]
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- Authors
- Zuo, H., Tao, J., Shi, H., He, J., Zhou, Z., & Zhang, C.
- Affiliations
- Nanjing Drum Tower Hospital (CN)
- Northern Jiangsu People's Hospital (CN)
- Nanjing University (CN)
- Corresponding author
- He, Jian
- Zhou, Zhengyang
- Zhang, Chao
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 80
- Pages
- 296-307
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2891218377
- Cited by
- 170
- References
- 36
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 35 · 2023: 26 · 2022: 24 · 2021: 30 · 2020: 20 · 2019: 15
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Acta Biomaterialia (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province (BK20150109)
- Six Talent Peaks Project in Jiangsu Province (2015-WSN-079)
- Jiangsu Provincial Commission of Health and Family Planning (Q201508)
- Nanjing Medical Science and Technique Development Foundation (QRX11178, YKK15067)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- metformin, tumor hypoxia, photodynamic therapy, photothermal therapy, co-loading, oxidation protection, immune evasion, enhanced permeability and retention effect, reactive oxygen species, tumor growth inhibition, apoptosis
- MeSH terms
- Tumor Hypoxia, Animals, Antineoplastic Agents, Blood Platelets, Body Weight, Humans, Hyperthermia, Induced, Lymphoma, Metformin, Mice, Inbred BALB C, Mice, Nude, Oxides, Oxygen Consumption, Photochemotherapy, Tungsten, Biomimetic Materials, Cell Line, Tumor, Positron-Emission Tomography, Nanoparticles
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