The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances
Open accessAbstract
Targeting of drugs and their carrier systems by using receptor-mediated endocytotic pathways was in its nascent stages 25 years ago. In the intervening years, an explosion of knowledge focused on design and synthesis of nanoparticulate delivery systems as well as elucidation of the cellular complexity of what was previously-termed receptor-mediated endocytosis has now created a situation when it has become possible to design and test the feasibility of delivery of highly specific nanoparticle drug carriers to specific cells and tissue. This review outlines the mechanisms governing the major modes of receptor-mediated endocytosis used in drug delivery and highlights recent approaches using these as targets for in vivo drug delivery of nanoparticles. The review also discusses some of the inherent complexity associated with the simple shift from a ligand-drug conjugate versus a ligand-nanoparticle conjugate, in terms of ligand valency and its relationship to the mode of receptor-mediated internalization.
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Metadata
- Authors
- Xu, S., Olenyuk, B. Z., Okamoto, C. T., & Hamm-Alvarez, S. F.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 65
- Issue
- 1
- Pages
- 121-138
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2066467291
- Cited by
- 467
- References
- 19
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Xu, S., Olenyuk, B. Z., Okamoto, C. T., & Hamm-Alvarez, S. F. (2013). Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2012.09.041
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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