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Cited by 378

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects

Thapa, Raj Kumar, Diep, Dzung B., Tønnesen, Hanne Hjorth·2020·Acta Biomaterialia
DOI 10.1016/j.actbio.2019.12.025
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Abstract

Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their potent antibacterial and wound healing properties. Bare AMPs have limited activity following topical application attributable to their susceptibility to environment (hydrolysis, oxidation, photolysis), and wound (alkaline pH, proteolysis) related factors as well as minimal residence time. Therefore, the formulation of AMPs is essential to enhance stability, prolong delivery, and optimize effectiveness at the wound site. Different topical formulations of AMPs have been developed so far including nanoparticles, hydrogels, creams, ointments, and wafers to aid in controlling bacterial infection and enhance wound healing process in vivo. Herein, an overview is provided of the AMPs and current understanding of their formulations for topical wound healing applications along with suitable examples. Furthermore, future prospects for the development of effective combination AMP formulations are discussed.

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Metadata

Authors
Thapa, R. K., Diep, D. B., & Tønnesen, H. H.
Venue
Acta Biomaterialia
Publisher
Elsevier BV
Published
2020-02
Volume
103
Pages
52-67
ISSN
1742-7061 (ISSN-L)
DOI
10.1016/j.actbio.2019.12.025
OpenAlex
W2996661070
Cited by
378
References
9
FWCI
22.91
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects. https://app.cochat.ai/papers/10.1016/j.actbio.2019.12.025
The paper
Thapa, R. K., Diep, D. B., & Tønnesen, H. H. (2020). Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2019.12.025

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.