Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429 · see citing works

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456 · see citing works

Cellular uptake of the tat protein from human immunodeficiency virus

Frankel, A. D., & Pabo, C. O. (1988) · Cell · doi:10.1016/0092-8674(88)90263-2 · Cited by 2,782 · see citing works

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

Schwarze, S. R., Ho, A. L., Vocero-Akbani, A. M., & Dowdy, S. F. (1999) · Science · doi:10.1126/science.285.5433.1569 · Cited by 2,418 · see citing works

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

Vivès, É., Brodin, P. M., & Lebleu, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.16010 · Cited by 2,377 · see citing works

The third helix of the Antennapedia homeodomain translocates through biological membranes.

Derossi, D., Joliot, A., Chassaing, G., & Prochiantz, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34080-2 · Cited by 2,034 · see citing works

Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells

Lewin, M., Carlesso, N., Tung, C., Tang, X. S., Cory, D. G., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716 · see citing works

Arginine-rich Peptides

Futaki, S., Suzuki, T. W., Ohashi, W., Yagami, T., Tanaka, S., Ueda, K., & Sugiura, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007540200 · Cited by 1,667 · see citing works

Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis

Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647 · see citing works

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cellsPreprint

Paddison, P. J., Caudy, A. A., Bernstein, E., Hannon, G. J., & Conklin, D. S. (2002) · Genes & Development · doi:10.1101/gad.981002 · Cited by 1,554 · see citing works

Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

Green, M., & Loewenstein, P. M. (1988) · Cell · doi:10.1016/0092-8674(88)90262-0 · Cited by 1,551 · see citing works

Transvascular delivery of small interfering RNA to the central nervous system

Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature · doi:10.1038/nature05901 · Cited by 1,246 · see citing works

Interfering with disease: a progress report on siRNA-based therapeutics

de Fougerolles, A., Vornlocher, H., Maraganore, J. M., & Lieberman, J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2310 · Cited by 1,202 · see citing works

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

Caplen, N. J., Parrish, S., Imani, F., Fire, A. Z., & Morgan, R. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171251798 · Cited by 1,042 · see citing works

A peptide carrier for the delivery of biologically active proteins into mammalian cells

Morris, M. C., Depollier, J., Méry, J., Heitz, F., & Divita, G. (2001) · Nature Biotechnology · doi:10.1038/nbt1201-1173 · Cited by 1,019 · see citing works

Intercellular Trafficking and Protein Delivery by a Herpesvirus Structural Protein

Elliott, G., & O’Hare, P. (1997) · Cell · doi:10.1016/s0092-8674(00)81843-7 · Cited by 975 · see citing works

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

Nagahara, H., Vocero-Akbani, A. M., Snyder, E. L., Ho, A. L., Latham, D. G., Lissy, N. A., Becker‐Hapak, M., Ezhevsky, S. A., & Dowdy, S. F. (1998) · Nature Medicine · doi:10.1038/4042 · Cited by 928 · see citing works

High-Efficiency Intracellular Magnetic Labeling with Novel Superparamagnetic-Tat Peptide Conjugates

Josephson, L., Tung, C., Moore, A. V., & Weissleder, R. (1999) · Bioconjugate Chemistry · doi:10.1021/bc980125h · Cited by 882 · see citing works

Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin

Oubridge, C., Ito, N., Evans, P. R., Teo, C.-H., & Nagai, K. (1994) · Nature · doi:10.1038/372432a0 · Cited by 832 · see citing works

Cell-penetrating peptides: mechanism and kinetics of cargo delivery

Zorko, M., & Langel, Ü. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.10.010 · Cited by 799 · see citing works

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

Torchilin, V. P., Rammohan, R., Weissig, V., & Levchenko, T. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151247498 · Cited by 777 · see citing works

Cellular Uptake of Arginine-Rich Peptides: Roles for Macropinocytosis and Actin Rearrangement

Nakase, I., Niwa, M., Takeuchi, T., Sonomura, K., Kawabata, N., Koike, Y., Takehashi, M., Tanaka, S., Ueda, K., Simpson, J. C., et al. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.08.010 · Cited by 753 · see citing works

Cell penetration by transportan

Pooga, M., Hällbrink, M., Zorko, M., & Langel, U. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.1.67 · Cited by 680 · see citing works

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

Rothbard, J. B., Garlington, S., Lin, Q., Kirschberg, T. A., Kreider, E., McGrane, P. L., Wender, P. A., & Khavari, P. A. (2000) · Nature Medicine · doi:10.1038/81359 · Cited by 632 · see citing works

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

Kumar, P., Ban, H., Kim, S. S., Wu, H., Pearson, T., Greiner, D. L., Laouar, A., Yao, J., Haridas, V., Habiro, K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.034 · Cited by 573 · see citing works

A new peptide vector for efficient delivery of oligonucleotides into mammalian cells

Morris, M. C. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.14.2730 · Cited by 535 · see citing works

Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

Simeoni, F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg385 · Cited by 481 · see citing works

Delivery of bioactive molecules into the cell: the Trojan horse approach

Dietz, G. P. H., & Bähr, M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.03.005 · Cited by 469 · see citing works

Photochemical internalization: a novel technology for delivery of macromolecules into cytosol.

Berg, K., Selbo, P. K., Prasmickaite, L., Tjelle, T. E., Sandvig, K., Moan, J. E., Gaudernack, G., Fodstad, Ø., Kjølsrud, S., Anholt, H., et al. (1999) · PubMed · Cited by 423 · see citing works

Cationic lipids and polymers mediated vectors for delivery of siRNA

Zhang, S., Zhao, B., Jiang, H., Wang, B., & Ma, B. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.07.016 · Cited by 421 · see citing works

Cargo‐dependent mode of uptake and bioavailability of TAT‐containing proteins and peptides in living cells

Lättig-Tünnemann, G., Martin, R. M., Haupt, S., Patsch, C., Edenhofer, F., & Cardoso, M. C. (2006) · The FASEB Journal · doi:10.1096/fj.05-5523com · Cited by 403 · see citing works

High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression

Khalil, I. A., Kogure, K., Futaki, S., & Harashima, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503202200 · Cited by 391 · see citing works

Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells

朴, 南., & Eccles, M. R. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01505-9 · Cited by 390 · see citing works

Visualizing a Correlation between siRNA Localization, Cellular Uptake, and RNAi in Living Cells

Chiu, Y., Ali, A., Chu, C., Cao, H., & Rana, T. M. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.06.006 · Cited by 381 · see citing works

siRNA-based approaches in cancer therapy

Devi, G. R. (2006) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700931 · Cited by 354 · see citing works

Lung Delivery Studies Using siRNA Conjugated to TAT(48−60) and Penetratin Reveal Peptide Induced Reduction in Gene Expression and Induction of Innate Immunity

Moschos, S. A., Jones, S. W., Perry, M. M., Williams, A. E., Erjefalt, J. S., Turner, J. J., Barnes, P. J., Sproat, B. S., Gait, M. J., & Lindsay, M. A. (2007) · Bioconjugate Chemistry · doi:10.1021/bc070077d · Cited by 350 · see citing works

A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

Crombez, L., Aldrian, G., Konate, K., Nguyen, Q., McMaster, G., Brasseur, R., Heitz, F., & Divita, G. (2008) · Molecular Therapy · doi:10.1038/mt.2008.215 · Cited by 346 · see citing works

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y., & Hori, M. (2004) · Nature Medicine · doi:10.1038/nm1111 · Cited by 337 · see citing works

Delivery of short interfering RNA using endosomolytic cell‐penetrating peptides

Lundberg, P., Andaloussi, S. E., Sütlü, T., Johansson, H. J., & Langel, Ü. (2007) · The FASEB Journal · doi:10.1096/fj.06-6502com · Cited by 322 · see citing works

Peptide-guided gene delivery

Martin, M. E., & Rice, K. G. (2007) · The AAPS Journal · doi:10.1208/aapsj0901003 · Cited by 321 · see citing works

Macropinocytosis: searching for an endocytic identity and role in the uptake of cell penetrating peptides

Jones, A. T. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00062.x · Cited by 315 · see citing works

Cell surface adherence and endocytosis of protein transduction domains

Lundberg, M., Wikström, S., & Johansson, M. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00135-7 · Cited by 306 · see citing works

Gene therapy progress and prospects: synthetic polymer-based systems

Schaffert, D., & Wagner, E. (2008) · Gene Therapy · doi:10.1038/gt.2008.105 · Cited by 277 · see citing works

Break on through to the Other Side—Biophysics and Cell Biology Shed Light on Cell‐Penetrating Peptides

Fischer, R., Fotin‐Mleczek, M., Hufnagel, H., & Brock, R. E. (2005) · ChemBioChem · doi:10.1002/cbic.200500044 · Cited by 266 · see citing works

Self-Assembled Quantum Dot−Peptide Bioconjugates for Selective Intracellular Delivery

Delehanty, J. B., Medintz, I. L., Pons, T., Brunel, F. M., Dawson, P. E., & Mattoussi, H. M. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060044i · Cited by 264 · see citing works

Effects of cargo molecules on the cellular uptake of arginine-rich cell-penetrating peptides

Maiolo, J. R., Ferrer, M., & Ottinger, E. A. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.04.010 · Cited by 251 · see citing works

Gene delivery by cationic lipid vectors: overcoming cellular barriers

Zuhorn, I. S., Engberts, J. B. F. N., & Hoekstra, D. (2006) · European Biophysics Journal · doi:10.1007/s00249-006-0092-4 · Cited by 225 · see citing works

Photochemical internalisation in drug and gene delivery

Høgset, A. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.08.016 · Cited by 223 · see citing works

Highly Efficient Small Interfering RNA Delivery to Primary Mammalian Neurons Induces MicroRNA-Like Effects before mRNA Degradation

Davidson, T. J., Harel, S., Arboleda, V. A., Prunell, G., Shelanski, M. L., Greene, L. A., & Troy, C. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3643-04.2004 · Cited by 215 · see citing works

Insight into the Mechanism of Internalization of the Cell-Penetrating Carrier Peptide Pep-1 through Conformational Analysis

Deshayes, S., Heitz, A., Morris, M. C., Charnet, P., Divita, G., & Heitz, F. (2004) · Biochemistry · doi:10.1021/bi035682s · Cited by 198 · see citing works

Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect

Veldhoen, S., Laufer, S. D., Trampe, A., & Restle, T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl941 · Cited by 188 · see citing works

Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy

Deshayes, S., Morris, M. C., Heitz, F., & Divita, G. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.09.005 · Cited by 185 · see citing works

Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides

Meade, B. R., & Dowdy, S. F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.10.004 · Cited by 174 · see citing works

Cell-penetrating Peptide for Enhanced Delivery of Nucleic Acids and Drugs to Ocular Tissues Including Retina and Cornea

Johnson, L. N., Cashman, S. M., & Kumar‐Singh, R. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300324 · Cited by 162 · see citing works

Efficiency of Protein Transduction Is Cell Type-dependent and Is Enhanced by Dextran Sulfate

Mai, J. C., Shen, H., Watkins, S. C., Cheng, T., & Robbins, P. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204202200 · Cited by 156 · see citing works

RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA

Turner, J. J., Jones, S. W., Fabani, M. M., Ivanova, G. D., Arzumanov, A. A., & Gait, M. J. (2006) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2006.10.003 · Cited by 148 · see citing works

Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells.

Harada, H., Hiraoka, M., & Kizaka‐Kondoh, S. (2002) · PubMed · Cited by 146 · see citing works

Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates

Abes, S., Williams, D., Prévôt, P., Thierry, A. R., Gait, M. J., & Lebleu, B. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.10.026 · Cited by 143 · see citing works

The NH2 Terminus of Influenza Virus Hemagglutinin-2 Subunit Peptides Enhances the Antitumor Potency of Polyarginine-mediated p53 Protein Transduction

Michiue, H., Tomizawa, K., Wei, F., Matsushita, M., Lü, Y.-F., Ichikawa, T., Tamiya, T., Date, I., & Matsui, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412430200 · Cited by 132 · see citing works

Multicolor Coding of Cells with Cationic Peptide Coated Quantum Dots

Lagerholm, B. C., Wang, M., Ernst, L. A., Ly, D. H., Liu, H., Bruchez, M. P., & Waggoner, A. S. (2004) · Nano Letters · doi:10.1021/nl049295v · Cited by 130 · see citing works

On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids

Deshayes, S., Gerbal‐Chaloin, S., Morris, M. C., Aldrian, G., Charnet, P., Divita, G., & Heitz, F. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.09.010 · Cited by 120 · see citing works

Interaction of N-terminal domain of U1A protein with an RNA stem/loop

Hall, K. B., & Stump, W. T. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.16.4283 · Cited by 111 · see citing works

A novel TAT–Mitochondrial signal sequence fusion protein is processed, stays in mitochondria, and crosses the placenta

Gaizo, V. D., & Payne, R. M. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00130-8 · Cited by 105 · see citing works

Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA

Oliveira, S., Fretz, M. M., Høgset, A., Storm, G., & Schiffelers, R. M. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.01.013 · Cited by 104 · see citing works

Synthesis of doxorubicin–peptide conjugate with multidrug resistant tumor cell killing activity

Liang, J. F., & Yang, V. C.-M. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.07.087 · Cited by 104 · see citing works

Cellular siRNA Delivery Mediated by a Cell-Permeant RNA-Binding Protein and Photoinduced RNA Interference

Endoh, T., Sisido, M., & Ohtsuki, T. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800020n · Cited by 80 · see citing works

An intracellular delivery method for siRNA by an arginine-rich peptide

Wang, Y., Hou, Y., & Lee, H. (2007) · Journal of Biochemical and Biophysical Methods · doi:10.1016/j.jbbm.2007.01.010 · Cited by 70 · see citing works

Photo‐acceleration of protein release from endosome in the protein transduction system

Matsushita, M., Noguchi, H., Lü, Y.-F., Tomizawa, K., Michiue, H., Li, S., Hirose, K., Bonner‐Weir, S., & Matsui, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.033 · Cited by 68 · see citing works

Specific Redistribution of Cell-Penetrating Peptides from Endosomes to the Cytoplasm and Nucleus upon Laser Illumination

Maiolo, J. R., Ottinger, E. A., & Ferrer, M. (2004) · Journal of the American Chemical Society · doi:10.1021/ja044867z · Cited by 67 · see citing works

Efficient Intracellular Delivery of GFP by Homeodomains of Drosophila Fushi-tarazu and Engrailed Proteins

Han, K., Jeon, M.-J., Kim, K.-A., Park, J., & Choi, S.-Y. (2000) · Molecules and Cells · doi:10.1007/s10059-000-0728-7 · Cited by 62 · see citing works

Intracellular delivery of antibodies using TAT fusion protein A

Mie, M., Takahashi, F., Funabashi, H., Yanagida, Y., Aizawa, M., & Kobatake, E. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.071 · Cited by 61 · see citing works

A TAT–streptavidin fusion protein directs uptake of biotinylated cargo into mammalian cells

Albarran, B., To, R., & Stayton, P. S. (2005) · Protein Engineering Design and Selection · doi:10.1093/protein/gzi014 · Cited by 54 · see citing works

Quantitative Assessment of the Cell Penetrating Properties of RI-Tat-9: Evidence for a Cell Type-Specific Barrier at the Plasma Membrane of Epithelial Cells

Zhang, X., Wan, L., Pooyan, S., Su, Y., Gardner, C. R., Leibowitz, M. J., Stein, S., & Sinko, P. J. (2004) · Molecular Pharmaceutics · doi:10.1021/mp034014y · Cited by 31 · see citing works

On the Mechanism of Oxidative Cleavage of Aryl-Alkyl Ethers by Liver Microsomes

Renson, J., Weissbach, H., & Udenfriend, S. (1965) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14738-x · Cited by 28 · see citing works

Comparison of Protein Transduction Domains in Mediating Cell Delivery of a Secreted CRE Protein

Shaw, P. A., Catchpole, I. R., Goddard, C. A., & Colledge, W. H. (2008) · Biochemistry · doi:10.1021/bi701542p · Cited by 15 · see citing works

The evolution of commercial drug delivery technologies

Vargason, A. M., Anselmo, A. C., & Mitragotri, S. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00698-w · Cited by 1,361 · see citing works

Smart nanoparticles for cancer therapy

Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works

Delivery of siRNA Therapeutics: Barriers and Carriers

Wang, J., Lu, Z., Wientjes, M. G., & Au, J. L. ‐. (2010) · The AAPS Journal · doi:10.1208/s12248-010-9210-4 · Cited by 804 · see citing works

Breaking down the barriers: siRNA delivery and endosome escape

Domińska, M., & Dykxhoorn, D. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.066399 · Cited by 632 · see citing works

Molecular Mechanisms and Biological Functions of siRNA

Dana, H., Chalbatani, G. M., Mahmoodzadeh, H., Gharagouzloo, E., Karimloo, R., Rezaiean, O., Moradzadeh, A., Mazraeh, A., Marmari, V., Rashno, M. M., et al. (2017) · International Journal of Biomedical Science · doi:10.59566/ijbs.2017.13048 · Cited by 505 · see citing works

Silk-based delivery systems of bioactive molecules

Numata, K., & Kaplan, D. L. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.009 · Cited by 387 · see citing works

Immunomodulatory Nanosystems

Feng, X.-R., Xu, W.-G., Li, Z., Song, W.-T., Ding, J.-X., & Chen, X.-S. (2019) · Advancement of science · doi:10.1002/advs.201900101 · Cited by 294 · see citing works

Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery

Jin, E., Zhang, B., Sun, X., Zhou, Z., Ma, X., Sun, Q., Tang, J., Shen, Y., Kirk, E. V., Murdoch, W. J., et al. (2012) · Journal of the American Chemical Society · doi:10.1021/ja311180x · Cited by 330 · see citing works

Gold Nanoparticles Capped with Polyethyleneimine for Enhanced siRNA Delivery

Song, W., Du, J., Sun, T., Zhang, P., & Wang, J. (2009) · Small · doi:10.1002/smll.200901513 · Cited by 298 · see citing works

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Trabulo, S. M. D., Cardoso, A. L., Mano, M., & de Lima, M. C. P. (2010) · Pharmaceuticals · doi:10.3390/ph3040961 · Cited by 290 · see citing works

Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies

Habault, J., & Poyet, J. (2019) · Molecules · doi:10.3390/molecules24050927 · Cited by 282 · see citing works

Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles

Kanasty, R. L., Whitehead, K. A., Vegas, A. J., & Anderson, D. G. (2012) · Molecular Therapy · doi:10.1038/mt.2011.294 · Cited by 281 · see citing works

Cell penetrating peptides: Efficient vectors for delivery of nanoparticles, nanocarriers, therapeutic and diagnostic molecules

Farkhani, S. M., Valizadeh, A., Karami, H., Mohammadi, S., Sohrabi, N., & Badrzadeh, F. (2014) · Peptides · doi:10.1016/j.peptides.2014.04.015 · Cited by 273 · see citing works

Different strategies to overcome multidrug resistance in cancer

Manju, S., & Gong, S. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.06.004 · Cited by 250 · see citing works

Overcoming Endosomal Barrier by Amphotericin B-Loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery

Yu, H., Zou, Y., Wang, Y., Huang, X., Huang, G., Sumer, B. D., Boothman, D. A., & Gao, J. (2011) · ACS Nano · doi:10.1021/nn203503h · Cited by 237 · see citing works

Cell entry of cell penetrating peptides: tales of tails wagging dogs

Jones, A. T., & Sayers, E. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.003 · Cited by 236 · see citing works

Cell-penetrating peptides: strategies for anticancer treatment

Raucher, D., & Ryu, J. S. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.06.005 · Cited by 234 · see citing works

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

Chalbatani, G. M., Dana, H., Gharagouzloo, E., Grijalvo, S., Eritja, R., Logsdon, C. D., Memari, F., Miri, S. R., Rad, M. R., & Marmari, V. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s200253 · Cited by 238 · see citing works

Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

Qiu, C., Xia, F., Zhang, J., Shi, Q., Meng, Y., Wang, C., Pang, H., Gu, L., Xu, C., Guo, Q., et al. (2023) · Research · doi:10.34133/research.0148 · Cited by 229 · see citing works

Subcellular Fate and Off-Target Effects of siRNA, shRNA, and miRNA

Singh, S. P., Narang, A. S., & Mahato, R. I. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0608-1 · Cited by 221 · see citing works

Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery

McCarthy, H. O., McCaffrey, J., McCrudden, C. M., Zholobenko, A., Ali, A. A., McBride, J. W., Massey, A. S., Pentlavalli, S., Chen, K.-H., Cole, G., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.048 · Cited by 216 · see citing works

Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery

Margus, H., Padari, K., & Pooga, M. (2012) · Molecular Therapy · doi:10.1038/mt.2011.284 · Cited by 215 · see citing works

Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges

Zhou, J., Shum, K., Burnett, J., & Rossi, J. J. (2013) · Pharmaceuticals · doi:10.3390/ph6010085 · Cited by 206 · see citing works

Functional peptides for siRNA delivery

Tai, W., & Gao, X. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.08.004 · Cited by 198 · see citing works

Peptides for cell-selective drug delivery

Svensen, N., Walton, J. G. A., & Bradley, M. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.02.002 · Cited by 196 · see citing works

Cellular Uptake and Intracellular Trafficking of Antisense and siRNA Oligonucleotides

Juliano, R. L., Ming, X., & Nakagawa, O. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200377d · Cited by 193 · see citing works

Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges

Komin, A., Russell, L. M., Hristova, K. A., & Searson, P. C. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.002 · Cited by 189 · see citing works

Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy

Guo, X., Xiao, W., Chen, Z., Zhang, X., Yang, G., & Zhou, S. (2019) · Progress in Materials Science · doi:10.1016/j.pmatsci.2019.100599 · Cited by 171 · see citing works

Fibronectin: How Its Aberrant Expression in Tumors May Improve Therapeutic Targeting

Wang, J. P., & Hielscher, A. C. (2017) · Journal of Cancer · doi:10.7150/jca.16901 · Cited by 167 · see citing works

Lipid peroxidation causes endosomal antigen release for cross-presentation

Dingjan, I., Verboogen, D. R. J., Paardekooper, L. M., Revelo, N. H., Sittig, S. P., Visser, L. J., von Mollard, G. F., Henriet, S., Figdor, C. G., ter Beest, M., et al. (2016) · Scientific Reports · doi:10.1038/srep22064 · Cited by 153 · see citing works

Progress and perspectives in developing polymeric vectors for in vitro gene delivery

Yue, Y., & Wu, C. C. (2012) · Biomaterials Science · doi:10.1039/c2bm00030j · Cited by 152 · see citing works

siRNA based drug design, quality, delivery and clinical translation

Subhan, M. A., & Torchilin, V. P. (2020) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2020.102239 · Cited by 152 · see citing works

Cell‐penetrating Peptides as a Novel Transdermal Drug Delivery System

Nasrollahi, S. A., Taghibiglou, C., Azizi, E., & Farboud, E. S. (2012) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12008 · Cited by 150 · see citing works

Emerging nanomaterials for targeting subcellular organelles

Huang, J. G., Leshuk, T. M. C., & Gu, F. (2011) · Nano Today · doi:10.1016/j.nantod.2011.08.002 · Cited by 147 · see citing works

Cell-penetrating peptides for the delivery of nucleic acids

Lehto, T., Kurrikoff, K., & Langel, Ü. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.689285 · Cited by 141 · see citing works

Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine–hyaluronic acid conjugate

Park, K., Lee, M., Kim, K. S., & Hahn, S. K. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.018 · Cited by 133 · see citing works

Supramolecular assemblies in functional siRNA delivery: Where do we stand?

Aliabadi, H. M., Landry, B. K., Sun, C., Tang, T., & Uludağ, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.079 · Cited by 133 · see citing works

Charge-reversal nanocarriers: An emerging paradigm for smart cancer nanomedicine

Zhang, M., Chen, X., Li, C., & Shen, X. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.024 · Cited by 126 · see citing works

Cell Penetrating Peptides in the Delivery of Biopharmaceuticals

Munyendo, W. L. L., Lv, H., Benza-Ingoula, H., Baraza, L. D., & Zhou, J. (2012) · Biomolecules · doi:10.3390/biom2020187 · Cited by 124 · see citing works

Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems

Liang, W., & Lam, J. K. W. (2012) · InTech eBooks · doi:10.5772/46006 · Cited by 121 · see citing works

Circulating microRNAs in Medicine

Pozniak, T., Shcharbin, D., & Bryszewska, M. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073996 · Cited by 121 · see citing works

Gene delivery to tumor cells by cationic polymeric nanovectors coupled to folic acid and the cell-penetrating peptide octaarginine

Jiang, Q., Lai, L., Shen, J. M., Wang, Q., Xu, F., & Tang, G. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.06.015 · Cited by 118 · see citing works

Cell penetrating peptide-modified poly(lactic-co-glycolic acid) nanoparticles with enhanced cell internalization

Steinbach-Rankins, J. M., Seo, Y.-E., & Saltzman, W. M. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.11.029 · Cited by 109 · see citing works

How successful is nuclear targeting by nanocarriers?

Tammam, S. N., Azzazy, H. M. E.-S., & Lamprecht, A. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.03.022 · Cited by 108 · see citing works

Current Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAs

Johannes, L., & Lucchino, M. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2017.0716 · Cited by 108 · see citing works

Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?

Guo, J., Bourré, L., Soden, D. M., O’Sullivan, G. C., & O’Driscoll, C. M. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.03.003 · Cited by 105 · see citing works

Versatile RNA Interference Nanoplatform for Systemic Delivery of RNAs

Choi, K. Y., Silvestre, O. F., Huang, X., Min, K. H., Howard, G. P., Hida, N., Jin, A. J., Carvajal, N., Lee, S. W., Hong, J.-I., et al. (2014) · ACS Nano · doi:10.1021/nn500085k · Cited by 104 · see citing works

Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)‐Functionalized, Self‐Assembled Nanoconjugate

Liu, G., Choi, K. Y., Bhirde, A. A., Swierczewska, M., Yin, J. J., Lee, S. W., Park, J. H., Hong, J. I., Xie, J., Niu, G., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201105565 · Cited by 102 · see citing works

Mechanisms of nanoparticle-mediated siRNA transfection by melittin-derived peptides

Hou, K. K., Pan, H., Ratner, L., Schlesinger, P. H., & Wickline, S. A. (2013) · ACS Nano · doi:10.1021/nn403311c · Cited by 95 · see citing works

Tumor‐Triggered Disassembly of a Multiple‐Agent‐Therapy Probe for Efficient Cellular Internalization

Yang, J., Dai, J., Wang, Q., Cheng, Y., Guo, J., Zhao, Z., Hong, Y., Lou, X., & Xia, F. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202009196 · Cited by 95 · see citing works

Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group

Petrova, N. S., Chernikov, I. V., Meschaninova, M. I., Dovydenko, I. S., Venyaminova, A. G., Аркадьевна, З. М., Vlassov, V. V., & Chernolovskaya, E. L. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1002 · Cited by 96 · see citing works

Development of RNAi technology for targeted therapy — A track of siRNA based agents to RNAi therapeutics

Zhou, Y., Zhang, C., & Liang, W. P. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.044 · Cited by 91 · see citing works

RNAi Therapeutic Platforms for Lung Diseases

Fujita, Y., Takeshita, F., Kuwano, K., & Ochiya, T. (2013) · Pharmaceuticals · doi:10.3390/ph6020223 · Cited by 92 · see citing works

Melittin derived peptides for nanoparticle based siRNA transfection

Hou, K. K., Pan, H., Lanza, G. M., & Wickline, S. A. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.037 · Cited by 91 · see citing works

Therapeutic Potential of cell-penetrating Peptides

Vasconcelos, D., Pärn, K., & Langel, Ü. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.22 · Cited by 90 · see citing works

Cell biology meets biophysics to unveil the different mechanisms of penetratin internalization in cells

Alves, I. D., Jiao, C.-Y., Aubry, S., Aussedat, B., Burlina, F., Chassaing, G., & Sagan, S. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.02.009 · Cited by 89 · see citing works

Efficient Cytosolic Delivery of siRNA Using HDL‐Mimicking Nanoparticles

Yang, M., Jin, H., Chen, J., Ding, L., Ng, K. K., Lin, Q., Lovell, J. F., Zhang, Z., & Zheng, G. (2011) · Small · doi:10.1002/smll.201001589 · Cited by 89 · see citing works

Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery

Fields, R. J., Cheng, C. J., Quijano, E., Weller, C. E., Kristofik, N. J., Duong, N. T., Hoimes, C. J., Egan, M. E., & Saltzman, W. M. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.09.020 · Cited by 88 · see citing works

A quantitative comparison of cytosolic delivery via different protein uptake systems

Verdurmen, W. P. R., Mazlami, M., & Plückthun, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-13469-y · Cited by 87 · see citing works

A role for peptides in overcoming endosomal entrapment in siRNA delivery — A focus on melittin

Hou, K. K., Pan, H., Schlesinger, P. H., & Wickline, S. A. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.05.005 · Cited by 86 · see citing works

Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics

Hyeon, L. S., Kang, Y. Y., Jang, H.-E., & Mok, H. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.009 · Cited by 84 · see citing works

Cell penetrating peptide conjugated bioreducible polymer for siRNA delivery

Nam, H. Y., Kim, J., Kim, S., Yockman, J. W., Kim, S. W., & Bull, D. A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.058 · Cited by 80 · see citing works

Design, Synthesis and Characterization of a New Anionic Cell‐Penetrating Peptide: SAP(E)

Martín, I., Teixidò, M., & Giralt, E. (2011) · ChemBioChem · doi:10.1002/cbic.201000679 · Cited by 79 · see citing works

Virus-inspired nucleic acid delivery system: Linking virus and viral mimicry

Ni, R., Zhou, J., Hossain, N., & Chau, Y. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.07.005 · Cited by 78 · see citing works

Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform

Sharei, A., Poceviciute, R., Jackson, E., Cho, N., Mao, S., Hartoularos, G. C., Jang, D. Y., Jhunjhunwala, S., Eyerman, A. T., Schoettle, T., et al. (2014) · Integrative Biology · doi:10.1039/c3ib40215k · Cited by 74 · see citing works

Design of polymers for siRNA delivery: Recent progress and challenges

Wang, H., Zhang, S., Lv, J., & Cheng, Y. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20200026 · Cited by 78 · see citing works

Synergistic effects of cell-penetrating peptide Tat and fusogenic peptide HA2-enhanced cellular internalization and gene transduction of organosilica nanoparticles

Ye, S., Tian, M.-M., Wang, T., Ren, L., Wang, D., Shen, L., & Shang, T. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.10.003 · Cited by 73 · see citing works

pH-Triggered, Macromolecule-Sized Poration of Lipid Bilayers by Synthetically Evolved Peptides

Wiedman, G. R., Kim, S. Y., Zapata-Mercado, E. A., Wimley, W. C., & Hristova, K. A. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b11447 · Cited by 72 · see citing works

Photoinduced RNA Interference

Matsushita‐Ishiodori, Y., & Ohtsuki, T. (2012) · Accounts of Chemical Research · doi:10.1021/ar200227n · Cited by 70 · see citing works

Highly Efficient and Safe Delivery of VEGF siRNA by Bioreducible Fluorinated Peptide Dendrimers for Cancer Therapy

Cai, X., Zhu, H., Zhang, Y., & Gu, Z. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b16689 · Cited by 70 · see citing works

Antimicrobial Peptides and Cell-Penetrating Peptides: Non-Antibiotic Membrane-Targeting Strategies Against Bacterial Infections

Huang, X., & Li, G. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s396566 · Cited by 66 · see citing works

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

Bartz, R., Fan, H., Zhang, J., Innocent, N., Cherrin, C., Beck, S. C., Pei, Y., Momose, A., Jadhav, V., Tellers, D. M., et al. (2011) · Biochemical Journal · doi:10.1042/bj20101021 · Cited by 63 · see citing works

Efficient siRNA delivery using novel siRNA-loaded Bubble liposomes and ultrasound

Endo‐Takahashi, Y., Negishi, Y., Kato, Y., Suzuki, R., Maruyama, K., & Aramaki, Y. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.11.023 · Cited by 62 · see citing works

Crosstalk between M2 macrophages and glioma stem cells

Nusblat, L. M., Carroll, M. J., & Roth, C. M. (2017) · Cellular Oncology · doi:10.1007/s13402-017-0337-5 · Cited by 62 · see citing works

Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies

Li, H., Tsui, T. Y., & Ma, W. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160819518 · Cited by 61 · see citing works

The optimization of polymalic acid peptide copolymers for endosomolytic drug delivery

Ding, H., Portilla‐Arias, J., Patil, R., Black, K. L., Ljubimova, J. Y., & Holler, E. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.073 · Cited by 59 · see citing works

Stepwise-Acid-Active Multifunctional Mesoporous Silica Nanoparticles for Tumor-Specific Nucleus-Targeted Drug Delivery

Li, Z., Liu, Y., Hu, J., Xu, Q., Liu, L., Jia, H.-Z., Chen, W., Lei, Q., Rong, L., & Zhang, X. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am503846p · Cited by 58 · see citing works

Delivery of siRNA Using Lipid Nanoparticles Modified with Cell Penetrating Peptide

Li, Y., Lee, R. J., Yu, K., Bi, Y., Qi, Y., Sun, Y., Li, Y., Xie, J., & Teng, L. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b09991 · Cited by 58 · see citing works

Rationale and Application of PEGylated Lipid-Based System for Advanced Target Delivery of siRNA

Ge, X., Chen, L., Zhao, B., & Yuan, W. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.598175 · Cited by 55 · see citing works

Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination

Lim, S., Koo, J., & Choi, J. (2016) · Immune Network · doi:10.4110/in.2016.16.1.33 · Cited by 54 · see citing works

Building Cell Selectivity into CPP-Mediated Strategies

Martín, I., Teixidò, M., & Giralt, E. (2010) · Pharmaceuticals · doi:10.3390/ph3051456 · Cited by 52 · see citing works

High-Yield Synthesis of Monomeric LMWP(CPP)-siRNA Covalent Conjugate for Effective Cytosolic Delivery of siRNA

Ye, J., Liu, E., Gong, J., Wang, J., Huang, Y., He, H., & Yang, V. C.-M. (2017) · Theranostics · doi:10.7150/thno.19863 · Cited by 53 · see citing works

Potential of cell-penetrating peptides (CPPs) in delivery of antiviral therapeutics and vaccines

Sadeghian, I., Heidari, R., Sadeghian, S., Raee, M. J., & Negahdaripour, M. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.106094 · Cited by 54 · see citing works

Peptide Vectors for Gene Delivery: From Single Peptides to Multifunctional Peptide Nanocarriers

de Raad, M., Teunissen, E. A., & Mastrobattista, E. (2014) · Nanomedicine · doi:10.2217/nnm.14.90 · Cited by 52 · see citing works

Targeted siRNA delivery using aptamer‐siRNA chimeras and aptamer‐conjugated nanoparticles

Sivakumar, P., Kim, S., Kang, H. C., & Shim, M. S. (2018) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1543 · Cited by 52 · see citing works

Endosomolytic Anionic Polymer for the Cytoplasmic Delivery of siRNAs in Localized In Vivo Applications

Khormaee, S., Choi, Y., Shen, M. J., Xu, B., Wu, H., Griffiths, G. L., Chen, R., Slater, N. K. H., & Park, J. K. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201201945 · Cited by 51 · see citing works

Peptide-Based and Polypeptide-Based Gene Delivery Systems

Chen, J., Guan, X., Hu, Y., Tian, H., & Chen, X. (2017) · Topics in Current Chemistry · doi:10.1007/s41061-017-0115-x · Cited by 50 · see citing works

A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

Li, W., Wang, D., Shi, X., Li, J., Ma, Y., Wang, Y., Li, T., Zhang, J., Zhao, R., Yu, Z., et al. (2018) · Materials Horizons · doi:10.1039/c8mh00392k · Cited by 50 · see citing works

The Fate of Nanocarriers As Nanomedicines In Vivo: Important Considerations and Biological Barriers to Overcome

Moros, M., Mitchell, S. G., Grazú, V., & de la Fuente, J. M. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320220003 · Cited by 49 · see citing works

Novel Protein Transduction Domain Mimics as Nonviral Delivery Vectors for siRNA Targeting NOTCH1 in Primary Human T cells

Tezgel, A. Ö., González‐Pérez, G., Telfer, J. C., Osborne, B. A., Minter, L. M., & Tew, G. N. (2012) · Molecular Therapy · doi:10.1038/mt.2012.209 · Cited by 47 · see citing works

Challenges in Neuroprotective Nanomedicine Development: Progress Towards Noninvasive Gene Therapy of Glaucoma

Alqawlaq, S., Huzil, J. T., Ivanova, M. V., & Földvári, M. (2012) · Nanomedicine · doi:10.2217/nnm.12.69 · Cited by 47 · see citing works

Attachment of Cell-Binding Ligands to Arginine-Rich Cell-Penetrating Peptides Enables Cytosolic Translocation of Complexed siRNA

Zeller, S., Choi, C. S., Uchil, P. D., Ban, H., Siefert, A. L., Fahmy, T. M., Mothes, W., Lee, S., & Kumar, P. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.11.009 · Cited by 45 · see citing works

Cell Penetrating Peptide-Based Redox-Sensitive Vaccine Delivery System for Subcutaneous Vaccination

Wang, K., Yang, Y., Xue, W., & Liu, Z. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00905 · Cited by 45 · see citing works

DNA-Interactive Properties of Crotamine, a Cell-Penetrating Polypeptide and a Potential Drug Carrier

Chen, P., Hayashi, M. A. F., Oliveira, E. B., & Karpel, R. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048913 · Cited by 44 · see citing works

Ligand targeting and peptide functionalized polymers as non-viral carriers for gene therapy

Muhammad, K., Zhao, J., Ullah, I., Guo, J., Ren, X., & Feng, Y. (2019) · Biomaterials Science · doi:10.1039/c9bm01112a · Cited by 44 · see citing works

Novel epithelial cell adhesion molecule antibody conjugated polyethyleneimine-capped gold nanoparticles for enhanced and targeted small interfering RNA delivery to retinoblastoma cells.

Mitra, M., Kandalam, M., Rangasamy, J., Shankar, B., Maheswari, U. K., Swaminathan, S., & Krishnakumar, S. (2013) · Europe PMC (PubMed Central) · Cited by 44 · see citing works

Down-regulation of TNF-α via macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis

Lee, J. E., Son, W., Hong, J., Song, Y., Yang, C., & Kim, Y. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.06.022 · Cited by 43 · see citing works

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide

Schiroli, D., Gomara, M. J., Maurizi, E., Atkinson, S. D., Mairs, L., Christie, K. A., Cobice, D., McCrudden, C. M., Nesbit, M. A., Haro, I., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.07.017 · Cited by 42 · see citing works

Application of Cell Penetrating Peptides as a Promising Drug Carrier to Combat Viral Infections

Khairkhah, N., Namvar, A., & Bolhassani, A. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00679-1 · Cited by 43 · see citing works

Crystallinity of Double-Stranded RNA-Antimicrobial Peptide Complexes Modulates Toll-Like Receptor 3-Mediated Inflammation

Lee, E. Y., Takahashi, T., Curk, T., Dobnikar, J., Gallo, R. L., & Wong, G. C. L. (2017) · ACS Nano · doi:10.1021/acsnano.7b05234 · Cited by 41 · see citing works

T.86. siRNA Delivery with Integrin LFA-1-targeted Nanoparticles Prevents HIV Infection in Humanized Mice

Kim, S. S., Peer, D., Kumar, P., Shimaoka, M., & Shankar, P. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.03.221 · Cited by 1 · see citing works

Cationic Cell-Penetrating Peptides as Vehicles for siRNA Delivery

Beloor, J., Zeller, S., Choi, C. S., Lee, S., & Kumar, P. (2015) · Therapeutic Delivery · doi:10.4155/tde.15.2 · Cited by 39 · see citing works

Tissue-Specific Cell Penetrating Peptides for Targeted Delivery of Small Interfering RNAs

Lopuszynski, J. B., Agrawal, V., & Zahid, M. (2022) · Medical Research Archives · doi:10.18103/mra.v10i8.2998 · Cited by 3 · see citing works

Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides

Meade, B. R., & Dowdy, S. F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.004 · Cited by 274 · see citing works

Intracellular Delivery of RNA via RNA-Binding Proteins or Peptides

Watanabe, K., & Ohtsuki, T. (2014) · Fundamental biomedical technologies · doi:10.1007/978-94-017-8896-0_19 · Cited by 2 · see citing works