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Role of integrated cancer nanomedicine in overcoming drug resistance
Abstract
Cancer remains a major killer of mankind. Failure of conventional chemotherapy has resulted in recurrence and development of virulent multi drug resistant (MDR) phenotypes adding to the complexity and diversity of this deadly disease. Apart from displaying classical physiological abnormalities and aberrant blood flow behavior, MDR cancers exhibit several distinctive features such as higher apoptotic threshold, aerobic glycolysis, regions of hypoxia, and elevated activity of drug-efflux transporters. MDR transporters play a pivotal role in protecting the cancer stem cells (CSCs) from chemotherapy. It is speculated that CSCs are instrumental in reviving tumors after the chemo and radiotherapy. In this regard, multifunctional nanoparticles that can integrate various key components such as drugs, genes, imaging agents and targeting ligands using unique delivery platforms would be more efficient in treating MDR cancers. This review presents some of the important principles involved in development of MDR and novel methods of treating cancers using multifunctional-targeted nanoparticles. Illustrative examples of nanoparticles engineered for drug/gene combination delivery and stimuli responsive nanoparticle systems for cancer therapy are also discussed.
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“Due to the enhanced permeability and retention effect (EPR effect), 174 selective accumulation in solid tumors can be used to target hypoxic tumors more effectively.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [175]
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Metadata
- Authors
- Iyer, A. K., Singh, A., Ganta, S., & Amiji, M. M.
- Affiliations
- Northeastern University (US)
- Nemucore Medical Innovations (United States) (US)
- Corresponding author
- Amiji, Mansoor M.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 65
- Issue
- 13-14
- Pages
- 1784-1802
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2000798536
- Cited by
- 343
- References
- 242
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 31 · 2023: 26 · 2022: 28 · 2021: 32 · 2020: 26 · 2019: 33 · 2018: 30 · 2017: 31 · 2016: 33 · 2015: 23 · 2014: 27 · 2013: 1
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Update notices
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- cancer nanomedicine, multidrug resistance, drug resistance, multifunctional nanoparticles, targeted drug delivery, cancer stem cells, efflux pumps, stimuli-responsive nanoparticles, tumor hypoxia, aerobic glycolysis, tumor recurrence
- MeSH terms
- Animals, Antineoplastic Agents, Drug Carriers, Humans, Neoplasms, Drug Delivery Systems, Drug Resistance, Neoplasm, Nanomedicine, Nanoparticles, Molecular Targeted Therapy
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