The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing
Abstract
The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications. In this work, a series of self-healing, adhesive and antibacterial hydrogels based on gelatin methacrylate (GelMA), adenine acrylate (AA), and CuCl2 were designed through covalent bonding, coordination complexation of Cu2+ and carboxyl groups and hydrogen bonding to promote diabetic wound healing. These hydrogels exhibit efficient self-healing properties, remarkable fatigue resistance, and good adhesive properties due to the hydrogen bond and the metal-ligand coordination provided by the Cu2+ and the carboxyl group. The GelMA/AA/Cu1.0 hydrogel (containing 1.0 mg/mL Cu2+) with well-balanced biocompatibility and antibacterial properties exhibited efficient hemostatic performance in a mouse liver trauma model and significantly promoted the healing process in a full-thickness skin diabetic wound model. The immunohistochemistry results showed that the GelMA/AA/Cu1.0 hydrogel can promote regular epithelialization and collagen deposition when compared to the TegadermTM Film, GelMA hydrogel, and GelMA/AA/Cu0 hydrogel. The immunofluorescence results confirmed that the GelMA/AA/Cu1.0 hydrogel can reduce the expression of proinflammatory factors and promote angiogenesis. In conclusion, the GelMA/AA/Cu hydrogel is an effective wound dressing to promote the healing process of diabetic skin wounds. STATEMENT OF SIGNIFICANCE: Diabetic wounds exhibit an extremely high risk of bacterial infection and poor angiogenesis in a high-sugar environment, hindering their healing process. Hydrogel wound dressings are a promising wound care material that need to have stable and long-lasting adhesive properties, avoid shedding, provide lasting protection to wounds, antibacterial properties and promote angiogenesis. In this study, a series of self-healing, adhesive, and antibacterial hydrogels based on gelatin methacrylate (GelMA), acrylated adenine (AA), and CuCl2 were designed and synthesized via free radical polymerization, hydrogen bond, and ionic bond to promote diabetic wound healing. Overall, GelMA/AA/Cu hydrogels are promising materials to promote diabetic wound healing.
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Cites
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Functional and bioactive properties of collagen and gelatin from alternative sources: A review
Gómez-Guillén, M. C., Giménez, B., López-Caballero, M. E., & Montero, M. P. (2011) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2011.02.007 · Cited by 2,052
Zhao, X., Wu, H., Guo, B., Dong, R., Qiu, Y., & Ma, P. X. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.011 · Cited by 1,971
Self-citationPrevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013
Wang, L., Gao, P., Zhang, M., Huang, Z., Zhang, D., Deng, Q., Li, Y., Zhao, Z., Qin, X., Jin, D., et al. (2017) · JAMA · doi:10.1001/jama.2017.7596 · Cited by 1,844
Qu, J., Zhao, X., Liang, Y., Zhang, T., Ma, P. X., & Guo, B. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.044 · Cited by 1,809
Self-citationLi, S., Dong, S., Xu, W., Tu, S., Yan, L., Zhao, C., Ding, J., & Chen, X. (2018) · Advanced Science · doi:10.1002/advs.201700527 · Cited by 1,145
Haemostatic materials for wound healing applications
Guo, B., Dong, R., Liang, Y., & Li, M. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-021-00323-z · Cited by 992
Self-citationSmart wound dressings for wound healing
Dong, R., & Guo, B. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101290 · Cited by 959
Self-citationUpdate on management of diabetic foot ulcers
Everett, E., & Mathioudakis, N. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13569 · Cited by 913
Liang, Y., Li, M., Yang, Y., Qiao, L., Xu, H., & Guo, B. (2022) · ACS Nano · doi:10.1021/acsnano.1c11040 · Cited by 876
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Anti‐inflammatory hydrogel dressings and skin wound healing
Huang, C., Dong, L., Zhao, B., Lu, Y., Huang, S., Yuan, Z., Luo, G., Xu, Y., & Qian, W. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1094 · Cited by 445
Liang, Y., Xu, H., Li, Z., Zhangji, A., & Guo, B. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00928-z · Cited by 313
Self-citationEmerging materials for hemostasis
Li, X.-F., Lu, P., Jia, H.-R., Li, G., Zhu, B., Wang, X., & Wu, F.-G. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214823 · Cited by 164
Chitosan and hyaluronic-based hydrogels could promote the infected wound healing
Bai, Q., Gao, Q., Hu, F., Zheng, C., Chen, W., Sun, N., Liu, J., Zhang, Y., Wu, X., & Lu, T. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123271 · Cited by 125
Zhang, H., Bai, J., Chen, X., Wang, L., Peng, W., Zhao, Y., Weng, J., Zhi, W., Wang, J., Zhang, K., et al. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae105 · Cited by 23
Metadata
- Authors
- Chen, J., He, J., Yang, Y., Qiao, L., Hu, J., Zhang, J., & Guo, B.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 146
- Pages
- 119-130
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W4224440853
- Cited by
- 359
- References
- 76
- FWCI
- 28.42
- Type
- journal article
- Language
- en
- Open access
- closed
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