The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers
Open accessAbstract
Oral delivery is the most common method for drug administration. However, poor solubility, stability, and bioavailability of many drugs make achieving therapeutic levels via the gastrointestinal (GI) tract challenging. Drug delivery must overcome numerous hurdles, including the acidic gastric environment and the continuous secretion of mucus that protects the GI tract. Nanoparticle drug carriers that can shield drugs from degradation and deliver them to intended sites within the GI tract may enable more efficient and sustained drug delivery. However, the rapid secretion and shedding of GI tract mucus can significantly limit the effectiveness of nanoparticle drug delivery systems. Many types of nanoparticles are efficiently trapped in and rapidly removed by mucus, making controlled release in the GI tract difficult. This review addresses the protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier.
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Cites
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Self-citationBiologically erodable microspheres as potential oral drug delivery systems
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Cited by
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Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0090-8 · Cited by 7,933
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Self-citationEnvironmental exposure to microplastics: An overview on possible human health effects
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Nanoemulsion: Concepts, development and applications in drug delivery
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Metadata
- Authors
- Ensign, L. M., Cone, R., & Hanes, J.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 64
- Issue
- 6
- Pages
- 557-570
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2055037481
- Cited by
- 1,623
- References
- 11
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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