The DOI matches its Crossref record; 195 of the 195 references it cites were found in a registry or an index.
Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies
Open accessAbstract
Macrophages are a highly heterogeneous and plastic population of cells that are crucial for tissue repair and regeneration. This has made macrophages a particularly attractive target for biomaterial-directed regenerative medicine strategies. However, macrophages also contribute to adverse inflammatory and fibrotic responses to implanted biomaterials, typically related to the foreign body response (FBR). The traditional model in the field asserts that the M2 macrophage phenotype is pro-regenerative and associated with positive wound healing outcomes, whereas the M1 phenotype is pro-inflammatory and associated with pathogenesis. However, recent studies indicate that both M1 and M2 macrophages play different, but equally vital, roles in promoting tissue repair. Furthermore, recent technological developments such as single-cell RNA sequencing have allowed for unprecedented insights into the heterogeneity within the myeloid compartment, related to activation state, niche, and ontogenetic origin. A better understanding of the phenotypic and functional characteristics of macrophages critical to tissue repair and FBR processes will allow for rational design of biomaterials to promote biomaterial-tissue integration and regeneration. In this review, we discuss the role of temporal and ontogenetic macrophage heterogeneity on tissue repair processes and the FBR and the potential implications for biomaterial-directed regenerative medicine applications.
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Cites
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Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing
Mao, J., Chen, L., Cai, Z., Qian, S., Liu, Z., Zhao, B., Zhang, Y., Sun, X., & Cui, W. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202111003 · Cited by 253
Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction
Noskovicova, N., Hinz, B., & Pakshir, P. (2021) · Cells · doi:10.3390/cells10071794 · Cited by 184
Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity
Kyriakides, T. R., Kim, H.-J., Zheng, C., Harkins, L., Tao, W., & Deschenes, E. (2022) · Biomedical Materials · doi:10.1088/1748-605x/ac5574 · Cited by 106
The immunomodulatory effects of RNA-based biomaterials on bone regeneration
Wang, C.-Y., Qin, Z.-X., Wei, Y., Hao, J.-X., Zhu, Y.-F., Zhao, F., Jiao, K., Ehrlich, H., Tay, F. R., & Niu, L.-N. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.03.031 · Cited by 28
Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review
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“These methods detect rare and transitional subpopulations and, across diverse contexts including bioscaffolds, reveal that macrophage (and other immune cell types) phenotypes during healing form a rainbow or broad continuum [41–43].”
Influential
Metadata
- Authors
- Martin, K. E., & García, A. J.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 133
- Pages
- 4-16
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W3146582890
- Cited by
- 367
- References
- 195
- FWCI
- 23.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Martin, K. E., & García, A. J. (2021). Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2021.03.038
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